Humoral Response and SARS-CoV-2 Infection Risk following the Third and Fourth Doses of the BNT162b2 Vaccine in Dialysis Patients.
COVID-19
Hemodialysis
Humoral response
Vaccination
Journal
American journal of nephrology
ISSN: 1421-9670
Titre abrégé: Am J Nephrol
Pays: Switzerland
ID NLM: 8109361
Informations de publication
Date de publication:
2022
2022
Historique:
received:
18
04
2022
accepted:
12
05
2022
pubmed:
20
7
2022
medline:
20
8
2022
entrez:
19
7
2022
Statut:
ppublish
Résumé
The optimal SARS-CoV-2 vaccination schedule in dialysis patients and the potential need for a fourth vaccine dose are debatable. We prospectively assessed the humoral responses to three and four doses of BNT162b2 among dialysis patients. The study included 106 dialysis patients; 60 (56.6%) and 46 (43.4%) received 3 and 4 vaccine doses, respectively. Anti-spike (anti-S) antibody titers significantly increased after the third vaccine dose, followed by a decline, yet still remained higher than all previous measurements. The fourth vaccine dose led to another profound rise in anti-S titers. The absolute increase following the fourth dose correlated with response to the third dose. Infection risk however was similar between patients vaccinated with three or four doses.
Identifiants
pubmed: 35850101
pii: 000525309
doi: 10.1159/000525309
pmc: PMC9501772
doi:
Substances chimiques
Antibodies, Viral
0
COVID-19 Vaccines
0
Viral Vaccines
0
BNT162 Vaccine
N38TVC63NU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
586-590Informations de copyright
© 2022 The Author(s). Published by S. Karger AG, Basel.
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