Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness.

Asthma / drug therapy Axonemal Dyneins / genetics Bronchodilator Agents / therapeutic use Child Ethnicity Genome-Wide Association Study Hispanic or Latino / genetics Humans Mexican Americans / genetics Minority Groups Polymorphism, Single Nucleotide

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
22 07 2022
Historique:
received: 24 03 2022
accepted: 11 07 2022
entrez: 22 7 2022
pubmed: 23 7 2022
medline: 27 7 2022
Statut: epublish

Résumé

Variability in response to short-acting β

Identifiants

DOI: 10.1038/s41598-022-16488-6 PMID: 35869121 PMC: PMC9307508
pubmed: 35869121
doi: 10.1038/s41598-022-16488-6
pii: 10.1038/s41598-022-16488-6
pmc: PMC9307508
doi:

Substances chimiques

Bronchodilator Agents 0
Axonemal Dyneins EC 3.6.4.2
DNAH5 protein, human EC 3.6.4.2

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12514

Subventions

Organisme : NHGRI NIH HHS
ID : UM1 HG008901
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117004
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118267
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113003
Pays : United States
Organisme : NIMHD NIH HHS
ID : P60 MD006902
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL120393
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117626
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128439
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI079139
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141992
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120393
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG009080
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135156
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133433
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES013508
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG008956
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL079966
Pays : United States
Organisme : NIMHD NIH HHS
ID : R01 MD010443
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL132825
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES015794
Pays : United States

Informations de copyright

© 2022. The Author(s).

Références

Mol Cell Biol. 2012 Aug;32(15):3132-9
pubmed: 22645315
Pharmacogenomics J. 2014 Feb;14(1):41-7
pubmed: 23508266
J Allergy Clin Immunol. 2018 May;141(5):1659-1667.e11
pubmed: 28927820
Pediatr Pulmonol. 2019 Nov;54(11):1694-1703
pubmed: 31424170
PLoS Med. 2020 Mar 23;17(3):e1003062
pubmed: 32203549
J Clin Invest. 1997 Dec 15;100(12):3184-8
pubmed: 9399966
Am J Respir Crit Care Med. 2015 Jul 1;192(1):47-56
pubmed: 25918834
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Asthma Res Pract. 2016 Jun 20;2:10
pubmed: 27965778
Eur Respir J. 2017 May 1;49(5):
pubmed: 28461288
BMC Genet. 2015 Dec 03;16:138
pubmed: 26634245
Front Immunol. 2019 May 29;10:821
pubmed: 31191511
Nat Genet. 2016 Oct;48(10):1279-83
pubmed: 27548312
Nat Genet. 2002 Feb;30(2):143-4
pubmed: 11788826
Nat Commun. 2018 May 8;9(1):1825
pubmed: 29739930
N Engl J Med. 2011 Sep 29;365(13):1173-83
pubmed: 21991891
Eur Respir J. 2019 Dec 19;54(6):
pubmed: 31619474
PLoS One. 2013 Sep 02;8(9):e72899
pubmed: 24023788
Am J Hum Genet. 2011 May 13;88(5):586-98
pubmed: 21565292
Nat Genet. 2016 Oct;48(10):1284-1287
pubmed: 27571263
Am J Respir Crit Care Med. 2015 Mar 1;191(5):530-7
pubmed: 25562107
Nat Commun. 2015 Nov 30;6:10069
pubmed: 26616563
Am J Respir Crit Care Med. 2018 Jun 15;197(12):1552-1564
pubmed: 29509491
Chest. 2008 Nov;134(5):981-989
pubmed: 18583517
Eur Respir J. 2005 Nov;26(5):948-68
pubmed: 16264058
Nat Genet. 2018 Jan;50(1):42-53
pubmed: 29273806
Am J Hum Genet. 2019 Jan 3;104(1):65-75
pubmed: 30595370
Psychiatr Genet. 2010 Jun;20(3):135-6
pubmed: 20414139
Lancet Respir Med. 2019 Jan;7(1):20-34
pubmed: 30552067
J Allergy Clin Immunol. 2008 Nov;122(5):921-928.e4
pubmed: 18848350
Nat Genet. 2018 Sep;50(9):1335-1341
pubmed: 30104761
Genome Biol. 2018 Oct 4;19(1):151
pubmed: 30286773
Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5
pubmed: 23193258
Pharmacogenomics J. 2014 Aug;14(4):365-71
pubmed: 24418963
Nat Genet. 2011 May;43(5):491-8
pubmed: 21478889
Hum Mol Genet. 2008 Jun 1;17(11):1569-77
pubmed: 18270208
Pharmacogenet Genomics. 2008 May;18(5):373-82
pubmed: 18408560
Nat Genet. 2013 Jun;45(6):580-5
pubmed: 23715323
Bioinformatics. 2011 Aug 1;27(15):2156-8
pubmed: 21653522
Bioinformatics. 2019 Dec 15;35(24):5346-5348
pubmed: 31329242
Am J Respir Cell Mol Biol. 2012 Oct;47(4):536-42
pubmed: 22679274
J Allergy Clin Immunol. 2014 Feb;133(2):370-8
pubmed: 23992748
Eur Respir J. 2013 Mar;41(3):716-26
pubmed: 22903959
Cytokine. 2009 Apr;46(1):111-8
pubmed: 19237298
Circ Res. 2018 Feb 2;122(3):433-443
pubmed: 29212778
Hum Mol Genet. 2005 Jun 15;14(12):1671-7
pubmed: 15879435
Am J Respir Crit Care Med. 2004 Feb 1;169(3):386-92
pubmed: 14617512
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
J Allergy Clin Immunol. 2003 Nov;112(5):870-6
pubmed: 14610472
Nucleic Acids Res. 2019 Jan 8;47(D1):D766-D773
pubmed: 30357393
Pharmacogenomics. 2016 Jul;17(10):1145-1158
pubmed: 27355804
Thorax. 2012 Jan;67(1):49-53
pubmed: 21953064
Am J Respir Crit Care Med. 2008 Oct 1;178(7):688-94
pubmed: 18617639
Biol Psychiatry. 2007 May 15;61(10):1121-6
pubmed: 17346679
J Allergy Clin Immunol. 2007 Mar;119(3):654-61
pubmed: 17336615
J Allergy Clin Immunol. 2017 Oct;140(4):996-1003.e7
pubmed: 28167095
PLoS Genet. 2018 Aug 10;14(8):e1007586
pubmed: 30096133
J Allergy Clin Immunol. 2010 Sep;126(3):618-25.e1-2
pubmed: 20673984
J Asthma. 2007 Oct;44(8):639-48
pubmed: 17943575
PLoS Genet. 2012 Jul;8(7):e1002824
pubmed: 22792082
Pediatr Res. 2006 Mar;59(3):418-22
pubmed: 16492982
Am J Respir Crit Care Med. 2013 Apr 1;187(7):690-6
pubmed: 23348973
AMIA Annu Symp Proc. 2018 Dec 05;2018:1338-1347
pubmed: 30815178
AMIA Annu Symp Proc. 2022 Feb 21;2021:601-610
pubmed: 35308900
Control Clin Trials. 1999 Feb;20(1):91-120
pubmed: 10027502
Nature. 2021 Feb;590(7845):290-299
pubmed: 33568819
Pediatr Pulmonol. 2009 Jul;44(7):649-54
pubmed: 19514054
Am J Respir Crit Care Med. 2013 Aug 1;188(3):309-18
pubmed: 23750510
J Allergy Clin Immunol. 2012 Jun;129(6):1484-90.e6
pubmed: 22560959
Pharmacogenomics J. 2013 Apr;13(2):130-6
pubmed: 22212731

