Increased pyroptosis activation in white matter microglia is associated with neuronal loss in ALS motor cortex.
Amyotrophic Lateral Sclerosis
/ pathology
Animals
DNA-Binding Proteins
/ metabolism
Disease Models, Animal
Humans
Inflammasomes
/ metabolism
Mice
Mice, Inbred NOD
Mice, Transgenic
Microglia
/ pathology
Motor Cortex
/ metabolism
Motor Neurons
/ pathology
NLR Family, Pyrin Domain-Containing 3 Protein
/ metabolism
Pyroptosis
White Matter
/ pathology
Amyotrophic lateral sclerosis
Inflammasome
Pyroptosis
Transactive response DNA-binding protein
Journal
Acta neuropathologica
ISSN: 1432-0533
Titre abrégé: Acta Neuropathol
Pays: Germany
ID NLM: 0412041
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
13
04
2022
accepted:
01
07
2022
revised:
01
07
2022
pubmed:
23
7
2022
medline:
19
8
2022
entrez:
22
7
2022
Statut:
ppublish
Résumé
Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motor neurons in the motor cortex, brainstem, and spinal cord. Although ALS is considered a motor neuron disorder, neuroinflammation also plays an important role. Recent evidence in ALS disease models indicates activation of the inflammasome and subsequent initiation of pyroptosis, an inflammatory type of cell death. In this study, we determined the expression and distribution of the inflammasome and pyroptosis effector proteins in post-mortem brain and spinal cord from ALS patients (n = 25) and controls (n = 19), as well as in symptomatic and asymptomatic TDP-43
Identifiants
pubmed: 35867112
doi: 10.1007/s00401-022-02466-9
pii: 10.1007/s00401-022-02466-9
doi:
Substances chimiques
DNA-Binding Proteins
0
Inflammasomes
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
393-411Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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