Xanthine oxidoreductase activity is correlated with hepatic steatosis.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
19 07 2022
19 07 2022
Historique:
received:
07
09
2021
accepted:
13
07
2022
entrez:
19
7
2022
pubmed:
20
7
2022
medline:
22
7
2022
Statut:
epublish
Résumé
The enzyme xanthine oxidoreductase (XOR) catalyzes the synthesis of uric acid (UA) from hypoxanthine and xanthine, which are products of purine metabolism starting from ribose-5-phosphate. Several studies suggested a relationship between hyperuricemia and hepatic steatosis; however, few previous studies have directly examined the relationship between XOR activity and hepatic steatosis. A total of 223 subjects with one or more cardiovascular risk factors were enrolled. The liver-to-spleen (L/S) ratio on computed tomography and the hepatic steatosis index (HSI) were used to assess hepatic steatosis. We used a newly developed highly sensitive assay based on [
Identifiants
pubmed: 35854080
doi: 10.1038/s41598-022-16688-0
pii: 10.1038/s41598-022-16688-0
pmc: PMC9296494
doi:
Substances chimiques
Xanthine
1AVZ07U9S7
Xanthine Dehydrogenase
EC 1.17.1.4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12282Informations de copyright
© 2022. The Author(s).
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