Inhibition of
Arenaviridae
Lassa virus
Lymphocytic choriomeningitis virus
Mopeia virus
alendronate
compound optimization
exonucleases
metal chelation
Journal
IUCrJ
ISSN: 2052-2525
Titre abrégé: IUCrJ
Pays: England
ID NLM: 101623101
Informations de publication
Date de publication:
01 Jul 2022
01 Jul 2022
Historique:
received:
07
03
2022
accepted:
11
05
2022
entrez:
18
7
2022
pubmed:
19
7
2022
medline:
19
7
2022
Statut:
epublish
Résumé
Arenaviruses are emerging enveloped negative-sense RNA viruses that cause neurological and hemorrhagic diseases in humans. Currently, no FDA-approved vaccine or therapeutic agent is available except for ribavirin, which must be administered early during infection for optimum efficacy. A hallmark of arenavirus infection is rapid and efficient immune suppression mediated by the exonuclease domain encoded by the nucleoprotein. This exonuclease is therefore an attractive target for the design of novel antiviral drugs since exonuclease inhibitors might not only have a direct effect on the enzyme but could also boost viral clearance through stimulation of the innate immune system of the host cell. Here,
Identifiants
pubmed: 35844481
doi: 10.1107/S2052252522005061
pii: S2052252522005061
pmc: PMC9252148
doi:
Types de publication
Journal Article
Langues
eng
Pagination
468-479Informations de copyright
© Thi Hong Van Nguyen et al. 2022.
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