Bone morphogenetic protein-4 system expression in human coronary artery endothelial and smooth muscle cells under dynamic flow: effect of medicated bioresorbable vascular scaffolds at low and normal shear stress.
Atherosclerosis
BMP4
BMPRs
BVS
Real-Time PCR
Shear stress
Journal
Heart and vessels
ISSN: 1615-2573
Titre abrégé: Heart Vessels
Pays: Japan
ID NLM: 8511258
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
01
02
2022
accepted:
06
07
2022
pubmed:
21
7
2022
medline:
21
10
2022
entrez:
20
7
2022
Statut:
ppublish
Résumé
Endothelial and smooth muscle cell dysfunction is an early event at the onset of atherosclerosis, a heterogeneous and multifactorial pathology of the vascular wall. Bone morphogenetic protein (BMP)-4, a mechanosensitive autocrine cytokine, and BMPR-1a, BMPR-1b, BMPR-2 specific receptors play a key role in atherosclerotic plaque formation and vascular calcification and BMP4 is regarded as a biomarker of endothelial cell activation. The study aimed to examine the BMP4 system expression by Real-Time PCR in Human Coronary Artery Endothelial (HCAECs) and Smooth Muscle Cells (HCASMCs) under different flow rates determining low or physiological shear stress in the presence/absence of medicated Bioresorbable Vascular Scaffold (BVS). The HCAEC and HCASMC were subjected to 1-10-20 dyne/cm
Identifiants
pubmed: 35857064
doi: 10.1007/s00380-022-02140-w
pii: 10.1007/s00380-022-02140-w
doi:
Substances chimiques
Everolimus
9HW64Q8G6G
RNA, Messenger
0
Biomarkers
0
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2137-2149Subventions
Organisme : Horizon 2020 Framework Programme
ID : 777119
Informations de copyright
© 2022. Springer Japan KK, part of Springer Nature.
Références
Glass CK, Witztum JL (2001) Atherosclerosis: the road ahead. Cell 104:503–516
pubmed: 11239408
doi: 10.1016/S0092-8674(01)00238-0
Stary HC, Chandler AB, Glagov S, Guyton JR, Insull W, Rosenfeld ME, Schaffer A, Schwartz CJ, Wagner WD, Wissler RW (1994) A definition of initial, fatty streak, and intermediate lesions of atherosclerosis: a report from the committee on vascular lesions of the council on arteriosclerosis. Circulation 89:2462–2478
pubmed: 8181179
doi: 10.1161/01.CIR.89.5.2462
Hansson GK (2005) Inflammation, atherosclerosis and coronary artery disease. N Engl J Med 352:1685–1695
pubmed: 15843671
doi: 10.1056/NEJMra043430
Ketelhuth DFJ, Hansson GK (2011) Cellular immunity, low-density lipoprotein and atherosclerosis: break of tolerance in the artery wall. Thromb Haemos 106:779–786
doi: 10.1160/TH11-05-0321
Frangos SG, Gahtan V, Sumpio B (1999) Localization of atherosclerosis: role of hemodynamics. Arch Surg 134:1142–1149
pubmed: 10522862
doi: 10.1001/archsurg.134.10.1142
Ross R, Glomset JA (1976) The pathogenesis of atherosclerosis (first of two parts). N Engl J Med 295:369–377
pubmed: 819830
doi: 10.1056/NEJM197608122950707
Ross R (1999) Atherosclerosis—an inflammatory disease. N Engl J Med 340:115–126
pubmed: 9887164
doi: 10.1056/NEJM199901143400207
Malek AM, Alper SL, Izumo S (1999) Hemodynamic shear stress and its role in atherosclerosis. JAMA 282:2035–2042
pubmed: 10591386
doi: 10.1001/jama.282.21.2035
Gimbrone MA, Guillermo GC (2016) Endothelial cell dysfunction and pathobiology of atherosclerosis. Circ Res 118:620–636
pubmed: 26892962
pmcid: 4762052
doi: 10.1161/CIRCRESAHA.115.306301
Miyauchi T, Masaki T (1999) Pathophysiology of endothelin in the cardiovascular system. Ann Rev Physiol 61:391–415
doi: 10.1146/annurev.physiol.61.1.391
Topper JN, Cai J, Falb D, Gimbrone MA (1996) Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc Natl Acad Sci 93:10417–10422
pubmed: 8816815
pmcid: 38399
doi: 10.1073/pnas.93.19.10417
Csiszar A, Lehoux S, Ungvari Z (2009) Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expression. Antioxid Redox Signal 11:1683–1697
pubmed: 19320562
pmcid: 2842584
doi: 10.1089/ars.2008.2401
Miyazono K, Kamiya Y, Morikawa M (2010) Bone morphogenetic protein receptors and signal transduction. J Biochem 147:35–51
pubmed: 19762341
doi: 10.1093/jb/mvp148
