Smooth muscle cell specific NEMO deficiency inhibits atherosclerosis in ApoE

Animals Apolipoproteins E / metabolism Atherosclerosis / pathology Endothelial Cells / metabolism Inflammation / pathology Intracellular Signaling Peptides and Proteins / genetics Mice Mice, Inbred C57BL Mice, Knockout Myocytes, Smooth Muscle / metabolism NF-kappa B / metabolism Plaque, Atherosclerotic / pathology

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
22 07 2022
Historique:
received: 23 05 2022
accepted: 14 07 2022
entrez: 22 7 2022
pubmed: 23 7 2022
medline: 27 7 2022
Statut: epublish

Résumé

The development of atherosclerotic plaques is the result of a chronic inflammatory response coordinated by stromal and immune cellular components of the vascular wall. While endothelial cells and leukocytes are well-recognised mediators of inflammation in atherosclerosis, the role of smooth muscle cells (SMCs) remains incompletely understood. Here we aimed to address the role of canonical NF-κB signalling in SMCs in the development of atherosclerosis. We investigated the role of NF-κB signalling in SMCs in atherosclerosis by employing SMC-specific ablation of NEMO, an IKK complex subunit that is essential for canonical NF-κB activation, in ApoE

Identifiants

DOI: 10.1038/s41598-022-16737-8 PMID: 35869246 PMC: PMC9307802
pubmed: 35869246
doi: 10.1038/s41598-022-16737-8
pii: 10.1038/s41598-022-16737-8
pmc: PMC9307802
doi:

Substances chimiques

Apoe protein, mouse 0
Apolipoproteins E 0
Intracellular Signaling Peptides and Proteins 0
NEMO protein, mouse 0
NF-kappa B 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12538

Informations de copyright

© 2022. The Author(s).

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Auteurs

Takashi Imai (T)

Institute for Genetics, University of Cologne, 50931, Cologne, Germany.
Centre for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931, Cologne, Germany.

Trieu-My Van (TM)

Institute for Genetics, University of Cologne, 50931, Cologne, Germany.
Centre for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931, Cologne, Germany.

Manolis Pasparakis (M)

Institute for Genetics, University of Cologne, 50931, Cologne, Germany. pasparakis@uni-koeln.de.
Centre for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne, Germany. pasparakis@uni-koeln.de.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931, Cologne, Germany. pasparakis@uni-koeln.de.
CECAD Research Center, Institute for Genetics, University of Cologne, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany. pasparakis@uni-koeln.de.

Apostolos Polykratis (A)

Institute for Genetics, University of Cologne, 50931, Cologne, Germany.
Centre for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931, Cologne, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Smooth muscle cell specific NEMO deficiency...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Smooth muscle cell specific NEMO deficiency...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › Smooth muscle cell specific NEMO deficiency...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Smooth muscle cell specific NEMO deficiency...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Smooth muscle cell specific NEMO deficiency...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Smooth muscle cell specific NEMO deficiency...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Smooth muscle cell specific NEMO deficiency...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Smooth muscle cell specific NEMO deficiency...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Smooth muscle cell specific NEMO deficiency...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes du muscle lisse › Smooth muscle cell specific NEMO deficiency...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Smooth muscle cell specific NEMO deficiency...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Plaque d'athérosclérose › Smooth muscle cell specific NEMO deficiency...