Haematological malignancies in relatives of patients affected with myeloproliferative neoplasms.
familial
malignancies
myeloproliferative
relatives
Journal
EJHaem
ISSN: 2688-6146
Titre abrégé: EJHaem
Pays: United States
ID NLM: 101761942
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
11
03
2022
revised:
11
03
2022
accepted:
11
03
2022
entrez:
18
7
2022
pubmed:
19
7
2022
medline:
19
7
2022
Statut:
epublish
Résumé
In a cohort of 3131 patients with myeloproliferative neoplasms (MPNs), we identified 200 patients (6.4%) who reported a second case of haematological malignancies (HM) in first- or second-degree relatives. The occurrence of a second HM in the family was not influenced by MPN subtype, sex or driver mutation, while it was associated with age at MPN diagnosis: 8.5% of patients diagnosed with MPN younger than 45 years had a second relative affected with HM compared to 5.5% of those diagnosed at the age of 45 years or older (
Identifiants
pubmed: 35846061
doi: 10.1002/jha2.425
pii: JHA2425
pmc: PMC9176120
doi:
Types de publication
Journal Article
Langues
eng
Pagination
475-479Informations de copyright
© 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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