ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16

Adenosine Deaminase / genetics Animals Autophagy / genetics Cellular Senescence / genetics Cyclin-Dependent Kinase Inhibitor p16 / genetics Down-Regulation Female Humans Mice RNA Editing / genetics RNA Processing, Post-Transcriptional / genetics RNA, Messenger / metabolism Sirtuin 1 / genetics

Journal

Nature cell biology
ISSN: 1476-4679
Titre abrégé: Nat Cell Biol
Pays: England
ID NLM: 100890575

Informations de publication

Date de publication:
08 2022
Historique:
received: 08 07 2021
accepted: 07 06 2022
pubmed: 20 7 2022
medline: 11 8 2022
entrez: 19 7 2022
Statut: ppublish

Résumé

Cellular senescence plays a causal role in ageing and, in mice, depletion of p16

Identifiants

DOI: 10.1038/s41556-022-00959-z PMID: 35851616 PMC: PMC9757154
pubmed: 35851616
doi: 10.1038/s41556-022-00959-z
pii: 10.1038/s41556-022-00959-z
pmc: PMC9757154
mid: NIHMS1854038
doi:

Substances chimiques

Cdkn2a protein, mouse 0
Cyclin-Dependent Kinase Inhibitor p16 0
RNA, Messenger 0
Sirtuin 1 EC 3.5.1.-
ADAR1 protein, mouse EC 3.5.4.4
Adenosine Deaminase EC 3.5.4.4

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1202-1210

Subventions

Organisme : NIH HHS
ID : S10 OD030245
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM040536
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM130716
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA010815
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM129069
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG031862
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211199
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA243142
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA160331
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA030199
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM084089
Pays : United States

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

Références

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Auteurs

Xue Hao (X)

Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
ORCID: 0000-0003-4138-1447

Yusuke Shiromoto (Y)

Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Department of Molecular Genetics, Graduate School of Medicine Kyoto University, Kyoto, Japan.
ORCID: 0000-0001-5984-1726

Masayuki Sakurai (M)

Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan.
ORCID: 0000-0002-6920-1746

Martina Towers (M)

Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.

Qiang Zhang (Q)

Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.

Shuai Wu (S)

Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.

Aaron Havas (A)

Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA, USA.

Lu Wang (L)

Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-8896-0115

Shelley Berger (S)

Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0001-5398-4400

Peter D Adams (PD)

Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA, USA.
ORCID: 0000-0002-0684-1770

Bin Tian (B)

Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
ORCID: 0000-0001-8903-8256

Kazuko Nishikura (K)

Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.

Andrew V Kossenkov (AV)

Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.

Pingyu Liu (P)

Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA. pingyu_liu@fudan.edu.cn.
Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, China. pingyu_liu@fudan.edu.cn.
ORCID: 0000-0002-0498-1235

Rugang Zhang (R)

Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA. rzhang@wistar.org.
ORCID: 0000-0002-7255-2360

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Aminohydrolases › Nucleoside deaminases › Adenosine deaminase › ADAR1 downregulation by autophagy drives...
questionsmedicales.fr › Eucaryotes › Animaux › ADAR1 downregulation by autophagy drives...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › ADAR1 downregulation by autophagy drives...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › ADAR1 downregulation by autophagy drives...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Protéines inhibitrices des kinases cyclines-dépendantes › Inhibiteur p16 de kinase cycline-dépendante › ADAR1 downregulation by autophagy drives...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation négative › ADAR1 downregulation by autophagy drives...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › ADAR1 downregulation by autophagy drives...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › ADAR1 downregulation by autophagy drives...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Édition des ARN › ADAR1 downregulation by autophagy drives...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › ADAR1 downregulation by autophagy drives...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › ADAR1 downregulation by autophagy drives...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Sirtuines › Sirtuine-1 › ADAR1 downregulation by autophagy drives...