Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis.
CD137L
CD40L
CD8 immune response
Peritoneal carcinomatosis
cancer immunotherapy
Journal
Oncoimmunology
ISSN: 2162-402X
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
21
7
2022
pubmed:
22
7
2022
medline:
23
7
2022
Statut:
epublish
Résumé
Recombinant-modified vaccinia virus Ankara (rMVA) is known to elicit potent antitumor immune responses in preclinical models due to its inherent ability to activate the innate immune system and the activation of adaptive responses mediated by the expression of tumor antigens and costimulus-providing molecules, such as CD40L and CD137L. Here, we evaluated different rMVA vectors in preclinical peritoneal carcinomatosis models (ID8.OVA-
Identifiants
pubmed: 35859732
doi: 10.1080/2162402X.2022.2098657
pii: 2098657
pmc: PMC9291657
doi:
Substances chimiques
4-1BB Ligand
0
Tnfsf9 protein, mouse
0
CD40 Ligand
147205-72-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2098657Informations de copyright
© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
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