Sorescu GP, Sykes M, Weiss D, Platt MO, Saha A, Hwang J, Boyd N, Boo YC, Vega JD, Taylor WR, Jo H (2003) Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response. J Biol Chem 278:31128–31135
pubmed: 12766166
doi: 10.1074/jbc.M300703200
Sorescu GP, Song H, Tressel SL, Hwang J, Dikalov S, Smith DA, Boyd NL, Platt MO, Lassègue B, Griendling KK, Jo H (2004) Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a Nox1-based NADPH oxidase. Circ Res 95:773–779
pubmed: 15388638
doi: 10.1161/01.RES.0000145728.22878.45
Jo H, Song H, Mowbray A (2006) Role of NADPH oxidases in disturbed flow- and BMP4-induced inflammation and atherosclerosis. Antioxid Redox Sign 8:1609–1619
doi: 10.1089/ars.2006.8.1609
Lüscher TF, Steffel J, Eberli FR, Joner M, Nakazawa G, Tanner FC, Virmani R (2007) Drug-eluting stent and coronary thrombosis: biological mechanisms and clinical implications. Circulation 115:1051–1058
pubmed: 17325255
doi: 10.1161/CIRCULATIONAHA.106.675934
Buccheri D, Piraino D, Andolina G, Cortese B (2016) Understanding and managing in-stent restenosis: a review of clinical data, from pathogenesis to treatment. J Thorac Dis 8:E1150–E1162
pubmed: 27867580
pmcid: 5107494
doi: 10.21037/jtd.2016.10.93
Gogas BD (2014) Bioresorbable scaffolds for percutaneous coronary interventions. Glob Cardiol Sci Pract 2014:409–427
pubmed: 25780795
pmcid: 4355515
Brugaletta S, Heo JH, Garcia-Garcia HM, Farooq V, van Geuns RJ, de Bruyne B, Dudek D, Smits PC, Koolen J, McClean D, Dorange C, Veldhof S, Rapoza R, Onuma Y, Bruining N, Ormiston JA, Serruys PW (2012) Endothelial-dependent vasomotion in a coronary segment treated by ABSORB everolimus-eluting bioresorbable vascular scaffold system is related to plaque composition at the time of bioresorption of the polymer: indirect finding of vascular reparative therapy? Eur Heart J 33:1325–1333
pubmed: 22507972
doi: 10.1093/eurheartj/ehr466
Vozzi F, Cecchettini A, Cabiati M, Mg F, Aretini P, Del Ry S, Rocchiccioli S, Pelosi G (2021) Modulated molecular markers of restenosis and thrombosis byin-vitrovascular cells exposed to bioresorbable scaffolds. Biomed Mater 16(4):045039
doi: 10.1088/1748-605X/ac0401
Fejes Z, Czimmerer Z, Szük T, Póliska S, Horváth A, Balogh E, Jeney V, Váradi J, Fenyvesi F, Balla G, Édes I, Balla J, Kappelmayer J, Nagy B Jr (2018) Endothelial cell activation is attenuated by everolimus via transcriptional and post-transcriptional regulatory mechanisms after drug-eluting coronary stenting. PLoSOne 13:e0197890
doi: 10.1371/journal.pone.0197890
Tarbell JM, Shi ZD (2013) Effect of the glycocalyx layer on transmission of interstitial flow shear stress to embedded cells. Biomech Model Mechanobiol 12:111–121
pubmed: 22411016
doi: 10.1007/s10237-012-0385-8
Shi ZD, Tarbell JM (2011) Fluid flow mechano-transduction in vascular smooth muscle cells and fibroblasts. Ann Biomed Engin 39:1608–1619
doi: 10.1007/s10439-011-0309-2
Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, Vandesompele J, Wittwer CT (2009) The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem 55:611–622
pubmed: 19246619
doi: 10.1373/clinchem.2008.112797
Anders S, Huber W (2010) Differential expression analysis for sequence count data. Genome Biol 11:R106-112
pubmed: 20979621
pmcid: 3218662
doi: 10.1186/gb-2010-11-10-r106
Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15:550
pubmed: 25516281
pmcid: 4302049
doi: 10.1186/s13059-014-0550-8
Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3:research0034
pubmed: 12184808
pmcid: 126239
doi: 10.1186/gb-2002-3-7-research0034
Hansson GK, Hermansson A (2011) The immune system in atherosclerosis. Nature Immunol 12:204–212
doi: 10.1038/ni.2001
Skålén K, Gustafsson M, Rydberg EK, Hultén LM, Wiklund O, Innerarity TL, Borén J (2002) Subendothelial retention of atherogenic lipoproteins in early atherosclerosis. Nature 417:750–754
pubmed: 12066187
doi: 10.1038/nature00804
Ross R (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362:801–809
pubmed: 8479518
doi: 10.1038/362801a0
Epstein SE, Zhou YF, Zhu J (1999) Infection and atherosclerosis: emerging mechanistic paradigms. Circulation 100(4):e20–e28
pubmed: 10421626
