Lipocalin 2 attenuates oligodendrocyte loss and immune cell infiltration in mouse models for multiple sclerosis.
Cup/EAE
MS lesions
cuprizone
degeneration
reactive astrocytes
Journal
Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
revised:
28
06
2022
received:
11
01
2022
accepted:
01
07
2022
pubmed:
21
7
2022
medline:
15
9
2022
entrez:
20
7
2022
Statut:
ppublish
Résumé
Multiple sclerosis (MS) is a central nervous system disease characterized by both degenerative and inflammatory processes. Various mediators are involved in the interplay of degeneration and innate immunity on one hand and peripheral adaptive immunity on the other hand. The secreted protein lipocalin 2 (LCN2) is an inflammatory modulator in a variety of pathologies. Although elevated intrathecal levels of LCN2 have been reported in MS patients, it's functional role is widely unknown. Here, we identified a subpopulation of astrocytes as a source of LCN2 in MS lesions and respective animal models. We investigated the functional role of LCN2 for both autoimmune and degenerative aspects in three MS mouse models including both wild type (WT) and Lcn2
Substances chimiques
Lipocalin-2
0
Lcn2 protein, mouse
126469-30-5
Cuprizone
5N16U7E0AO
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2188-2206Informations de copyright
© 2022 The Authors. GLIA published by Wiley Periodicals LLC.
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