Acute intestinal necrosis due to multiple thrombosis in COVID-19 patient. Report of a case.

COVID-19 Intestinal ischemia Intestinal necrosis Thrombosis

Journal

Surgical case reports
ISSN: 2198-7793
Titre abrégé: Surg Case Rep
Pays: Germany
ID NLM: 101662125

Informations de publication

Date de publication:
19 Jul 2022
Historique:
received: 02 05 2022
accepted: 12 07 2022
entrez: 19 7 2022
pubmed: 20 7 2022
medline: 20 7 2022
Statut: epublish

Résumé

While thrombosis is a well-known complication of coronavirus disease 2019 (COVID-19) infection, reports on intestinal necrosis due to intestinal ischemia caused by thrombosis are extremely rare. We herein report a case of intestinal necrosis due to multiple thrombosis in a COVID-19 patient. The patient was a 64-year-old man. He was admitted to hospital after being diagnosed with COVID-19, the severity was classified as moderate II. Nasal High Flow™ management was conducted along with treatment with tocilizumab, remdesivir, and dexamethasone. Heparin was also administered due to high D-dimer values. As abdominal pain appeared from the 6th day of hospitalization, contrast-enhanced CT was performed, which confirmed multiple thrombosis in the aorta. However, no obvious intestinal ischemia was found. On the 10th day of hospitalization, the patient's abdominal pain was exacerbated. Upon re-evaluation by CT, he was diagnosed with perforative peritonitis due to ileal ischemic necrosis and emergency surgery was performed. Intraoperative examination revealed perforation due to necrosis at multiple sites in the ileum; thus, partial ileectomy was carried out. Pathological findings also revealed discontinuous multiple intestinal necrosis due to the frequent occurrence of thrombosis. Following surgery, the patient recuperated and was discharged after ventilator management and multimodal therapy at the ICU. Thrombosis due to COVID-19 complications is rare in the intestinal tract, but also occur. Its initial symptoms might not be captured by CT images, therefore caution is required.

Sections du résumé

BACKGROUND BACKGROUND
While thrombosis is a well-known complication of coronavirus disease 2019 (COVID-19) infection, reports on intestinal necrosis due to intestinal ischemia caused by thrombosis are extremely rare. We herein report a case of intestinal necrosis due to multiple thrombosis in a COVID-19 patient.
CASE PRESENTATION METHODS
The patient was a 64-year-old man. He was admitted to hospital after being diagnosed with COVID-19, the severity was classified as moderate II. Nasal High Flow™ management was conducted along with treatment with tocilizumab, remdesivir, and dexamethasone. Heparin was also administered due to high D-dimer values. As abdominal pain appeared from the 6th day of hospitalization, contrast-enhanced CT was performed, which confirmed multiple thrombosis in the aorta. However, no obvious intestinal ischemia was found. On the 10th day of hospitalization, the patient's abdominal pain was exacerbated. Upon re-evaluation by CT, he was diagnosed with perforative peritonitis due to ileal ischemic necrosis and emergency surgery was performed. Intraoperative examination revealed perforation due to necrosis at multiple sites in the ileum; thus, partial ileectomy was carried out. Pathological findings also revealed discontinuous multiple intestinal necrosis due to the frequent occurrence of thrombosis. Following surgery, the patient recuperated and was discharged after ventilator management and multimodal therapy at the ICU.
CONCLUSIONS CONCLUSIONS
Thrombosis due to COVID-19 complications is rare in the intestinal tract, but also occur. Its initial symptoms might not be captured by CT images, therefore caution is required.

Identifiants

pubmed: 35852719
doi: 10.1186/s40792-022-01495-6
pii: 10.1186/s40792-022-01495-6
pmc: PMC9295081
doi:

Types de publication

Journal Article

Langues

eng

Pagination

136

Informations de copyright

© 2022. The Author(s).

Références

J Atheroscler Thromb. 2021 Apr 1;28(4):406-416
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Lancet. 2020 Mar 28;395(10229):1054-1062
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pubmed: 32339221
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pubmed: 34761305
Ann Vasc Surg. 2021 Jan;70:290-294
pubmed: 32866580

Auteurs

Hirotsugu Morioka (H)

Department of Surgery, Tokyo Rinkai Hospital, 1-4-2 Rinkai-Cho, Edogawa-Ku, Tokyo, 134-0086, Japan. hirotsugu0419@yahoo.co.jp.

Michitoshi Goto (M)

Department of Surgery, Tokyo Rinkai Hospital, 1-4-2 Rinkai-Cho, Edogawa-Ku, Tokyo, 134-0086, Japan.

Haruka Tanaka (H)

Department of Surgery, Tokyo Rinkai Hospital, 1-4-2 Rinkai-Cho, Edogawa-Ku, Tokyo, 134-0086, Japan.

Hirotaka Momose (H)

Department of Surgery, Tokyo Rinkai Hospital, 1-4-2 Rinkai-Cho, Edogawa-Ku, Tokyo, 134-0086, Japan.

Kazuyoshi Fujino (K)

Department of Surgery, Tokyo Rinkai Hospital, 1-4-2 Rinkai-Cho, Edogawa-Ku, Tokyo, 134-0086, Japan.

Toshiaki Hagiwara (T)

Department of Surgery, Tokyo Rinkai Hospital, 1-4-2 Rinkai-Cho, Edogawa-Ku, Tokyo, 134-0086, Japan.

Jun Aoki (J)

Department of Surgery, Tokyo Rinkai Hospital, 1-4-2 Rinkai-Cho, Edogawa-Ku, Tokyo, 134-0086, Japan.

Michihiro Orihata (M)

Department of Surgery, Tokyo Rinkai Hospital, 1-4-2 Rinkai-Cho, Edogawa-Ku, Tokyo, 134-0086, Japan.

Kotaro Kaneko (K)

Department of Pediatric Surgery, Juntendo University, Tokyo, Japan.

Classifications MeSH