ABO subgroup incompatibility with severe hemolysis after consecutive allogeneic stem cell transplantations.
A1/A2 subtyping of blood group A
ABO incompatibility
allogeneic hematopoietic stem cell transplantation
hemolysis
Journal
EJHaem
ISSN: 2688-6146
Titre abrégé: EJHaem
Pays: United States
ID NLM: 101761942
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
06
01
2021
revised:
10
03
2021
accepted:
12
03
2021
entrez:
18
7
2022
pubmed:
24
3
2021
medline:
24
3
2021
Statut:
epublish
Résumé
Allogeneic hematopoietic stem cell transplantations (HSCTs) represent a curative strategy for treating hematologic malignancies yet bear dangerous and frequently life-threatening complications including the development of graft-versus-host disease. Here, we present a case of a patient that suffered from relapsed/refractory multiple myeloma, a hematologic neoplasm characterized by clonal proliferation of malignant plasma cells in the bone marrow. During the course of his disease, the patient underwent consecutive allogeneic HSCTs, during which he developed a clinical meaningful and hitherto unreported ABO subgroup incompatibility, leading to persistent hemolysis. Testing for ABO subgroups during donor selection, especially after consecutive allogeneic HSCTs, may therefore aid to prevent these complications.
Identifiants
pubmed: 35845280
doi: 10.1002/jha2.190
pii: JHA2190
pmc: PMC9175969
doi:
Types de publication
Case Reports
Langues
eng
Pagination
280-284Informations de copyright
© 2021 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.
Déclaration de conflit d'intérêts
The authors declare no competing financial interests.
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