Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
18 07 2022
18 07 2022
Historique:
received:
12
12
2021
accepted:
08
07
2022
entrez:
19
7
2022
pubmed:
20
7
2022
medline:
22
7
2022
Statut:
epublish
Résumé
T-follicular helper (Tfh) cells are key drivers of antibodies that protect from malaria. However, little is known regarding the host and parasite factors that influence Tfh and functional antibody development. Here, we use samples from a large cross-sectional study of children residing in an area of high malaria transmission in Uganda to characterize Tfh cells and functional antibodies to multiple parasites stages. We identify a dramatic re-distribution of the Tfh cell compartment with age that is independent of malaria exposure, with Th2-Tfh cells predominating in early childhood, while Th1-Tfh cell gradually increase to adult levels over the first decade of life. Functional antibody acquisition is age-dependent and hierarchical acquired based on parasite stage, with merozoite responses followed by sporozoite and gametocyte antibodies. Antibodies are boosted in children with current infection, and are higher in females. The children with the very highest antibody levels have increased Tfh cell activation and proliferation, consistent with a key role of Tfh cells in antibody development. Together, these data reveal a complex relationship between the circulating Tfh compartment, antibody development and protection from malaria.
Identifiants
pubmed: 35851033
doi: 10.1038/s41467-022-31880-6
pii: 10.1038/s41467-022-31880-6
pmc: PMC9293980
doi:
Substances chimiques
Antibodies, Protozoan
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4159Subventions
Organisme : NIAID NIH HHS
ID : K24 AI144048
Pays : United States
Organisme : NIAID NIH HHS
ID : K23 AI076614
Pays : United States
Organisme : NIAID NIH HHS
ID : K24 AI113002
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI089674
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI150741
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI093615
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
BMC Med. 2019 Feb 25;17(1):45
pubmed: 30798787
J Infect Dis. 2016 Oct 1;214(7):1072-80
pubmed: 27481862
Infect Immun. 1997 Aug;65(8):3017-23
pubmed: 9234748
J Immunol. 2016 Aug 1;197(3):983-93
pubmed: 27342848
Nat Rev Immunol. 2016 Oct;16(10):626-38
pubmed: 27546235
J Immunol. 2016 Aug 15;197(4):1507-16
pubmed: 27385782
PLoS Pathog. 2015 Mar 12;11(3):e1004715
pubmed: 25763578
Cell Rep. 2015 Oct 13;13(2):425-39
pubmed: 26440897
Cell Rep. 2016 Jan 5;14(1):68-81
pubmed: 26725120
J Exp Med. 2021 Apr 5;218(4):
pubmed: 33661303
Front Immunol. 2018 Jul 25;9:1660
pubmed: 30090099
Infect Immun. 2005 Dec;73(12):8119-29
pubmed: 16299306
Nat Commun. 2021 Mar 19;12(1):1742
pubmed: 33741975
Immunity. 2011 Jan 28;34(1):108-21
pubmed: 21215658
PLoS One. 2020 Dec 17;15(12):e0243943
pubmed: 33332459
