Outer Membrane Vesicles From The Gut Microbiome Contribute to Tumor Immunity by Eliciting Cross-Reactive T Cells.
cancer
cancer vaccines
microbiome
molecular mimicry
outer membrane vesicles
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
04
04
2022
accepted:
20
05
2022
entrez:
18
7
2022
pubmed:
19
7
2022
medline:
19
7
2022
Statut:
epublish
Résumé
A growing body of evidence supports the notion that the gut microbiome plays an important role in cancer immunity. However, the underpinning mechanisms remain to be fully elucidated. One attractive hypothesis envisages that among the T cells elicited by the plethora of microbiome proteins a few exist that incidentally recognize neo-epitopes arising from cancer mutations ("molecular mimicry (MM)" hypothesis). To support MM, the human probiotic
Identifiants
pubmed: 35847919
doi: 10.3389/fonc.2022.912639
pmc: PMC9281500
doi:
Types de publication
Journal Article
Langues
eng
Pagination
912639Informations de copyright
Copyright © 2022 Tomasi, Caproni, Benedet, Zanella, Giorgetta, Dalsass, König, Gagliardi, Fantappiè, Berti, Tamburini, Croia, Di Lascio, Bellini, Valensin, Licata, Sebastiani, Dotta, Armanini, Cumbo, Asnicar, Blanco-Míguez, Ruggiero, Segata, Grandi and Grandi.
Déclaration de conflit d'intérêts
GG, AGr, LF, AG, EK, IZ, and MT are co-inventors of one or more patents on OMVs; AGr and GG are involved in BiOMViS Srl interested in exploiting the OMV platform. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor MB declared a shared affiliation with the author ER at the time of review.
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