Bone formation in custom-made cranioplasty: evidence of early and sustained bone development in bioceramic calcium phosphate implants. Patient series.
CaP = calcium phosphate
IF = implant failure
SSI = surgical site infection
TBI = traumatic brain injury
bone formation
calcium phosphate
cranioplasty
implant failure
Journal
Journal of neurosurgery. Case lessons
ISSN: 2694-1902
Titre abrégé: J Neurosurg Case Lessons
Pays: United States
ID NLM: 9918227275606676
Informations de publication
Date de publication:
26 Apr 2021
26 Apr 2021
Historique:
received:
29
11
2020
accepted:
11
12
2020
entrez:
20
7
2022
pubmed:
26
4
2021
medline:
26
4
2021
Statut:
epublish
Résumé
Implant failure (IF) rates in cranioplasty remain high despite efforts to reduce the incidence. New biomaterials may be part of the solution for this problem. Formation of autologous bone in implants may reduce rates of infection and subsequent failure. Four patients with calcium phosphate implants supported by titanium mesh and undergoing surgery for reasons unrelated to IF were included in this series. Samples from the implants were microscopically examined. Pathological studies proved the formation of autologous bone in the calcium phosphate implants. Bone and blood vessel formation in the implants and diminished foreign body reaction to autologous bone may reduce the rates of IF.
Sections du résumé
BACKGROUND
BACKGROUND
Implant failure (IF) rates in cranioplasty remain high despite efforts to reduce the incidence. New biomaterials may be part of the solution for this problem. Formation of autologous bone in implants may reduce rates of infection and subsequent failure.
OBSERVATIONS
METHODS
Four patients with calcium phosphate implants supported by titanium mesh and undergoing surgery for reasons unrelated to IF were included in this series. Samples from the implants were microscopically examined. Pathological studies proved the formation of autologous bone in the calcium phosphate implants.
LESSONS
CONCLUSIONS
Bone and blood vessel formation in the implants and diminished foreign body reaction to autologous bone may reduce the rates of IF.
Identifiants
pubmed: 35855216
doi: 10.3171/CASE20133
pii: CASE20133
pmc: PMC9245784
doi:
Types de publication
Case Reports
Langues
eng
Pagination
CASE20133Informations de copyright
© 2021 The authors.
Déclaration de conflit d'intérêts
Disclosures The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.
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