Metabolic activity via
Colorectal cancer
Metabolic tumor volume
Microsatellite instability
Positron emission tomography
Journal
BMC cancer
ISSN: 1471-2407
Titre abrégé: BMC Cancer
Pays: England
ID NLM: 100967800
Informations de publication
Date de publication:
22 Jul 2022
22 Jul 2022
Historique:
received:
23
08
2021
accepted:
05
07
2022
entrez:
22
7
2022
pubmed:
23
7
2022
medline:
27
7
2022
Statut:
epublish
Résumé
Identification of microsatellite instability high (MSI-H) colorectal cancer (CRC) is crucial for screening patients most likely to benefit from immunotherapy. We aim to investigate whether the metabolic characteristics is related to MSI status and can be used to predict the MSI-H CRC. A retrospective analysis was conducted on 420 CRC patients who were identified via [ Of 420 colorectal cancers, 44 exhibited a high incidence of MSI. Both MTV and TLG were significantly higher in MSI-H group compared with the MSS group (P = 0.004 and P = 0.010, respectively). Logistic regression analysis indicated that CRC with MSI-H were related to younger age (P = 0.013), primary lesion located at right hemi-colon (P < 0.001) and larger MTV on PET/CT imaging (P = 0.019). MTV more than 32.19 of colorectal cancer was linked to the presence of MSI (P = 0.019). Tumor metabolic burden were higher in MSI-H CRC which may be useful for predicting the MSI status of CRC patient and thus aid in determination of immunotherapy for patients with CRC.
Identifiants
pubmed: 35869469
doi: 10.1186/s12885-022-09871-z
pii: 10.1186/s12885-022-09871-z
pmc: PMC9306059
doi:
Substances chimiques
Radiopharmaceuticals
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
808Subventions
Organisme : Zhejiang Province Public Welfare Technology Application Research Project
ID : LGF22H180013
Organisme : National Natural Science Foundation of China
ID : 82071957
Organisme : Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support
ID : XMLX202120
Informations de copyright
© 2022. The Author(s).
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