"Ideal" parathyroid hormone in erythropoietin-stimulating agents-resistant anemia.
ESA‐resistant anemia
ESRD
PTH
bone marrow fibrosis
secondary hyperparathyroidism
Journal
EJHaem
ISSN: 2688-6146
Titre abrégé: EJHaem
Pays: United States
ID NLM: 101761942
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
12
09
2021
revised:
24
09
2021
accepted:
27
09
2021
entrez:
18
7
2022
pubmed:
19
7
2022
medline:
19
7
2022
Statut:
epublish
Résumé
Erythropoietin-stimulating agents (ESAs) have revolutionized anemia treatment in end-stage renal disease (ESRD), but ESA resistance is increasingly identified. Secondary hyperparathyroidism (SHP) is one cause of ESA resistance. We describe a patient with ESA-resistant, transfusion-dependent anemia and mild SHP with remodeling and reticulin fibrosis on bone marrow biopsy, all of which resolved with stricter SHP management. We identified 64 patients with anemia, ESRD, and bone marrow biopsy. The parathyroid hormone (PTH) range for bony remodeling was 183-16,161.9 pg/ml versus 90.8-3283 pg/ml. The PTH range for fibrotic changes was 183-2487 pg/ml versus 90.8-16,161.9 pg/ml. We found no clear PTH range predictive for bone marrow changes.
Identifiants
pubmed: 35846199
doi: 10.1002/jha2.316
pii: JHA2316
pmc: PMC9176131
doi:
Types de publication
Journal Article
Langues
eng
Pagination
159-162Informations de copyright
© 2021 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.
Déclaration de conflit d'intérêts
All authors had no conflicts of interest to declare.
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