Ψ-Footprinting approach for the identification of protein synthesis inhibitor producers.


Journal

NAR genomics and bioinformatics
ISSN: 2631-9268
Titre abrégé: NAR Genom Bioinform
Pays: England
ID NLM: 101756213

Informations de publication

Date de publication:
Sep 2022
Historique:
received: 10 02 2022
revised: 21 06 2022
accepted: 06 07 2022
entrez: 20 7 2022
pubmed: 21 7 2022
medline: 21 7 2022
Statut: epublish

Résumé

Today, one of the biggest challenges in antibiotic research is a targeted prioritization of natural compound producer strains and an efficient dereplication process to avoid undesired rediscovery of already known substances. Thereby, genome sequence-driven mining strategies are often superior to wet-lab experiments because they are generally faster and less resource-intensive. In the current study, we report on the development of a novel

Identifiants

pubmed: 35855324
doi: 10.1093/nargab/lqac055
pii: lqac055
pmc: PMC9290621
doi:

Types de publication

Journal Article

Langues

eng

Pagination

lqac055

Informations de copyright

© The Author(s) 2022. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.

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Auteurs

Franziska Handel (F)

Department of Microbiology/Biotechnology, Interfaculty Institute of Microbiology and Infection Medicine, Faculty of Science, University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.

Andreas Kulik (A)

Department of Microbiology/Biotechnology, Interfaculty Institute of Microbiology and Infection Medicine, Faculty of Science, University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.

Katharina W Wex (KW)

Department of Microbial Bioactive Compounds; Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen; Tübingen, Baden-Württemberg 72076, Germany.

Anne Berscheid (A)

Department of Microbial Bioactive Compounds; Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen; Tübingen, Baden-Württemberg 72076, Germany.

Julian S Saur (JS)

Biomolecular Chemistry, Institute of Organic Chemistry, University of Tübingen, Tübingen, Baden-Württemberg 72076, Germany.

Anika Winkler (A)

Center for Biotechnology (CeBiTec), Bielefeld University, Universitätsstraße 27, 33615 Bielefeld, Germany.

Daniel Wibberg (D)

Center for Biotechnology (CeBiTec), Bielefeld University, Universitätsstraße 27, 33615 Bielefeld, Germany.

Jörn Kalinowski (J)

Center for Biotechnology (CeBiTec), Bielefeld University, Universitätsstraße 27, 33615 Bielefeld, Germany.

Heike Brötz-Oesterhelt (H)

Department of Microbial Bioactive Compounds; Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen; Tübingen, Baden-Württemberg 72076, Germany.

Yvonne Mast (Y)

Department of Microbiology/Biotechnology, Interfaculty Institute of Microbiology and Infection Medicine, Faculty of Science, University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.

Classifications MeSH