Aristolochic acid-associated cancers: a public health risk in need of global action.


Journal

Nature reviews. Cancer
ISSN: 1474-1768
Titre abrégé: Nat Rev Cancer
Pays: England
ID NLM: 101124168

Informations de publication

Date de publication:
10 2022
Historique:
accepted: 15 06 2022
pubmed: 20 7 2022
medline: 28 9 2022
entrez: 19 7 2022
Statut: ppublish

Résumé

Aristolochic acids (AAs) are a group of naturally occurring compounds present in many plant species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe nephropathy, and urological and hepatobiliary cancers (among others) that are often recurrent and characterized by the prominent mutational fingerprint of AA. However, herbal medicinal products that contain AA continue to be manufactured and marketed worldwide with inadequate regulation, and possible environmental exposure routes receive little attention. As the trade of food and dietary supplements becomes increasingly globalized, we propose that further inaction on curtailing AA exposure will have far-reaching negative effects on the disease trends of AA-associated cancers. Our Review aims to systematically present the historical and current evidence for the mutagenicity and carcinogenicity of AA, and the effect of removing sources of AA exposure on cancer incidence trends. We discuss the persisting challenges of assessing the scale of AA-related carcinogenicity, and the obstacles that must be overcome in curbing AA exposure and preventing associated cancers. Overall, this Review aims to strengthen the case for the implementation of prevention measures against AA's multifaceted, detrimental and potentially fully preventable effects on human cancer development.

Identifiants

pubmed: 35854147
doi: 10.1038/s41568-022-00494-x
pii: 10.1038/s41568-022-00494-x
doi:

Substances chimiques

Aristolochic Acids 0
aristolochic acid I 94218WFP5T

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

576-591

Subventions

Organisme : NIEHS NIH HHS
ID : R21 ES032855
Pays : United States
Organisme : NIEHS NIH HHS
ID : R56 ES029514
Pays : United States

Informations de copyright

© 2022. Springer Nature Limited.

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Auteurs

Samrat Das (S)

Epigenomics and Mechanisms Branch, International Agency for Research on Cancer WHO, Lyon, France.

Shefali Thakur (S)

Epigenomics and Mechanisms Branch, International Agency for Research on Cancer WHO, Lyon, France.
BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic.
Faculty of Science, Charles University, Prague, Czech Republic.

Michael Korenjak (M)

Epigenomics and Mechanisms Branch, International Agency for Research on Cancer WHO, Lyon, France.

Viktoriya S Sidorenko (VS)

Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA.

Felicia Fei-Lei Chung (FF)

Epigenomics and Mechanisms Branch, International Agency for Research on Cancer WHO, Lyon, France. feliciacfl@sunway.edu.my.
Department of Medical Sciences, School of Medical and Life Sciences, Sunway University, Petaling Jaya, Malaysia. feliciacfl@sunway.edu.my.

Jiri Zavadil (J)

Epigenomics and Mechanisms Branch, International Agency for Research on Cancer WHO, Lyon, France. ZavadilJ@iarc.who.int.

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