Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community.

Dementia / epidemiology Humans Methionine Proportional Hazards Models S-Adenosylhomocysteine / metabolism S-Adenosylmethionine / metabolism

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
20 07 2022
Historique:
received: 06 01 2022
accepted: 06 07 2022
entrez: 20 7 2022
pubmed: 21 7 2022
medline: 23 7 2022
Statut: epublish

Résumé

We examined the association of serum s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH) (methionine metabolites), and their ratio on the risk of dementia and death in a community-dwelling population of older Japanese individuals. 1371 residents of Hisayama, Japan, aged 65 years or older and without dementia, were followed for a median of 10.2 years (2007-2017). We divided serum SAM, SAH, and SAM/SAH ratio into quartiles. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) of serum SAM, SAH, and SAM/SAH ratio levels on the risk of a composite outcome of all-cause dementia or death, and each outcome. During the follow-up, 635 participants developed all-cause dementia and/or died, of which 379 participants developed dementia and 394 deaths occurred. The multivariable-adjusted HRs of the composite outcome decreased significantly with increasing serum SAM levels (P for trend = 0.01), while they increased significantly with higher serum SAH levels (P for trend = 0.03). Higher serum SAM/SAH ratio levels were significantly associated with a lower risk of the composite outcome (P for trend = 0.002), as well as with lower risk of each outcome. Our findings suggest that the balance of methionine metabolites may closely associate with the risk of dementia and death.

Identifiants

DOI: 10.1038/s41598-022-16242-y PMID: 35859106 PMC: PMC9300687
pubmed: 35859106
doi: 10.1038/s41598-022-16242-y
pii: 10.1038/s41598-022-16242-y
pmc: PMC9300687
doi:

Substances chimiques

S-Adenosylmethionine 7LP2MPO46S
S-Adenosylhomocysteine 979-92-0
Methionine AE28F7PNPL

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12427

Informations de copyright

© 2022. The Author(s).

Références

Cardiovasc Res. 2012 Jul 15;95(2):241-50
pubmed: 22492673
Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11913-11918
pubmed: 27698120
PLoS One. 2014 Oct 27;9(10):e107756
pubmed: 25347725
Genes Dev. 2016 Jun 15;30(12):1409-22
pubmed: 27313316
Circulation. 2019 May 7;139(19):2260-2277
pubmed: 30773021
Protein Sci. 2019 Oct;28(10):1785-1796
pubmed: 31359525
Biomedicines. 2021 Jan 29;9(2):
pubmed: 33572965
Am J Clin Nutr. 2001 Jul;74(1):130-6
pubmed: 11451728
Neurology. 1984 Jul;34(7):939-44
pubmed: 6610841
Am J Clin Nutr. 2021 Oct 4;114(4):1360-1370
pubmed: 34192296
J Neurol Neurosurg Psychiatry. 2020 May;91(5):540-546
pubmed: 32234968
Clin Chem. 2000 Feb;46(2):265-72
pubmed: 10657384
J Nutr Biochem. 2011 Mar;22(3):242-51
pubmed: 20573497
FEBS Lett. 2003 Apr 24;541(1-3):145-8
pubmed: 12706835
Ther Clin Risk Manag. 2020 May 22;16:471-481
pubmed: 32547044
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Amino Acids. 2017 Dec;49(12):2091-2098
pubmed: 28929442
J Alzheimers Dis. 2017;58(2):549-558
pubmed: 28453493
Bone Marrow Transplant. 2020 Apr;55(4):675-680
pubmed: 31576022
Circ Res. 2001 Jun 8;88(11):1203-9
pubmed: 11397788
Mech Ageing Dev. 2006 May;127(5):444-50
pubmed: 16519922
Aging Cell. 2019 Dec;18(6):e13034
pubmed: 31460700
Neurobiol Aging. 2007 Dec;28(12):1834-9
pubmed: 16996649
Atherosclerosis. 2012 Mar;221(1):48-54
pubmed: 22204864
Neurology. 2017 May 16;88(20):1925-1932
pubmed: 28424272
Int J Biochem Cell Biol. 2000 Apr;32(4):391-5
pubmed: 10762064
Mol Cell Neurosci. 2005 Jan;28(1):195-204
pubmed: 15607954
Neurology. 1993 Feb;43(2):250-60
pubmed: 8094895
N Engl J Med. 2002 Feb 14;346(7):476-83
pubmed: 11844848
Neurodegener Dis. 2010;7(6):373-8
pubmed: 20523031
Mol Cell Neurosci. 2008 Apr;37(4):731-46
pubmed: 18243734
Neurobiol Aging. 2012 Jul;33(7):1482.e1-16
pubmed: 22221883
Circulation. 2013 Sep 10;128(11):1198-205
pubmed: 23902756
J Alzheimers Dis. 2010;20(4):997-1002
pubmed: 20413874
J Neurosci. 2007 Mar 14;27(11):2751-9
pubmed: 17360897
J Alzheimers Dis. 2020;77(4):1705-1715
pubmed: 32925070
JAMA Psychiatry. 2019 Nov 1;76(11):1198-1205
pubmed: 31339527
Brain Pathol. 2008 Jul;18(3):317-25
pubmed: 18462473

Auteurs

Akane Mihara (A)

Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Tomoyuki Ohara (T)

Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. ohara.tomoyuki.287@m.kyushu-u.ac.jp.
Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. ohara.tomoyuki.287@m.kyushu-u.ac.jp.

Jun Hata (J)

Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Sanmei Chen (S)

Global Health Nursing, Department of Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Takanori Honda (T)

Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Sonam Tamrakar (S)

Department of Agro-Environmental Sciences, Faculty of Agriculture, Kyusyu University, Fukuoka, Japan.

Akiko Isa (A)

Department of Agro-Environmental Sciences, Faculty of Agriculture, Kyusyu University, Fukuoka, Japan.

Dongmei Wang (D)

Department of Agro-Environmental Sciences, Faculty of Agriculture, Kyusyu University, Fukuoka, Japan.

Kuniyoshi Shimizu (K)

Department of Agro-Environmental Sciences, Faculty of Agriculture, Kyusyu University, Fukuoka, Japan.

Yoshinori Katakura (Y)

Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.

Koji Yonemoto (K)

Division of Biostatistics, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, Nishihara, Japan.

Tomohiro Nakao (T)

Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Takanari Kitazono (T)

Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Toshiharu Ninomiya (T)

Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Association of serum s-adenosylmethionine,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of serum s-adenosylmethionine,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Méthionine › Association of serum s-adenosylmethionine,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Modèles des risques proportionnels › Association of serum s-adenosylmethionine,...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Adénosine › S-(5'-Désoxy-adénosyl)homocystéine › Association of serum s-adenosylmethionine,...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Adénosine › Adémétionine › Association of serum s-adenosylmethionine,...