Off-Stoichiometric Thiol-Ene Chemistry to Dendritic Nanogel Therapeutics.
cancer treatment
dendritic nanogel
drug delivery
nanomedicine
Journal
Advanced functional materials
ISSN: 1616-301X
Titre abrégé: Adv Funct Mater
Pays: Germany
ID NLM: 101190390
Informations de publication
Date de publication:
02 May 2019
02 May 2019
Historique:
received:
21
09
2018
revised:
28
01
2019
entrez:
22
7
2022
pubmed:
2
5
2019
medline:
2
5
2019
Statut:
ppublish
Résumé
A novel platform of dendritic nanogels is herein presented, capitalizing on the self-assembly of allyl-functional polyesters based on dendritic-linear-dendritic amphiphiles followed by simple cross-linking with complementary monomeric thiols via UV initiated off-stoichiometric thiol-ene chemistry. The facile approach enabled multigram creation of allyl reactive nanogel precursors, in the size range of 190-295 nm, being readily available for further modifications to display a number of core functionalities while maintaining the size distribution and characteristics of the master batch. The nanogels are evaluated as carriers of a spread of chemotherapeutics by customizing the core to accommodate each individual cargo. The resulting nanogels are biocompatible, displaying diffusion controlled release of cargo, maintained therapeutic efficacy, and decreased cargo toxic side effects. Finally, the nanogels are found to successfully deliver pharmaceuticals into a 3D pancreatic spheroids tumor model.
Identifiants
pubmed: 35865651
doi: 10.1002/adfm.201806693
pii: ADFM201806693
pmc: PMC9286377
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1806693Informations de copyright
© 2019 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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