Non-micronized and micronized curcumin do not prevent the behavioral and neurochemical effects induced by acute stress in zebrafish.

Animals Antioxidants / pharmacology Curcumin / pharmacology Humans Oxidative Stress Thiobarbituric Acid Reactive Substances Zebrafish
Acute restraint stress Curcumin Open tank test Oxidative damage Zebrafish

Journal

Pharmacological reports : PR
ISSN: 2299-5684
Titre abrégé: Pharmacol Rep
Pays: Switzerland
ID NLM: 101234999

Informations de publication

Date de publication:
Aug 2022
Historique:
received: 29 04 2022
accepted: 06 07 2022
revised: 16 06 2022
pubmed: 20 7 2022
medline: 6 8 2022
entrez: 19 7 2022
Statut: ppublish

Résumé

Curcumin, a polyphenol extracted from the rhizome of Curcuma longa L. (Zingiberaceae), presents neuroprotective properties and can modulate neuronal pathways related to mental disorders. However, curcumin has low bioavailability, which can compromise its use. The micronization process can reduce mean particle diameter and improve this compound's bioavailability and therapeutic potential. We compared the behavioral (open tank test, OTT) and neurochemical (thiobarbituric acid reactive substances (TBARS) and non-protein thiols (NPSH) levels) effects of non-micronized curcumin (CUR, 10 mg/kg, ip) and micronized curcumin (MC, 10 mg/kg, ip) in adult zebrafish subjected to a 90-min acute restraint stress (ARS) protocol. ARS increased the time spent in the central area and the number of crossings and decreased the immobility time of the animals in the OTT. These results suggest an increase in locomotor activity and a decrease in thigmotaxis behavior. Both CUR and MC were not able to prevent these effects. Furthermore, ARS also induced oxidative damage by increasing TBARS and decreasing NPSH levels. Both CUR and MC did not prevent these effects. ARS-induced behavioral and biochemical effects were not blocked by any curcumin preparation. Therefore, we conclude that curcumin does not have acute anti-stress effects in zebrafish.

Sections du résumé

BACKGROUND BACKGROUND
Curcumin, a polyphenol extracted from the rhizome of Curcuma longa L. (Zingiberaceae), presents neuroprotective properties and can modulate neuronal pathways related to mental disorders. However, curcumin has low bioavailability, which can compromise its use. The micronization process can reduce mean particle diameter and improve this compound's bioavailability and therapeutic potential.
METHODS METHODS
We compared the behavioral (open tank test, OTT) and neurochemical (thiobarbituric acid reactive substances (TBARS) and non-protein thiols (NPSH) levels) effects of non-micronized curcumin (CUR, 10 mg/kg, ip) and micronized curcumin (MC, 10 mg/kg, ip) in adult zebrafish subjected to a 90-min acute restraint stress (ARS) protocol.
RESULTS RESULTS
ARS increased the time spent in the central area and the number of crossings and decreased the immobility time of the animals in the OTT. These results suggest an increase in locomotor activity and a decrease in thigmotaxis behavior. Both CUR and MC were not able to prevent these effects. Furthermore, ARS also induced oxidative damage by increasing TBARS and decreasing NPSH levels. Both CUR and MC did not prevent these effects.
CONCLUSION CONCLUSIONS
ARS-induced behavioral and biochemical effects were not blocked by any curcumin preparation. Therefore, we conclude that curcumin does not have acute anti-stress effects in zebrafish.

Identifiants

DOI: 10.1007/s43440-022-00389-6 PMID: 35852770
pubmed: 35852770
doi: 10.1007/s43440-022-00389-6
pii: 10.1007/s43440-022-00389-6
doi:

Substances chimiques

Antioxidants 0
Thiobarbituric Acid Reactive Substances 0
Curcumin IT942ZTH98

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

736-744

Informations de copyright

© 2022. The Author(s) under exclusive licence to Maj Institute of Pharmacology Polish Academy of Sciences.

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Auteurs

Adrieli Sachett (A)

Programa de Pós-Graduação Em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

Matheus Gallas-Lopes (M)

Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Sarmento Leite, 500/305, Porto Alegre, RS, 90050-170, Brazil.

Radharani Benvenutti (R)

Programa de Pós-Graduação Em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

Matheus Marcon (M)

Departamento de Bioquímica, Farmacologia e Fisiologia, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil.

Amanda M Linazzi (AM)

Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Sarmento Leite, 500/305, Porto Alegre, RS, 90050-170, Brazil.

Gean P S Aguiar (GPS)

Programa de Pós-Graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó (Unochapecó), Chapecó, SC, Brazil.

Ana P Herrmann (AP)

Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Sarmento Leite, 500/305, Porto Alegre, RS, 90050-170, Brazil.
Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

J Vladimir Oliveira (JV)

Programa de Pós-Graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó (Unochapecó), Chapecó, SC, Brazil.
Departamento de Engenharia Química e de Alimentos, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.

Anna M Siebel (AM)

Programa de Pós-Graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó (Unochapecó), Chapecó, SC, Brazil.

Angelo Piato (A)

Programa de Pós-Graduação Em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. angelopiato@ufrgs.br.
Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Sarmento Leite, 500/305, Porto Alegre, RS, 90050-170, Brazil. angelopiato@ufrgs.br.
ORCID: 0000-0001-5109-7306

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Non-micronized and micronized curcumin do not...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Non-micronized and micronized curcumin do not...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Diarylheptanoïdes › Curcumine › Non-micronized and micronized curcumin do not...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Non-micronized and micronized curcumin do not...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Non-micronized and micronized curcumin do not...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Substances réactives à l'acide thiobarbiturique › Non-micronized and micronized curcumin do not...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Non-micronized and micronized curcumin do not...