PLoS Pathog. 2017 Sep 27;13(9):e1006576
pubmed: 28953967
EBioMedicine. 2017 Oct;24:216-230
pubmed: 28888925
J Infect Dis. 2013 Aug 15;208(4):645-52
pubmed: 23633405
Clin Infect Dis. 2013 Jul;57(1):40-7
pubmed: 23487390
Elife. 2020 Oct 27;9:
pubmed: 33107430
Sci Rep. 2017 Sep 13;7(1):11487
pubmed: 28904345
J Stat Softw. 2010;33(1):1-22
pubmed: 20808728
Infect Immun. 2001 Feb;69(2):1207-11
pubmed: 11160024
PLoS One. 2019 Sep 10;14(9):e0221733
pubmed: 31504038
Parasite Immunol. 2010 Feb;32(2):125-34
pubmed: 20070826
Sci Immunol. 2017 Feb;2(8):
pubmed: 28620653
Am J Trop Med Hyg. 1998 Apr;58(4):406-13
pubmed: 9574783
Eur J Immunol. 2006 Jul;36(7):1892-903
pubmed: 16791882
Immunity. 2012 Nov 16;37(5):771-83
pubmed: 23159225
Front Immunol. 2019 Mar 15;10:439
pubmed: 30930896
Mol Cell Proteomics. 2006 Jul;5(7):1286-99
pubmed: 16603573
Front Immunol. 2017 Oct 19;8:1329
pubmed: 29097996
Immunity. 2013 Oct 17;39(4):758-69
pubmed: 24035365
Sci Adv. 2019 Sep 25;5(9):eaax4489
pubmed: 31579826
PLoS One. 2013 Sep 09;8(9):e74627
pubmed: 24040299
Elife. 2018 Jul 25;7:
pubmed: 30044224
Immunity. 2015 Mar 17;42(3):580-90
pubmed: 25786180
J Immunol. 2005 Aug 15;175(4):2340-8
pubmed: 16081804
EBioMedicine. 2022 Jan;75:103784
pubmed: 34968760
JCI Insight. 2021 Jul 22;6(14):
pubmed: 34128836
Lancet Infect Dis. 2021 Nov;21(11):1568-1578
pubmed: 34146476
Med (N Y). 2021 Jun 11;2(6):701-719.e19
pubmed: 34223402
J Clin Invest. 2019 Jul 2;129(8):3185-3200
pubmed: 31264971
Infect Immun. 2015 Feb;83(2):646-60
pubmed: 25422270
Infect Immun. 2009 Mar;77(3):1165-74
pubmed: 19139189
Immunol Rev. 2020 Jan;293(1):38-56
pubmed: 31556468
BMC Med. 2014 Jul 01;12:108
pubmed: 24980799
Acta Trop. 2015 Feb;142:47-56
pubmed: 25446174
Parasite Immunol. 1994 Oct;16(10):511-9
pubmed: 7532850
Cell Rep Med. 2020 Dec 22;1(9):100157
pubmed: 33377128
PLoS One. 2015 Dec 08;10(12):e0144654
pubmed: 26646149
BMC Med. 2018 Apr 30;16(1):61
pubmed: 29706136
Clin Infect Dis. 2010 Oct 15;51(8):e50-60
pubmed: 20843207
Curr Opin Physiol. 2018 Dec;6:16-20
pubmed: 30320243
Malar J. 2008 Jul 29;7:142
pubmed: 18664257
Sci Transl Med. 2019 Jan 9;11(474):
pubmed: 30626712
iScience. 2020 Jul 24;23(7):101310
pubmed: 32634740
Nat Commun. 2019 Feb 5;10(1):610
pubmed: 30723225
Infect Immun. 2016 Jul 21;84(8):2175-2184
pubmed: 27185785
Am J Trop Med Hyg. 2015 May;92(5):903-12
pubmed: 25778501
Nature. 1961 Nov 25;192:733-7
pubmed: 13880318
J Infect Dis. 2018 Jun 5;218(1):35-43
pubmed: 29584918
J Infect Dis. 2021 Oct 13;224(7):1128-1138
pubmed: 32236404
Immunity. 2019 May 21;50(5):1132-1148
pubmed: 31117010
J Infect Dis. 2011 Jul 1;204(1):19-26
pubmed: 21628654
Malar J. 2014 Mar 21;13:111
pubmed: 24656206
Infect Immun. 2006 Jan;74(1):257-64
pubmed: 16368979
Immunity. 2018 Dec 18;49(6):1034-1048.e8
pubmed: 30566881
Mol Biochem Parasitol. 1995 Dec;75(1):33-42
pubmed: 8720173
Nat Immunol. 2019 Oct;20(10):1360-1371
pubmed: 31477921