Selective activation of Gαob by an adenosine A
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
18 07 2022
18 07 2022
Historique:
received:
21
07
2020
accepted:
23
06
2022
entrez:
19
7
2022
pubmed:
20
7
2022
medline:
22
7
2022
Statut:
epublish
Résumé
The development of therapeutic agonists for G protein-coupled receptors (GPCRs) is hampered by the propensity of GPCRs to couple to multiple intracellular signalling pathways. This promiscuous coupling leads to numerous downstream cellular effects, some of which are therapeutically undesirable. This is especially the case for adenosine A
Identifiants
pubmed: 35851064
doi: 10.1038/s41467-022-31652-2
pii: 10.1038/s41467-022-31652-2
pmc: PMC9293909
doi:
Substances chimiques
Receptors, G-Protein-Coupled
0
Receptors, Purinergic P1
0
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4150Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M00015X/2
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M01116X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J003964/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : 2270402
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_15070
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
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