Adult T cell leukaemia/lymphoma (ATL) in pregnancy: A UK case series.
ATL
HTLV‐1
antiretrovirals
pregnancy
screening
Journal
EJHaem
ISSN: 2688-6146
Titre abrégé: EJHaem
Pays: United States
ID NLM: 101761942
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
29
09
2020
revised:
12
11
2020
accepted:
12
11
2020
entrez:
18
7
2022
pubmed:
25
11
2020
medline:
25
11
2020
Statut:
epublish
Résumé
Chronic infection with human T-cell lymphotropic virus type-1 (HTLV-1) may result in aggressive adult T-cell leukaemia/lymphoma (ATL) in 4-6% carriers. The majority of this risk arises in carriers infected during infancy, and so each infant has ∼25% lifetime risk. Other risk factors include a family history of ATL. Antenatal HTLV-1 screening is not undertaken in the UK. Here we describe four cases of ATL diagnosed during pregnancy and describe strategies to minimise HTLV-1 transmission to neonates. These cases highlight undiagnosed HTLV-1 in pregnancy which allows ongoing mother to child vertical transmission and risk of future ATL. We recommend the UK National Screening Committee incorporate HTLV-1 serology into antenatal screening.
Identifiants
pubmed: 35846087
doi: 10.1002/jha2.142
pii: JHA2142
pmc: PMC9175930
doi:
Types de publication
Journal Article
Langues
eng
Pagination
131-135Informations de copyright
© 2020 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.
Références
BMJ. 2017 Sep 11;358:j3961
pubmed: 28893728
Br J Haematol. 2019 Mar;184(6):1040-1043
pubmed: 29676441
J Obstet Gynaecol Res. 1996 Dec;22(6):599-601
pubmed: 9037951
Obstet Gynecol. 1988 Sep;72(3 Pt 2):445-7
pubmed: 2900485
N Engl J Med. 2002 Jun 20;346(25):2014-5
pubmed: 12075070
Proc Jpn Acad Ser B Phys Biol Sci. 2011;87(4):152-66
pubmed: 21558754
J Acquir Immune Defic Syndr Hum Retrovirol. 1996;13 Suppl 1:S20-5
pubmed: 8797699
Case Rep Oncol Med. 2013;2013:631825
pubmed: 23840994
Front Microbiol. 2020 May 29;11:1124
pubmed: 32547527
Antimicrob Agents Chemother. 2011 May;55(5):2011-7
pubmed: 21343468
J Clin Oncol. 2019 Mar 10;37(8):677-687
pubmed: 30657736
J Clin Oncol. 2009 Jan 20;27(3):453-9
pubmed: 19064971
Lancet Infect Dis. 2020 Jan;20(1):133-143
pubmed: 31648940
PLoS Negl Trop Dis. 2019 Sep 12;13(9):e0007736
pubmed: 31513603
F1000Res. 2019 Feb 28;8:
pubmed: 30854194
Int J Cancer. 1999 Oct 29;83(3):291-8
pubmed: 10495418
Blood. 2010 Aug 26;116(8):1211-9
pubmed: 20448111
J Obstet Gynaecol Res. 2016 Mar;42(3):336-40
pubmed: 26663442
Blood Adv. 2020 May 12;4(9):2044-2048
pubmed: 32396612
Br J Haematol. 2020 Feb;188(4):e46-e49
pubmed: 31743423