Prevotella: An insight into its characteristics and associated virulence factors.
Hemolysins
Lipopolysaccharide
Periodontitis
Prevotella spp.
Proteases
Secretion Systems
Virulence Factor
Journal
Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
11
01
2022
revised:
04
06
2022
accepted:
06
07
2022
pubmed:
18
7
2022
medline:
10
8
2022
entrez:
17
7
2022
Statut:
ppublish
Résumé
Prevotella species, a gram-negative obligate anaerobe, is commonly associated with human infections such as dental caries and periodontitis, as well as other conditions such as chronic osteomyelitis, bite-related infections, rheumatoid arthritis and intestinal diseases like ulcerative colitis. This generally harmless commensal possesses virulence factors such as adhesins, hemolysins, secretion systems exopolysaccharide, LPS, proteases, quorum sensing molecules and antibiotic resistance to evolve into a well-adapted pathogen capable of causing successful infection and proliferation in the host tissue. This review describes several of these virulence factors and their advantage to Prevotella spp. in causing inflammatory diseases like periodontitis. In addition, using genome analysis of Prevotella reference strains, we examined other putative virulence determinants which can provide insights as biomarkers and be the targets for effective interventions in Prevotella related diseases like periodontitis.
Identifiants
pubmed: 35843443
pii: S0882-4010(22)00286-8
doi: 10.1016/j.micpath.2022.105673
pii:
doi:
Substances chimiques
Virulence Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105673Informations de copyright
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