Abnormal antibodies to self-carbohydrates in SARS-CoV-2-infected patients.
Journal
PNAS nexus
ISSN: 2752-6542
Titre abrégé: PNAS Nexus
Pays: England
ID NLM: 9918367777906676
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
07
12
2021
accepted:
19
05
2022
entrez:
22
7
2022
pubmed:
23
7
2022
medline:
23
7
2022
Statut:
epublish
Résumé
Our immune system is critical for preventing and treating SARS-CoV-2 infections, but aberrant immune responses can have deleterious effects. While antibodies to glycans could recognize the virus and influence the clinical outcome, little is known about their roles. Using a carbohydrate antigen microarray, we profiled serum antibodies in healthy control subjects and COVID-19 patients from two separate cohorts. COVID-19 patients had numerous autoantibodies to self-glycans, including antiganglioside antibodies that can cause neurological disorders. Additionally, nearly all antiglycan IgM signals were lower in COVID-19 patients, indicating a global dysregulation of this class of antibodies. Autoantibodies to certain
Identifiants
pubmed: 35865361
doi: 10.1093/pnasnexus/pgac062
pii: pgac062
pmc: PMC9291223
doi:
Types de publication
Journal Article
Langues
eng
Pagination
pgac062Subventions
Organisme : NIGMS NIH HHS
ID : U54 GM062116
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Published by Oxford University Press on behalf of the National Academy of Sciences 2021.
Références
J Clin Invest. 2020 Sep 1;130(9):4791-4797
pubmed: 32525844
Methods Mol Biol. 2015;1331:27-40
pubmed: 26169733
Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1749-58
pubmed: 24733910
JCI Insight. 2021 Jan 11;6(1):
pubmed: 33232303
PLoS One. 2015 Mar 25;10(3):e0119298
pubmed: 25807519
Mol Cell Proteomics. 2021;20:100058
pubmed: 33077685
Clin Infect Dis. 2020 Nov 5;71(8):1930-1934
pubmed: 32306047
Front Immunol. 2020 Aug 07;11:1949
pubmed: 32849654
Nat Med. 2020 Oct;26(10):1636-1643
pubmed: 32839624
Clin Microbiol Infect. 2020 Nov;26(11):1448-1449
pubmed: 32712242
Biochim Biophys Acta. 2008 Mar;1780(3):538-45
pubmed: 18029096
N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
JCI Insight. 2022 May 9;7(9):
pubmed: 35349483
J Med Virol. 2020 Oct;92(10):2004-2010
pubmed: 32330303
Sci Rep. 2016 Jan 19;6:19509
pubmed: 26781493
JAMA. 2020 Aug 25;324(8):782-793
pubmed: 32648899
Bioinformatics. 2020 Jun 1;36(11):3613-3614
pubmed: 32170934
Clin Infect Dis. 2021 Jul 15;73(2):328-331
pubmed: 32750119
Nat Med. 2020 Nov;26(11):1708-1713
pubmed: 32934372
ACS Omega. 2018 Dec 31;3(12):16882-16891
pubmed: 30613809
N Engl J Med. 2020 Oct 29;383(18):1724-1734
pubmed: 32871063
BMC Genomics. 2004 Feb 03;5(1):10
pubmed: 15018648
Curr Protoc Chem Biol. 2010 Mar 1;2(1):37-53
pubmed: 23836542
AIDS. 2017 Oct 23;31(16):2199-2209
pubmed: 28926408
Pathogens. 2021 Apr 06;10(4):
pubmed: 33917609
