Advantages of ketamine in pediatric anesthesia.
anesthesia
intensive care
ketamine
pediatrics
sedation
Journal
Open medicine (Warsaw, Poland)
ISSN: 2391-5463
Titre abrégé: Open Med (Wars)
Pays: Poland
ID NLM: 101672167
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
02
2022
revised:
13
05
2022
accepted:
16
05
2022
entrez:
21
7
2022
pubmed:
22
7
2022
medline:
22
7
2022
Statut:
epublish
Résumé
Although ketamine is primarily used for induction and maintenance of general anesthesia, it also presents sedative, amnestic, anesthetics, analgesic, antihyperalgesia, neuroprotective, anti-inflammatory, immunomodulant, and antidepressant effects. Its unique pharmacodynamics and pharmacokinetic properties allow the use of ketamine in various clinical settings including sedation, ambulatory anesthesia, and intensive care practices. It has also adopted to manage acute and chronic pain management. Clinically, ketamine produces dissociative sedation, analgesia, and amnesia while maintaining laryngeal reflexes, with respiratory and cardiovascular stability. Notably, it does not cause respiratory depression, maintaining both the hypercapnic reflex and the residual functional capacity with a moderate bronchodilation effect. In the pediatric population, ketamine can be administered through practically all routes, making it an advantageous drug for the sedation required setting such as placement of difficult vascular access and in uncooperative and oppositional children. Consequently, ketamine is indicated in prehospital induction of anesthesia, induction of anesthesia in potentially hemodynamic unstable patients, and in patients at risk of bronchospasm. Even more, ketamine does not increase intracranial pressure, and it can be safely used also in patients with traumatic brain injuries. This article is aimed to provide a brief and practical summary of the role of ketamine in the pediatric field.
Identifiants
pubmed: 35859796
doi: 10.1515/med-2022-0509
pii: med-2022-0509
pmc: PMC9263896
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1134-1147Informations de copyright
© 2022 Alessandro Simonini et al., published by De Gruyter.
Déclaration de conflit d'intérêts
Conflict of interest: Dr Alessandro Vittori serve as Editor for Open Medicine, but it didn’t affected the peer-review process.
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