CRISPR/Cas9
cccDNA
delivery
gene therapy
hepatitis B virus
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2022
2022
Historique:
received:
25
05
2022
accepted:
15
06
2022
entrez:
18
7
2022
pubmed:
19
7
2022
medline:
19
7
2022
Statut:
epublish
Résumé
Chronic hepatitis B virus (HBV) infection remains a major global health problem despite the availability of an effective prophylactic HBV vaccine. Current antiviral therapies are unable to fully cure chronic hepatitis B (CHB) because of the persistent nature of covalently closed circular DNA (cccDNA), a replicative template for HBV, which necessitates the development of alternative therapeutic approaches. The CRISPR/Cas system, a newly emerging genome editing tool, holds great promise for genome editing and gene therapy. Several
Identifiants
pubmed: 35847068
doi: 10.3389/fmicb.2022.953218
pmc: PMC9284033
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
953218Informations de copyright
Copyright © 2022 Kayesh, Hashem, Kohara and Tsukiyama-Kohara.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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