doi: 10.1161/01.CIR.100.4.e20
Lamon BD, Hajjar DP (2008) Inflammation at the molecular interface of atherogenesis. Am J Pathol 173:1253–1264
pubmed: 18948435
pmcid: 2570117
doi: 10.2353/ajpath.2008.080442
Marzilli M, Merz CN, Boden WE, Bonow RO, Capozza PG, Chilian WM, DeMaria AN, Guarini G, Huqi A, Morrone D, Patel MR, Weintraub WS (2012) Obstructive coronary atherosclerosis and ischemic heart disease: an elusive link! J Am Coll Cardiol 60:951–956
pubmed: 22954239
doi: 10.1016/j.jacc.2012.02.082
Wong WT, Tian XY, Chen Y, Leung FP, Liu L, Lee HK, Ng CF, Xu A, Yao X, Vanhoutte PM, Tipoe GL, Huang Y (2010) Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension. Circ Res 107:984–991
pubmed: 20724703
doi: 10.1161/CIRCRESAHA.110.222794
Tian XY, Yung LH, Wong WT, Liu J, Leung FP, Liu L, Chen Y, Kong SK, Kwan KM, Ng SM, Lai PB, Yung LM, Yao X, Huang Y (2012) Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway. J Mol Cell Cardiol 52:237–244
pubmed: 22064324
doi: 10.1016/j.yjmcc.2011.10.013
Jo H, Song H (2005) Disturbed shear stress induces inflammation and atherosclerosis-role of BMP4 as a mechanosensitive and inflammatory cytokine. J Korean Diabetes 29:271–281
Yin W, Jo H, Voit EO (2010) Systems analysis of the role of bone morphogenic protein 4 in endothelial inflammation. Ann Biomed Eng 38:291–307
pubmed: 19851868
doi: 10.1007/s10439-009-9822-y
Csiszar A, Lehoux S, Ungvari Z (2009) Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expression. Antioxid Redox Signal 11:1683–1697
pubmed: 19320562
pmcid: 2842584
doi: 10.1089/ars.2008.2401
Cho A, Mitchell L, Koopmans D, Langille BL (1997) Effects of changes in blood flow rate on cell death and cell proliferation in carotid arteries of immature rabbits. Circ Res 81:328–337
pubmed: 9285634
doi: 10.1161/01.RES.81.3.328
Falk E (2006) Pathogenesis of atherosclerosis. J Am Coll Cardiol 47:C7-12
pubmed: 16631513
doi: 10.1016/j.jacc.2005.09.068
Walshe TE, Ferguson G, Connell P, O’Brien C, Cahill PA (2005) Pulsatile flow increases the expression of eNOS, ET-1, and prostacyclin in a novel in vitro coculture model of the retinal vasculature. Invest Ophthalmol Vis Sci 46:375–382
pubmed: 15623798
doi: 10.1167/iovs.04-0806
Urschel K, Cicha I, Daniel WG, Garlichs CD (2012) Shear stress patterns affect the secreted chemokine profile in endothelial cells. Clin Hemorheol Microcirc 50:143–152
pubmed: 22538542
doi: 10.3233/CH-2011-1450
Wang DM, Tarbell JM (1995) Modeling interstitial flow in an artery wall allows estimation of wall shear stress on smooth muscle cells. J Biomech Eng 117:358–363
pubmed: 8618390
doi: 10.1115/1.2794192
Kurdi A, Roth L, Van der Veken B, Van Dam D, De Deyn PP, De Doncker M, Neels H, De Meyer GRY, Martinet W (2019) Everolimus depletes plaque macrophages, abolishes intraplaque neovascularization and improves survival in mice with advanced atherosclerosis. Vascul Pharmacol 113:70–76
pubmed: 30590134
doi: 10.1016/j.vph.2018.12.004
Moore JE Jr, Berry JL (2002) Fluid and solid mechanical implications of vascular stenting. Ann Biomed Eng 30:498–508
pubmed: 12086001
doi: 10.1114/1.1458594
He Y, Duraiswamy N, Frank AO, Moore JE Jr (2005) Blood flow in stented arteries: a parametric comparison of strut design patterns in three dimensions. J Biomech Eng 127:637–647
pubmed: 16121534
doi: 10.1115/1.1934122
Mohler ER 3rd, Gannon F, Reynolds C, Zimmerman R, Keane MG, Kaplan FS (2001) Bone formation and inflammation in cardiac valves. Circulation 103:1522–1528
pubmed: 11257079
doi: 10.1161/01.CIR.103.11.1522
Dhore CR, Cleutjens JP, Lutgens E, Cleutjens KB, Geusens PP, Kitslaar PJ, Tordoir JH, Spronk HM, Vermeer C, Daemen MJ (2001) Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscler Thromb Vasc Biol 21:1998–2003
pubmed: 11742876
doi: 10.1161/hq1201.100229
Tarbell JM, Shi ZD, Dunn J, Jo H (2014) Fluid mechanics, arterial disease, and gene expression. Ann Rev Fluid Mech 46:591–614
doi: 10.1146/annurev-fluid-010313-141309
Cunningham KS, Gotlieb AI (2005) The role of shear stress in the pathogenesis of atherosclerosis. Lab Invest 85:9–23
pubmed: 15568038
doi: 10.1038/labinvest.3700215