Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction: Pathophysiology, Assessment, Prevalence and Prognosis.
Heart failure with preserved ejection fraction
cardiovascular MRI
diagnosis
fibrosis
microvascular dysfunction
prevalence
prognosis
Journal
Cardiac failure review
ISSN: 2057-7540
Titre abrégé: Card Fail Rev
Pays: England
ID NLM: 101696210
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
26
02
2022
accepted:
03
04
2022
entrez:
18
7
2022
pubmed:
19
7
2022
medline:
19
7
2022
Statut:
epublish
Résumé
Heart failure with preserved ejection fraction (HFpEF) currently accounts for approximately half of all new heart failure cases in the community. HFpEF is closely associated with chronic lifestyle-related diseases, such as obesity and type 2 diabetes, and clinical outcomes are worse in those with than without comorbidities. HFpEF is pathophysiologically distinct from heart failure with reduced ejection fraction, which may explain, in part, the disparity of treatment options available between the two heart failure phenotypes. The mechanisms underlying HFpEF are complex, with coronary microvascular dysfunction (MVD) being proposed as a potential key driver in its pathophysiology. In this review, the authors highlight the evidence implicating MVD in HFpEF pathophysiology, the diagnostic approaches for identifying MVD (both invasive and non-invasive) and the prevalence and prognostic significance of MVD.
Identifiants
pubmed: 35846985
doi: 10.15420/cfr.2022.12
pmc: PMC9274364
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e24Subventions
Organisme : Academy of Medical Sciences
ID : AMS-SGCL12-MILLER
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/17/47/32805
Pays : United Kingdom
Informations de copyright
Copyright © 2022, Radcliffe Cardiology.
Déclaration de conflit d'intérêts
Disclosure: CAM has served on advisory boards for Novartis, Boehringer Ingelheim and Lilly Alliance, and AstraZeneca, serves as an advisor for HAYA Therapeutics and PureTech Health and has received research support from Amicus Therapeutics, Guerbet Laboratories Limited, Roche and Univar Solutions. PK has received honoraria for presentations from Novartis and NovoNordisk, and is on the Cardiac Failure Review editorial board; this did not influence peer review. All other authors have no conflicts of interest to declare.
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