Bone remodeling: an operational process ensuring survival and bone mechanical competence.
Journal
Bone research
ISSN: 2095-4700
Titre abrégé: Bone Res
Pays: China
ID NLM: 101608652
Informations de publication
Date de publication:
18 Jul 2022
18 Jul 2022
Historique:
received:
02
08
2021
accepted:
15
05
2022
revised:
02
05
2022
entrez:
19
7
2022
pubmed:
20
7
2022
medline:
20
7
2022
Statut:
epublish
Résumé
Bone remodeling replaces old and damaged bone with new bone through a sequence of cellular events occurring on the same surface without any change in bone shape. It was initially thought that the basic multicellular unit (BMU) responsible for bone remodeling consists of osteoclasts and osteoblasts functioning through a hierarchical sequence of events organized into distinct stages. However, recent discoveries have indicated that all bone cells participate in BMU formation by interacting both simultaneously and at different differentiation stages with their progenitors, other cells, and bone matrix constituents. Therefore, bone remodeling is currently considered a physiological outcome of continuous cellular operational processes optimized to confer a survival advantage. Bone remodeling defines the primary activities that BMUs need to perform to renew successfully bone structural units. Hence, this review summarizes the current understanding of bone remodeling and future research directions with the aim of providing a clinically relevant biological background with which to identify targets for therapeutic strategies in osteoporosis.
Identifiants
pubmed: 35851054
doi: 10.1038/s41413-022-00219-8
pii: 10.1038/s41413-022-00219-8
pmc: PMC9293977
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
48Informations de copyright
© 2022. The Author(s).
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