J Neurol. 2021 Mar;268(3):751-757
pubmed: 32734353
Clin Cancer Res. 2013 Mar 1;19(5):1290-9
pubmed: 23362327
Science. 2011 Nov 25;334(6059):1097-103
pubmed: 21998254
J Phys Chem B. 2020 Aug 20;124(33):7128-7137
pubmed: 32559081
J Clin Microbiol. 2020 Jul 23;58(8):
pubmed: 32350047
Sci Rep. 2021 May 26;11(1):11025
pubmed: 34040014
Nat Commun. 2020 Nov 13;11(1):5761
pubmed: 33188185
Clin Exp Immunol. 1986 Nov;66(2):481-9
pubmed: 3815902
JAMA. 2020 Apr 28;323(16):1582-1589
pubmed: 32219428
J Oleo Sci. 2011;60(10):537-44
pubmed: 21937853
Front Immunol. 2020 Jul 10;11:1708
pubmed: 32754163
Cell Chem Biol. 2016 Dec 22;23(12):1515-1525
pubmed: 27889407
Cell Mol Immunol. 2020 Apr;17(4):313-322
pubmed: 32152553
J Biomed Sci. 2019 Sep 6;26(1):67
pubmed: 31492138
JAMA. 2020 Aug 11;324(6):603-605
pubmed: 32644129
Science. 2020 Oct 23;370(6515):
pubmed: 32972996
J Neurol. 2021 Apr;268(4):1133-1170
pubmed: 32840686
Science. 2020 Sep 4;369(6508):
pubmed: 32669297
Ann Hematol. 2020 Sep;99(9):2113-2118
pubmed: 32656591
Glycobiology. 2009 Jul;19(7):676-92
pubmed: 19240270
Transfusion. 2020 Aug;60(8):1883-1884
pubmed: 32562280
Antibodies (Basel). 2020 Jun 22;9(2):
pubmed: 32580274
Brain Behav Immun. 2021 Mar;93:415-419
pubmed: 33359380
Neurology. 2020 Aug 4;95(5):e601-e605
pubmed: 32303650
J Med Virol. 2021 Apr;93(4):2065-2075
pubmed: 33009829
Anal Chem. 2021 Feb 2;93(4):2003-2009
pubmed: 33406838
J Proteome Res. 2009 Sep;8(9):4301-10
pubmed: 19624168
Life Sci. 2020 Sep 15;257:118063
pubmed: 32652139
Sci Transl Med. 2020 Nov 18;12(570):
pubmed: 33139519
Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9490-9496
pubmed: 32253318
Open Forum Infect Dis. 2020 Aug 27;7(9):ofaa387
pubmed: 32989419
Biochim Biophys Acta. 1994 Dec 9;1197(3):237-55
pubmed: 7819267
Glycobiology. 2020 Dec 9;30(12):981-988
pubmed: 32363391
J Gen Intern Med. 2021 Mar;36(3):738-745
pubmed: 33443703
Cell. 2020 Nov 12;183(4):982-995.e14
pubmed: 32991843
Front Microbiol. 2021 Feb 11;12:641460
pubmed: 33643275
Science. 2020 Jul 17;369(6501):330-333
pubmed: 32366695
Cancer Res. 1986 Mar;46(3):1553-61
pubmed: 3510728
Drugs Context. 2020 Jun 11;9:
pubmed: 32587625
J Neurol Neurosurg Psychiatry. 2020 Dec;91(12):1361-1362
pubmed: 32859744
ACS Cent Sci. 2020 Oct 28;6(10):1722-1734
pubmed: 33140034
Cell Host Microbe. 2020 Oct 7;28(4):586-601.e6
pubmed: 32841605
Cell Discov. 2020 May 4;6:31
pubmed: 32377375
Brain. 2002 Dec;125(Pt 12):2591-625
pubmed: 12429589
Shock. 2020 Nov;54(5):586-594
pubmed: 32604223
Nat Rev Immunol. 2020 Jun;20(6):363-374
pubmed: 32346093
Sci Immunol. 2021 Aug 19;6(62):
pubmed: 34413139
Nature. 2011 Sep 22;477(7365):466-70
pubmed: 21849977
J Physiol. 2009 Aug 15;587(Pt 16):3979-99
pubmed: 19564393
Cell Death Differ. 2020 May;27(5):1451-1454
pubmed: 32205856
Sci Transl Med. 2021 Sep 22;13(612):eabh2624
pubmed: 34429372