Treponema pallidum outer membrane proteins: current status and prospects.
Treponema pallidum
diagnosis
pathogenesis
vaccine
Journal
Pathogens and disease
ISSN: 2049-632X
Titre abrégé: Pathog Dis
Pays: United States
ID NLM: 101595366
Informations de publication
Date de publication:
27 09 2022
27 09 2022
Historique:
received:
30
01
2022
revised:
30
05
2022
accepted:
20
07
2022
pubmed:
24
7
2022
medline:
30
9
2022
entrez:
23
7
2022
Statut:
ppublish
Résumé
The outer membrane proteins (OMPs) of Treponema pallidum subsp. pallidum (T. pallidum), the etiological agent of the sexually transmitted disease syphilis, have long been a hot research topic. Despite many hurdles to studying the pathogen, especially the inability to manipulate T. pallidum in vitro genetically, considerable progress has been made in elucidating the structure, pathogenesis and functions of T. pallidum OMPs. In this review, we integrate this information to garner fresh insights into the role of OMPs in the diagnosis, pathogenicity and vaccine development of T. pallidum. Collectively, the essential scientific discussions herein should provide a framework for understanding the current status and prospects of T. pallidum OMPs.
Identifiants
pubmed: 35869970
pii: 6649208
doi: 10.1093/femspd/ftac023
pii:
doi:
Substances chimiques
Bacterial Outer Membrane Proteins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of FEMS.