Tryptophan Metabolites as Mediators of Microbiota-Gut-Brain Communication: Focus on Isatin.
brain
gut-brain axis
interactome
isatin
isatin-binding proteins
molecular targets
protein-protein interactions
tryptophan metabolites
Journal
Frontiers in behavioral neuroscience
ISSN: 1662-5153
Titre abrégé: Front Behav Neurosci
Pays: Switzerland
ID NLM: 101477952
Informations de publication
Date de publication:
2022
2022
Historique:
received:
17
04
2022
accepted:
31
05
2022
entrez:
18
7
2022
pubmed:
19
7
2022
medline:
19
7
2022
Statut:
epublish
Résumé
Isatin (indole-2,3-dione) is an endogenous regulator, exhibiting various behavioral, biological, and pharmacological activities. Synthesis of isatin includes several crucial stages: cleavage of the tryptophan side chain and subsequent oxidation of the indole nucleus. Although these stages require concerted action of bacterial and host enzymes, there are two pathways of isatin formation: the host and bacterial pathways. Isatin acts as a neuroprotector in different experimental models of neurodegeneration. Its effects are realized
Identifiants
pubmed: 35846785
doi: 10.3389/fnbeh.2022.922274
pmc: PMC9280024
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
922274Informations de copyright
Copyright © 2022 Medvedev and Buneeva.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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