Cyclic Adenosine Monophosphate (cAMP)-Dependent Phosphodiesterase Inhibition Promotes Bone Anabolism Through CD8
ANABOLICS
CELLS OF BONE
OSTEOBLASTS
OSTEOIMMUNOLOGY
SYSTEMS BIOLOGY–BONE INTERACTORS
THERAPEUTICS
Journal
JBMR plus
ISSN: 2473-4039
Titre abrégé: JBMR Plus
Pays: England
ID NLM: 101707013
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
25
02
2022
revised:
22
04
2022
accepted:
05
05
2022
entrez:
22
7
2022
pubmed:
23
7
2022
medline:
23
7
2022
Statut:
epublish
Résumé
Cyclic adenosine monophosphate (cAMP)-dependent phosphodiesterase (PDE) inhibitors such as pentoxifylline (PTX) suppress cAMP degradation and promote cAMP-dependent signal transduction. PDE inhibitors increase bone formation and bone mass in preclinical models and are used clinically to treat psoriatic arthritis by targeting inflammatory mediators including activated T cells. T cell activation requires two signals: antigen-dependent CD3-activation, which stimulates cAMP production; and CD28 co-stimulation, which downregulates cAMP-signaling, through PDE activation. PDE-inhibitors consequently suppress T cell activation by disrupting CD28 co-stimulation. Interestingly, we have reported that when CD8
Identifiants
pubmed: 35866149
doi: 10.1002/jbm4.10636
pii: JBM410636
pmc: PMC9289889
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10636Subventions
Organisme : BLRD VA
ID : I01 BX000105
Pays : United States
Informations de copyright
© 2022 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Déclaration de conflit d'intérêts
All authors declare that they have no conflicts of interest.
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