Age-Associated B Cell Features of the Murine High-Grade B Cell Lymphoma Bc.DLFL1 and Its Extranodal Expansion in Abdominal Adipose Tissues.

Animals B-Lymphocytes / metabolism Lymphoma, Large B-Cell, Diffuse / pathology Mesentery / metabolism Mice Mice, Inbred BALB C Tumor Microenvironment

Journal

Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R

Informations de publication

Date de publication:
15 06 2022
Historique:
received: 04 10 2021
accepted: 16 04 2022
entrez: 22 7 2022
pubmed: 23 7 2022
medline: 27 7 2022
Statut: ppublish

Résumé

Diffuse large B cell lymphoma comprises a heterogeneous group of B cell-derived tumors, with different degrees of aggressiveness, as defined by their cellular origin and tissue microenvironment. Using the spontaneous Bc.DLFL1 lymphoma originating from a BALB/c mouse as a diffuse large B cell lymphoma model, in this study we demonstrate that the lymphoma cells display surface phenotype, IgH V-region somatic mutations, transcription factor characteristics and in vivo location to splenic extrafollicular regions of age-associated B cells (ABCs), corresponding to T-bet

Identifiants

DOI: 10.4049/jimmunol.2100956 PMID: 35867673
pubmed: 35867673
pii: jimmunol.2100956
doi: 10.4049/jimmunol.2100956
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2866-2876

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2022 by The American Association of Immunologists, Inc.

Auteurs

Xinkai Jia (X)

Department of Immunology and Biotechnology, Clinical Center, University of Pécs, Pécs, Hungary.
Lymphoid Organogenesis Research Group, Szentágothai Research Center, University of Pécs, Pécs, Hungary.

Judit Bene (J)

Department of Medical Genetics, Clinical Center, University of Pécs, Pécs, Hungary.

Noémi Balázs (N)

Department of Immunology and Biotechnology, Clinical Center, University of Pécs, Pécs, Hungary.

Katalin Szabó (K)

Department of Immunology and Biotechnology, Clinical Center, University of Pécs, Pécs, Hungary.
ORCID: 0000-0001-6569-3862

Gergely Berta (G)

Department of Medical Biology and Central Electron Microscope Laboratory, Medical School, University of Pécs, Pécs, Hungary; and.

Róbert Herczeg (R)

Bioinformatics Research Group, Szentágothai Research Center, University of Pécs, Pécs, Hungary.

Attila Gyenesei (A)

Bioinformatics Research Group, Szentágothai Research Center, University of Pécs, Pécs, Hungary.

Péter Balogh (P)

Department of Immunology and Biotechnology, Clinical Center, University of Pécs, Pécs, Hungary; balogh.peter@pte.hu.
Lymphoid Organogenesis Research Group, Szentágothai Research Center, University of Pécs, Pécs, Hungary.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Age-Associated B Cell Features of the Murine...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Age-Associated B Cell Features of the Murine...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › Lymphome malin non hodgkinien › Lymphome B › Lymphome B diffus à grandes cellules › Age-Associated B Cell Features of the Murine...
questionsmedicales.fr › Régions du corps › Tronc › Abdomen › Cavité abdominale › Mésentère › Age-Associated B Cell Features of the Murine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Age-Associated B Cell Features of the Murine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Age-Associated B Cell Features of the Murine...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Age-Associated B Cell Features of the Murine...