Sex difference in human olfactory sensitivity is associated with plasma adiponectin.


Journal

Hormones and behavior
ISSN: 1095-6867
Titre abrégé: Horm Behav
Pays: United States
ID NLM: 0217764

Informations de publication

Date de publication:
09 2022
Historique:
received: 31 03 2022
revised: 04 07 2022
accepted: 05 07 2022
pubmed: 23 7 2022
medline: 5 10 2022
entrez: 22 7 2022
Statut: ppublish

Résumé

Energy deprivation as well as hormones that regulate appetite and eating can influence olfactory function. This study investigated olfactory sensitivity for a food-related and a non-food odour prior to and after a meal, and its relationship to the energy-regulating hormones ghrelin and adiponectin. The olfactory sensitivity for orange and rose (PEA) odour in healthy, normal-weight volunteers (19 women, 45 men, 1 undisclosed individual) was not affected by the consumption of a meal. Olfactory sensitivity was not associated with concentrations of circulating ghrelin. However, olfactory sensitivity was higher for women than for men, indicating better olfactory performance. This difference between women and men was related to concentrations of plasma adiponectin, an adipose-specific hormone. Adiponectin may thus explain why sex differences in olfactory sensitivity emerge, and may also account for some of the inconsistencies in previous findings on sex differences. Our findings add to the limited literature on the impact of stomach and adipose tissue-derived hormones on olfactory sensitivity. Further studies are needed to establish a causal link between circulating adiponectin and a sex difference in olfactory sensitivity.

Identifiants

pubmed: 35868172
pii: S0018-506X(22)00129-5
doi: 10.1016/j.yhbeh.2022.105235
pii:
doi:

Substances chimiques

Adiponectin 0
Ghrelin 0
Leptin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

105235

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Auteurs

Daniela M Pfabigan (DM)

Dept. of Behavioural Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway; Morbid Obesity Centre, Department of Medicine, Vestfold Hospital Trust, Tønsberg, Norway.

Cecilia Vezzani (C)

Dept. of Behavioural Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.

Per Medbøe Thorsby (PM)

Hormone Laboratory, Dep of Medical Biochemistry and Biochemical Endocrinology and Metabolism Research Group, Oslo University Hospital, Aker, Oslo, Norway.

Uta Sailer (U)

Dept. of Behavioural Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address: uta.sailer@medisin.uio.no.

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Classifications MeSH