Noncanonical activation of GLI signaling in SOX2
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
22 07 2022
22 07 2022
Historique:
entrez:
20
7
2022
pubmed:
21
7
2022
medline:
23
7
2022
Statut:
ppublish
Résumé
SRY (sex determining region Y)-box 2 (SOX2)-labeled cells play key roles in chemoresistance and tumor relapse; thus, it is critical to elucidate the mechanisms propagating them. Single-cell transcriptomic analyses of the most common malignant pediatric brain tumor, medulloblastoma (MB), revealed the existence of astrocytic
Identifiants
pubmed: 35857834
doi: 10.1126/sciadv.abj9138
pmc: PMC9299538
doi:
Substances chimiques
GLI1 protein, human
0
Hedgehog Proteins
0
SOX2 protein, human
0
SOXB1 Transcription Factors
0
Zinc Finger Protein GLI1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabj9138Subventions
Organisme : NINDS NIH HHS
ID : K01 NS119351
Pays : United States
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