Auteurs

Jaehyun Joo (J)

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, 402 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104, USA.

Angel C Y Mak (ACY)

Department of Medicine, University of California, San Francisco, UCSF, 1550 4th Street, Bldg 19B, San Francisco, CA, 94158, USA.

Shujie Xiao (S)

Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.

Patrick M Sleiman (PM)

Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Donglei Hu (D)

Department of Medicine, University of California, San Francisco, UCSF, 1550 4th Street, Bldg 19B, San Francisco, CA, 94158, USA.

Scott Huntsman (S)

Department of Medicine, University of California, San Francisco, UCSF, 1550 4th Street, Bldg 19B, San Francisco, CA, 94158, USA.

Celeste Eng (C)

Department of Medicine, University of California, San Francisco, UCSF, 1550 4th Street, Bldg 19B, San Francisco, CA, 94158, USA.

Mengyuan Kan (M)

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, 402 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104, USA.

Avantika R Diwakar (AR)

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, 402 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104, USA.

Jessica A Lasky-Su (JA)

Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Scott T Weiss (ST)

Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Joanne E Sordillo (JE)

PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Ann C Wu (AC)

PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Michelle Cloutier (M)

Department of Pediatrics, University of Connecticut, Farmington, CT, USA.

Glorisa Canino (G)

Behavioral Sciences Research Institute, University of Puerto Rico, San Juan, PR, USA.

Erick Forno (E)

Division of Pediatric Pulmonary Medicine, UMPC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.

Juan C Celedón (JC)

Division of Pediatric Pulmonary Medicine, UMPC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.

Max A Seibold (MA)

Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA.

Hakon Hakonarson (H)

Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

L Keoki Williams (LK)

Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.

Esteban G Burchard (EG)

Department of Medicine, University of California, San Francisco, UCSF, 1550 4th Street, Bldg 19B, San Francisco, CA, 94158, USA. esteban.burchard@ucsf.edu.
Department of Bioengineering and Therapeutic Sciences, University of Californica, San Francisco, CA, USA. esteban.burchard@ucsf.edu.

Blanca E Himes (BE)

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, 402 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104, USA. bhimes@pennmedicine.upenn.edu.

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Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Genome-wide association study in minority...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Acid anhydride hydrolases › Adenosine triphosphatases › Moteurs moléculaires › Dynéines de l'axonème › Genome-wide association study in minority...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents de l'appareil respiratoire › Antiasthmatiques › Bronchodilatateurs › Genome-wide association study in minority...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Genome-wide association study in minority...
questionsmedicales.fr › Caractéristiques de la population › Ethnies › Genome-wide association study in minority...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genome-wide association study in minority...
questionsmedicales.fr › Personnes › Nord-Américains › Groupes de population aux États-Unis › Hispanique ou Latino › Genome-wide association study in minority...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genome-wide association study in minority...
questionsmedicales.fr › Personnes › Nord-Américains › Groupes de population aux États-Unis › Hispanique ou Latino › Américain origine mexicaine › Genome-wide association study in minority...
questionsmedicales.fr › Sciences sociales › Sociologie › Facteurs sociologiques › Minorités › Genome-wide association study in minority...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Genome-wide association study in minority...