[Suppression of HMGB1 inhibits neuronal autophagy and apoptosis to improve neurological deficits in rats following intracerebral hemorrhage].
apoptosis
autophagy
high-mobility group box1
intracerebral hemorrhage
neuronal cells
Journal
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
ISSN: 1673-4254
Titre abrégé: Nan Fang Yi Ke Da Xue Xue Bao
Pays: China
ID NLM: 101266132
Informations de publication
Date de publication:
20 Jul 2022
20 Jul 2022
Historique:
entrez:
23
7
2022
pubmed:
24
7
2022
medline:
27
7
2022
Statut:
ppublish
Résumé
To investigate the effect of suppressing high-mobility group box 1 (HMGB1) on neuronal autophagy and apoptosis in rats after intracerebral hemorrhage (ICH) in rats. Rat models of ICH induced by intracerebral striatum injection of 0.2 U/mL collagenase Ⅳ were treated with 1 mg/kg anti-HMGB1 mAb or a control anti-IgG mAb injected via the tail immediately and at 6 h after the operation ( The rat models of ICH showed significantly increased mNSS ( Down- regulation of HMGB1 by anti-HMGB1 improves neurological functions of rats after ICH possibly by inhibiting autophagy and apoptosis of the neurons.
Identifiants
pubmed: 35869769
doi: 10.12122/j.issn.1673-4254.2022.07.13
pmc: PMC9308864
doi:
Substances chimiques
Apoptosis Regulatory Proteins
0
Beclin-1
0
Proto-Oncogene Proteins c-bcl-2
0
bcl-2-Associated X Protein
0
Caspase 3
EC 3.4.22.-
Types de publication
Journal Article
Langues
chi
Sous-ensembles de citation
IM
Pagination
1050-1056Références
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