Development of Parkinson Disease and Its Relationship with Incidentally Discovered White Matter Disease and Covert Brain Infarction in a Real-World Cohort.
Journal
Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
18
07
2022
received:
28
03
2022
accepted:
20
07
2022
pubmed:
23
7
2022
medline:
21
9
2022
entrez:
22
7
2022
Statut:
ppublish
Résumé
This study aimed to examine the relationship between covert cerebrovascular disease, comprised of covert brain infarction and white matter disease, discovered incidentally in routine care, and subsequent Parkinson disease. Patients were ≥50 years and received neuroimaging for non-stroke indications in the Kaiser Permanente Southern California system from 2009 to 2019. Natural language processing identified incidentally discovered covert brain infarction and white matter disease and classified white matter disease severity. The Parkinson disease outcome was defined as 2 ICD diagnosis codes. 230,062 patients were included (median follow-up 3.72 years). A total of 1,941 Parkinson disease cases were identified (median time-to-event 2.35 years). Natural language processing identified covert cerebrovascular disease in 70,592 (30.7%) patients, 10,622 (4.6%) with covert brain infarction and 65,814 (28.6%) with white matter disease. After adjustment for known risk factors, white matter disease was associated with Parkinson disease (hazard ratio 1.67 [95%CI, 1.44, 1.93] for patients <70 years and 1.33 [1.18, 1.50] for those ≥70 years). Greater severity of white matter disease was associated with increased incidence of Parkinson disease(/1,000 person-years), from 1.52 (1.43, 1.61) in patients without white matter disease to 4.90 (3.86, 6.13) in those with severe disease. Findings were robust when more specific definitions of Parkinson disease were used. Covert brain infarction was not associated with Parkinson disease (adjusted hazard ratio = 1.05 [0.88, 1.24]). Incidentally discovered white matter disease was associated with subsequent Parkinson disease, an association strengthened with younger age and increased white matter disease severity. Incidentally discovered covert brain infarction did not appear to be associated with subsequent Parkinson disease. ANN NEUROL 2022;92:620-630.
Identifiants
pubmed: 35866711
doi: 10.1002/ana.26458
pmc: PMC9489676
mid: NIHMS1825509
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
620-630Subventions
Organisme : NINDS NIH HHS
ID : R01 NS102233
Pays : United States
Informations de copyright
© 2022 American Neurological Association.
Références
JAMA Neurol. 2022 Apr 01;79(4):359-369
pubmed: 35254398
Nat Rev Neurol. 2011 Apr;7(4):229-36
pubmed: 21343896
Neurology. 2021 Sep 28;97(13):e1313-e1321
pubmed: 34376505
J Biomed Inform. 2020 Sep;109:103526
pubmed: 32768446
Mov Disord. 2015 Oct;30(12):1600-11
pubmed: 26474317
Parkinsonism Relat Disord. 2017 Oct;43:33-37
pubmed: 28688982
Neurology. 2020 Oct 13;95(15):e2095-e2108
pubmed: 32817391
PLoS Med. 2018 Aug 21;15(8):e1002640
pubmed: 30130376
Ann Neurol. 2012 Dec;72(6):893-901
pubmed: 23071076
J Neurol Neurosurg Psychiatry. 1993 Oct;56(10):1090-5
pubmed: 8410008
Parkinsonism Relat Disord. 2010 Jan;16(1):31-5
pubmed: 19640771
BMC Neurosci. 2017 Jun 8;18(1):48
pubmed: 28595572
Mov Disord. 2001 Jan;16(1):119-23
pubmed: 11215570
Mov Disord. 2021 Jun;36(6):1420-1429
pubmed: 33682937
PLoS Med. 2017 Jun 13;14(6):e1002314
pubmed: 28609445
Mov Disord. 2012 Oct;27(12):1506-12
pubmed: 23015464
Mov Disord. 2020 Feb;35(2):236-244
pubmed: 31785021
PLoS One. 2015 Jun 29;10(6):e0131778
pubmed: 26121579
Clin Geriatr Med. 2020 Feb;36(1):1-12
pubmed: 31733690
NPJ Parkinsons Dis. 2021 Apr 1;7(1):33
pubmed: 33795693
Cerebrovasc Dis. 2022 Jun 27;:1-5
pubmed: 35760063
Stroke. 1994 Feb;25(2):318-27
pubmed: 8303738
Behav Res Ther. 2017 Nov;98:4-18
pubmed: 27890222
Int J Mol Sci. 2021 May 07;22(9):
pubmed: 34066951
Ann Neurol. 2019 Oct;86(4):572-581
pubmed: 31464350
Stroke. 2018 Feb;49(2):363-369
pubmed: 29311270
Neurology. 2015 Nov 3;85(18):1569-77
pubmed: 26446068
Perm J. 2012 Summer;16(3):37-41
pubmed: 23012597
Ann Clin Transl Neurol. 2020 Feb;7(2):229-238
pubmed: 32032471
Stroke. 1991 Mar;22(3):312-8
pubmed: 2003301
Mov Disord. 2012 May;27(6):771-4
pubmed: 22314772
Mov Disord Clin Pract. 2020 Apr 30;7(6):629-638
pubmed: 32775508
Parkinsonism Relat Disord. 2013 Aug;19(8):761-3
pubmed: 23660543
Neurology. 2019 Apr 16;92(16):e1821-e1830
pubmed: 30894446
Parkinsonism Relat Disord. 2018 Apr;49:9-16
pubmed: 29310988
J Neurol Neurosurg Psychiatry. 2014 Jan;85(1):31-7
pubmed: 23828833
BMC Neurol. 2021 May 11;21(1):189
pubmed: 33975556
Lancet. 2017 Oct 7;390(10103):1664-1675
pubmed: 28781108
J Parkinsons Dis. 2018;8(s1):S3-S8
pubmed: 30584159
J Neurol Sci. 2021 Jul 15;426:117481
pubmed: 33975191
Parkinsonism Relat Disord. 2009 Jan;15(1):24-9
pubmed: 18403246
Brain Behav Immun. 2013 Mar;29:51-61
pubmed: 23232501
J Neurol Neurosurg Psychiatry. 2020 Oct;91(10):1046-1054
pubmed: 32934108
J Neurol. 2021 Sep;268(9):3144-3179
pubmed: 32378035
Mov Disord. 2019 Oct;34(10):1464-1470
pubmed: 31412427
JMIR Med Inform. 2019 Apr 21;7(2):e12109
pubmed: 31066686