Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode.

Humans Retrospective Studies Optic Neuritis / diagnosis Retina / diagnostic imaging Tomography, Optical Coherence / methods Retinal Degeneration / pathology Multiple Sclerosis / complications Vision Disorders Atrophy / pathology
Children MOGAD Multiple sclerosis Myelin-oligodendrocyte-glycoprotein IgG Optic neuritis Optical coherence tomography Pediatric patients Visual evoked potential

Journal

Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161

Informations de publication

Date de publication:
Dec 2022
Historique:
received: 16 05 2022
accepted: 23 06 2022
revised: 22 06 2022
pubmed: 24 7 2022
medline: 2 11 2022
entrez: 23 7 2022
Statut: ppublish

Résumé

Optic neuritis (ON) is the most prevalent manifestation of pediatric multiple sclerosis (MS Patients were retrospectively identified in eight tertial referral centers. OCT, VEP and high/low-contrast visual acuity (HCVA/LCVA) have been investigated > 6 months after the first ON. Prevalence of pathological OCT findings was identified based on data of 144 age-matched healthy controls. Thirteen MOGAD First MOGAD-ON results in a more severe global peripapillary atrophy compared to predominantly temporal thinning in MS-ON. Nasal pRNFL allows differentiation between both diseases with the highest accuracy, supporting the additional diagnostic value of OCT in children with ON.

Sections du résumé

BACKGROUND BACKGROUND
Optic neuritis (ON) is the most prevalent manifestation of pediatric multiple sclerosis (MS
METHODS METHODS
Patients were retrospectively identified in eight tertial referral centers. OCT, VEP and high/low-contrast visual acuity (HCVA/LCVA) have been investigated > 6 months after the first ON. Prevalence of pathological OCT findings was identified based on data of 144 age-matched healthy controls.
RESULTS RESULTS
Thirteen MOGAD
CONCLUSION CONCLUSIONS
First MOGAD-ON results in a more severe global peripapillary atrophy compared to predominantly temporal thinning in MS-ON. Nasal pRNFL allows differentiation between both diseases with the highest accuracy, supporting the additional diagnostic value of OCT in children with ON.

Identifiants

DOI: 10.1007/s00415-022-11256-y PMID: 35869995 PMC: PMC9618526
pubmed: 35869995
doi: 10.1007/s00415-022-11256-y
pii: 10.1007/s00415-022-11256-y
pmc: PMC9618526
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6366-6376

Informations de copyright

© 2022. The Author(s).

Références

Eur J Paediatr Neurol. 2020 Nov;29:2-13
pubmed: 33162302
Brain. 2020 Sep 1;143(9):2733-2741
pubmed: 32810215
Semin Pediatr Neurol. 2017 May;24(2):122-128
pubmed: 28941527
Am J Ophthalmol. 2013 Feb;155(2):354-360.e1
pubmed: 23127751
Mult Scler. 2015 Feb;21(2):163-70
pubmed: 24948688
Int J Ophthalmol. 2018 Oct 18;11(10):1649-1656
pubmed: 30364209
Mult Scler. 2015 Dec;21(14):1781-93
pubmed: 25828758
Ann Neurol. 2015 Jan;77(1):183
pubmed: 25048078
J Neurol Sci. 2019 May 15;400:83-89
pubmed: 30904690
Mult Scler Relat Disord. 2013 May 1;3(3):326-334
pubmed: 24683535
Mult Scler J Exp Transl Clin. 2018 Jul 17;4(3):2055217318787829
pubmed: 30038790
J Neurol. 2021 Jan;268(1):276-284
pubmed: 32785840
Ann Neurol. 2021 Jan;89(1):30-41
pubmed: 32959427
Neurol Neuroimmunol Neuroinflamm. 2020 Jan 22;7(2):
pubmed: 32224498
Neurol Neuroimmunol Neuroinflamm. 2017 Jun 05;4(4):e356
pubmed: 28626779
Lancet Neurol. 2018 Feb;17(2):162-173
pubmed: 29275977
Br J Ophthalmol. 2019 Jun;103(6):831-836
pubmed: 30049802
Mult Scler. 2020 Dec;26(14):1854-1865
pubmed: 31937191
Front Neurol. 2017 Dec 22;8:710
pubmed: 29312131
Neurol Neuroimmunol Neuroinflamm. 2021 Oct 28;9(1):
pubmed: 34711644
J Neurol. 2017 Jan;264(1):139-151
pubmed: 27844165
Graefes Arch Clin Exp Ophthalmol. 2020 Jul;258(7):1523-1526
pubmed: 32274587
J Neuroinflammation. 2021 May 29;18(1):121
pubmed: 34051804
Mult Scler. 2015 May;21(6):678-88
pubmed: 25662342
Ther Adv Chronic Dis. 2019 Dec 2;10:2040622319882205
pubmed: 31832125
Eur J Paediatr Neurol. 2020 Jul;27:86-93
pubmed: 32327391
JAMA Neurol. 2021 Jun 1;78(6):741-746
pubmed: 33900394
Mult Scler J Exp Transl Clin. 2021 Dec 21;7(4):20552173211063126
pubmed: 35035987
Arch Neurol. 2012 Jun;69(6):752-6
pubmed: 22371853
Doc Ophthalmol. 2016 Aug;133(1):1-9
pubmed: 27443562
Ann Neurol. 2018 Aug;84(2):315-328
pubmed: 30014603
J Neuroinflammation. 2018 May 3;15(1):134
pubmed: 29724224
Ophthalmology. 2006 Feb;113(2):324-32
pubmed: 16406539
Eur J Paediatr Neurol. 2020 Nov;29:32-40
pubmed: 33183945
Neurology. 2016 Jun 14;86(24):2303-9
pubmed: 27225223
Front Neurol. 2020 Oct 08;11:540156
pubmed: 33132999
J Neuroinflammation. 2019 Jul 25;16(1):154
pubmed: 31345223
Neurology. 2021 Jul 6;97(1):e1-e12
pubmed: 33980704

