Reduced Rates of Post-Transplant Recurrent Hepatocellular Carcinoma in Non-Alcoholic Steatohepatitis: A Propensity Score Matched Analysis.
Organ Procurement and Transplantation Network
United Network for Organ Sharing
hepatocellular carcinoma
non-alcoholic steatohepatitis
recurrence
Journal
Transplant international : official journal of the European Society for Organ Transplantation
ISSN: 1432-2277
Titre abrégé: Transpl Int
Pays: Switzerland
ID NLM: 8908516
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
11
2021
accepted:
13
06
2022
entrez:
22
7
2022
pubmed:
23
7
2022
medline:
26
7
2022
Statut:
epublish
Résumé
Non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) has become the second leading cause of HCC-related liver transplantation in the United States. This study investigated post-transplant recurrence and survival for patients transplanted for NASH-related HCC compared to non-NASH HCC etiologies. Retrospective review of the United Network for Organ Sharing (UNOS) Organ Procurement and Transplantation Network (OPTN) database identified 7,461 patients with HCC-1,405 with underlying NASH and 6,086 with non-NASH underlying diseases. After propensity score matching (PSM) to account for patient- and tumor-related confounders 1,175 remained in each group. Primary outcomes assessed were recurrence rate and recurrence-free survival. Recurrent malignancy at 5 years post-transplant was lower in NASH compared to non-NASH patients (5.80 vs. 9.41%,
Identifiants
pubmed: 35865863
doi: 10.3389/ti.2022.10175
pii: 10175
pmc: PMC9294152
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
10175Informations de copyright
Copyright © 2022 Lamm, Altshuler, Patel, Shaheen, Amante, Civan, Maley, Frank, Ramirez, Glorioso, Shah, Dang and Bodzin.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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