Individual target pharmacokinetic/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia.
Journal
The Journal of antimicrobial chemotherapy
ISSN: 1460-2091
Titre abrégé: J Antimicrob Chemother
Pays: England
ID NLM: 7513617
Informations de publication
Date de publication:
28 10 2022
28 10 2022
Historique:
received:
08
04
2022
accepted:
24
06
2022
pubmed:
24
7
2022
medline:
2
11
2022
entrez:
23
7
2022
Statut:
ppublish
Résumé
Critical illness reduces β-lactam pharmacokinetic/pharmacodynamic (PK/PD) attainment. We sought to quantify PK/PD attainment in patients with hospital-acquired pneumonia. Meropenem plasma PK data (n = 70 patients) were modelled, PK/PD attainment rates were calculated for empirical and definitive targets, and between-patient variability was quantified [as a coefficient of variation (CV%)]. Attainment of 100% T>4×MIC was variable for both empirical (CV% = 92) and directed (CV% = 33%) treatment. Individualization is required to achieve suggested PK/PD targets in critically ill patients.
Identifiants
pubmed: 35869779
pii: 6648979
doi: 10.1093/jac/dkac245
pmc: PMC10205601
doi:
Substances chimiques
Meropenem
FV9J3JU8B1
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2956-2959Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL153122
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG049665
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI135964
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001422
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL154998
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149883
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA221848
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL159356
Pays : United States
Investigateurs
Hiam Abdala-Valencia
(H)
Michael J Alexander
(MJ)
Jason M Arnold
(JM)
Joseph Isaac Bailey
(JI)
Elizabeth T Bartom
(ET)
Ankit Bharat
(A)
Thomas Bolig
(T)
Nicole Borkowski
(N)
G R Scott Budinger
(GRS)
Navdeep S Chandel
(NS)
Rebecca K Clepp
(RK)
John Coleman
(J)
Michael J Cuttica
(MJ)
Thaddeus R Cybulski
(TR)
Jane E Dematte
(JE)
Joseph S Deters
(JS)
Justin A Fiala
(JA)
Gaurav T Gadhvi
(GT)
Catherine A Gao
(CA)
Khalilah L Gates
(KL)
Samuel W M Gatesy
(SWM)
Ritika Giri
(R)
Pearl D Go
(PD)
Cara J Gottardi
(CJ)
Rogan A Grant
(RA)
Stefan J Green
(SJ)
Elen Gusman
(E)
Estefany R Guzman
(ER)
SeungHye Han
(S)
Erica Marie Hartmann
(EM)
Curt M Horvath
(CM)
Mishaal Hukamdad
(M)
Sydney M Hyder
(SM)
Manu Jain
(M)
Anthony M Joudi
(AM)
Rachel B Kadar
(RB)
Ravi Kalhan
(R)
David W Kamp
(DW)
Manoj Kandpal
(M)
David A Kidd
(DA)
Hermon Kihshen
(H)
Zasu M Klug
(ZM)
Erin A Korth
(EA)
Jacqueline M Kruser
(JM)
Romy Lawrence
(R)
Emily M Leibenguth
(EM)
Anne R Levenson
(AR)
Lindsey D Gradone
(LD)
Gabrielle Y Liu
(GY)
Jon W Lomasney
(JW)
Theresa A Lombardo
(TA)
Ziyan Lu
(Z)
Amy Ludwig
(A)
Ali Mahmoud
(A)
Elizabeth S Malsin
(ES)
Nikolay S Markov
(NS)
Alexandra C McQuattie-Pimentel
(AC)
Daniel Meza
(D)
Felix Leonardo Morales
(FL)
Luisa Morales-Nebreda
(L)
Richard I Morimoto
(RI)
Ruben J Mylvaganam
(RJ)
Prasanth Nannapaneni
(P)
Luís A Nunes Amaral
(LAN)
Radhika Patel
(R)
Lorenzo L Pesce
(LL)
Chiagozie O Pickens
(CO)
Yuliya Politanska
(Y)
Taylor A Poor
(TA)
Michelle Hinsch Prickett
(MH)
Melissa Querrey
(M)
Luke V Rasmussen
(LV)
Ziyou Ren
(Z)
Karen M Ridge
(KM)
Madeline L Rosenbaum
(ML)
Sharon R Rosenberg
(SR)
Timothy Rowe
(T)
Susan R Russell
(SR)
Marc A Sala
(MA)
Daniel Schneider
(D)
Clara J Schroedl
(CJ)
Katharine Secunda
(K)
Patrick C Seed
(PC)
Karolina J Senkow
(KJ)
Todd Shamaly
(T)
Elisheva D Shanes
(ED)
Jiaxian Shen
(J)
Ali Shilatifard
(A)
Lango Sichizya
(L)
Benjamin D Singer
(BD)
Sean Smith
(S)
Peter H S Sporn
(PHS)
Justin Starren
(J)
Thomas Stoeger
(T)
Jack Sumner
(J)
Suchitra Swaminathan
(S)
Jacob I Sznajder
(JI)
Heliodoro Tejedor Navarro
(HT)
Lindsey N Textor
(LN)
Sanket Thakkar
(S)
Rade Tomic
(R)
Betty Tran
(B)
Kaitlyn Vitale
(K)
Ajay A Wagh
(AA)
James M Walter
(JM)
Firas Wehbe
(F)
Deborah R Winter
(DR)
Alexis Rose Wolfe
(AR)
Lisa F Wolfe
(LF)
Anjana V Yeldandi
(AV)
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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