Auteurs

T Pakeerathan (T)

Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44791, Bochum, Germany.

J Havla (J)

Institute of Clinical Neuroimmunology, LMU Hospital, Ludwig-Maximilians Universität München, Munich, Germany.
Data Integration for Future Medicine (DIFUTURE) Consortium, LMU Hospital, Ludwig-Maximilians Universität München, Munich, Germany.

C Schwake (C)

Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44791, Bochum, Germany.

A Salmen (A)

Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

S Bigi (S)

Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Division of Child Neurology, Department of Pediatrics, University Children's Hospital Bern, University of Bern, Bern, Switzerland.

M Abegg (M)

Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

D Brügger (D)

Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

T Ferrazzini (T)

Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

A-K Runge (AK)

Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

M Breu (M)

Division of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

B Kornek (B)

Department of Neurology, Medical University of Vienna, Vienna, Austria.

G Bsteh (G)

Department of Neurology, Medical University of Vienna, Vienna, Austria.

A Felipe-Rucián (A)

Department of Pediatric Neurology, Universitat Autònoma de Barcelona, Vall d'Hebron Hospital, Barcelona, Spain.

M Ringelstein (M)

Department of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Department of Neurology, Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

O Aktas (O)

Department of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

M Karenfort (M)

Department of General Paediatrics, Neonatology and Paediatric Cardiology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

E Wendel (E)

Department of Pediatric Neurology, Olgahospital, Stuttgart, Germany.

I Kleiter (I)

Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44791, Bochum, Germany.
Marianne-Strauß-Klinik, Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg, Germany.

K Hellwig (K)

Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44791, Bochum, Germany.

T Kümpfel (T)

Institute of Clinical Neuroimmunology, LMU Hospital, Ludwig-Maximilians Universität München, Munich, Germany.

C Thiels (C)

Department of Neuropediatrics, University Children's Hospital, Ruhr-University, Bochum, Germany.

T Lücke (T)

Department of Neuropediatrics, University Children's Hospital, Ruhr-University, Bochum, Germany.

R Gold (R)

Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44791, Bochum, Germany.

K Rostasy (K)

Department of Pediatric Neurology, Children's Hospital Datteln, University Witten/Herdecke, Witten, Germany.

I Ayzenberg (I)

Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44791, Bochum, Germany. ilya.ayzenberg@rub.de.
ORCID: 0000-0002-6009-792X

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Classifications MeSH

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questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Characteristic retinal atrophy pattern allows...
questionsmedicales.fr › Maladies de l'oeil › Atteintes du nerf optique › Névrite optique › Characteristic retinal atrophy pattern allows...
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