Gadolinium-free Magnetic Resonance Imaging of the Liver via an Oatp1-Targeted Manganese(III) Porphyrin.

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
19 Jul 2022
Historique:
entrez: 19 7 2022
pubmed: 20 7 2022
medline: 20 7 2022
Statut: aheadofprint

Résumé

Controversy surrounding gadolinium-based contrast agents (GBCAs) has rendered their continued utility highly contentious, but the liver-specific GBCA Gd(III) ethoxybenzyl-diethylene triamine pentaacetic acid (Gd(III)-EOB-DTPA) remains in use because it provides unique diagnostic information that could not be obtained by any other means. To address the need for an alternate liver-specific MRI probe, we synthesized Mn(III) 20-(4-ethoxyphenyl) porphyrin-5,10,15-tricarboxylate (Mn(III)TriCP-PhOEt), which exhibited significantly higher

Identifiants

DOI: 10.1021/acs.jmedchem.2c00500 PMID: 35852350
pubmed: 35852350
doi: 10.1021/acs.jmedchem.2c00500
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Nivin N Nyström (NN)

Department of Medical Biophysics, University of Western Ontario, London N6A 3K7, Ontario, Canada.
Imaging Research Laboratories, Robarts Research Institute, Western University, London N6A 3K7, Ontario, Canada.
ORCID: 0000-0001-6288-6060

Hanlin Liu (H)

Department of Chemistry, University of Toronto, Toronto M5S 1A4, Ontario, Canada.
Department of Physical and Environmental Sciences, University of Toronto, Toronto M5S 1A4, Ontario, Canada.

Francisco M Martinez (FM)

Imaging Research Laboratories, Robarts Research Institute, Western University, London N6A 3K7, Ontario, Canada.

Xiao-An Zhang (XA)

Department of Chemistry, University of Toronto, Toronto M5S 1A4, Ontario, Canada.
Department of Physical and Environmental Sciences, University of Toronto, Toronto M5S 1A4, Ontario, Canada.
ORCID: 0000-0001-9417-4228

Timothy J Scholl (TJ)

Department of Medical Biophysics, University of Western Ontario, London N6A 3K7, Ontario, Canada.
Imaging Research Laboratories, Robarts Research Institute, Western University, London N6A 3K7, Ontario, Canada.
Ontario Institute for Cancer Research, Toronto M5G 0A3, Ontario, Canada.

John A Ronald (JA)

Department of Medical Biophysics, University of Western Ontario, London N6A 3K7, Ontario, Canada.
Imaging Research Laboratories, Robarts Research Institute, Western University, London N6A 3K7, Ontario, Canada.
Lawson Health Research Institute, London N6C 2R5, Ontario, Canada.

Classifications MeSH