Adult T cell leukaemia/lymphoma (ATL) in pregnancy: A UK case series.

ATL HTLV‐1 antiretrovirals pregnancy screening

Journal

EJHaem
ISSN: 2688-6146
Titre abrégé: EJHaem
Pays: United States
ID NLM: 101761942

Informations de publication

Date de publication:
Feb 2021
Historique:
received: 29 09 2020
revised: 12 11 2020
accepted: 12 11 2020
entrez: 18 7 2022
pubmed: 25 11 2020
medline: 25 11 2020
Statut: epublish

Résumé

Chronic infection with human T-cell lymphotropic virus type-1 (HTLV-1) may result in aggressive adult T-cell leukaemia/lymphoma (ATL) in 4-6% carriers. The majority of this risk arises in carriers infected during infancy, and so each infant has ∼25% lifetime risk. Other risk factors include a family history of ATL. Antenatal HTLV-1 screening is not undertaken in the UK. Here we describe four cases of ATL diagnosed during pregnancy and describe strategies to minimise HTLV-1 transmission to neonates. These cases highlight undiagnosed HTLV-1 in pregnancy which allows ongoing mother to child vertical transmission and risk of future ATL. We recommend the UK National Screening Committee incorporate HTLV-1 serology into antenatal screening.

Identifiants

pubmed: 35846087
doi: 10.1002/jha2.142
pii: JHA2142
pmc: PMC9175930
doi:

Types de publication

Journal Article

Langues

eng

Pagination

131-135

Informations de copyright

© 2020 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.

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Auteurs

Leila Motedayen Aval (L)

Section of Virology, Imperial College London UK.

Mary Boullier (M)

Department of Paediatrics St George's University Hospitals NHS Foundation Trust London UK.

Hermione Lyall (H)

Department of Paediatric Infectious Diseases Imperial College Healthcare NHS Trust London UK.

Graham P Collins (GP)

Department of Haematology Oxford University Hospitals NHS Foundation Trust Oxford UK.

Robert Ayto (R)

Department of Haematology Portsmouth Hospitals NHS Trust Hampshire UK.

Dominic F Kelly (DF)

Oxford Vaccine Group Department of Paediatrics University of Oxford Oxford UK.
NIHR Oxford Biomedical Research Centre Oxford UK.

Richard S Tedder (RS)

Section of Virology, Imperial College London UK.

Simon B Drysdale (SB)

Department of Paediatrics St George's University Hospitals NHS Foundation Trust London UK.
Oxford Vaccine Group Department of Paediatrics University of Oxford Oxford UK.

Graham P Taylor (GP)

Section of Virology, Imperial College London UK.
National Centre for Human Retrovirology Imperial College Healthcare NHS Trust London UK.

Lucy B Cook (LB)

Section of Virology, Imperial College London UK.
Centre for Haematology Imperial College Healthcare NHS Trust London UK.
National Centre for Human Retrovirology Imperial College Healthcare NHS Trust London UK.

Classifications MeSH