Clinical presentation, pregnancy complications, and outcomes of pregnant women with COVID-19 during the Omicron-dominant third wave in Mumbai, India.
Omicron
coronavirus disease 2019
maternal outcomes
pregnancy complications
severe acute respiratory syndrome coronavirus 2 infection
third wave
Journal
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
ISSN: 1879-3479
Titre abrégé: Int J Gynaecol Obstet
Pays: United States
ID NLM: 0210174
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
02
02
2022
accepted:
07
07
2022
pubmed:
22
7
2022
medline:
16
11
2022
entrez:
21
7
2022
Statut:
ppublish
Résumé
To study clinical presentation, disease severity, pregnancy complications, and maternal outcomes in women affected with coronavirus disease 2019 (COVID-19) during the third wave compared with the first and second waves of COVID-19. A retrospective, observational cohort study was conducted among 2058 pregnant and postpartum women with COVID-19 admitted during three wave periods at a tertiary care COVID-19-dedicated hospital. The number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) -infected pregnant and postpartum women with symptoms of COVID-19 was four times higher during the third wave compared with the first (odds ratio [OR] 4.6, 95% confidence interval [CI] 3.5-6.0, P < 0.001). There was a significantly lower proportion of pregnant and postpartum women with moderate to severe COVID-19 during the third wave (0.6%, 2/318) compared with those during the first wave (2.4%, 27/1143, P < 0.001) and second wave (14.4%, 86/597, P < 0.001). The intensive care/high dependency unit admissions during the third wave were significantly lower (2.5%, 8/318) than during the second wave (14.7%, 88/597; OR 0.2, 95% CI 0.1-0.3, P < 0.001) but similar to the first wave (2.4%, 27/1143). Decreased severity of COVID-19, reduced maternal mortality, and morbidity were reported in the third wave compared with the first wave and second wave of COVID-19 in the Mumbai Metropolitan Region, India. The study is registered with the Clinical Trial Registry of India (Registration no: CTRI/2020/05/025423).
Identifiants
pubmed: 35861246
doi: 10.1002/ijgo.14348
pmc: PMC9349384
doi:
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
968-973Informations de copyright
© 2022 International Federation of Gynecology and Obstetrics.
Références
World Health Organisation. Technical document: Enhancing response to Omicron SARS-CoV-2 variant. January 7, 2022. Accessed January 19, 2022. https://www.who.int/publications/m/item/enhancing-readiness-for-omicron-(b.1.1.529)-technical-brief-and-priority-actions-for-member-states
The Indian SARS-CoV-2 Genomics Consortium (INSACOG) weekly bulletin. January 3, 2022. Accessed January 24, 2022. https://dbtindia.gov.in/sites/default/files/INSACOG-WEEKLY%20Bulletin_03-01-2022.pdf
MoHFW. Home. Accessed January 20, 2022. https://www.mohfw.gov.in/
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