Associations of essential element serum concentrations with autism spectrum disorder.
Autism spectrum disorder
Children
Essential elements
Serum
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
17
01
2022
accepted:
08
07
2022
pubmed:
17
7
2022
medline:
23
11
2022
entrez:
16
7
2022
Statut:
ppublish
Résumé
This case-control study explored the associations between autism spectrum disorder (ASD) and the serum concentration of nine chemical elements in children. The study recruited 92 Chinese children with ASD and 103 typically developing individuals. Serum concentrations of nine chemical elements (calcium, iodine, iron, lithium, magnesium, potassium, selenium, strontium, and zinc) were determined by inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma atomic emission spectrometry (ICP-AES). An unconditional logistic regression model was used to analyze the associations between the serum concentrations of the elements and the risk of ASD. After adjusting for confounders, the multivariate analysis results showed that zinc ≤ 837.70 ng/mL, potassium > 170.06 μg/mL, and strontium ≤ 52.46 ng/mL were associated with an increased risk of ASD, while selenium > 159.80 ng/mL was associated with a decreased risk of ASD. Furthermore, the degree of lithium and zinc deficiency was associated with ASD severity. The results indicated that metallomic profiles of some specific elements might play important roles in the development of ASD, a finding of scientific significance for understanding the etiology, and providing dietary guidance for certain ASD types.
Identifiants
pubmed: 35842508
doi: 10.1007/s11356-022-21978-1
pii: 10.1007/s11356-022-21978-1
doi:
Substances chimiques
Trace Elements
0
Selenium
H6241UJ22B
Lithium
9FN79X2M3F
Zinc
J41CSQ7QDS
Potassium
RWP5GA015D
Strontium
YZS2RPE8LE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
88962-88971Subventions
Organisme : Beijing Municipal Science & Technology Commission
ID : Z181100001518005
Organisme : National Basic Research Program of China
ID : 2017YFA0105201
Organisme : Key Realm R&D Program of GuangDong Province
ID : 2019B030335001
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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