Saccadic contributions to smooth pursuit in macular degeneration.
Central field loss
Macular degeneration
Saccades
Smooth pursuit
Journal
Vision research
ISSN: 1878-5646
Titre abrégé: Vision Res
Pays: England
ID NLM: 0417402
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
13
12
2021
revised:
12
04
2022
accepted:
27
06
2022
pubmed:
24
7
2022
medline:
14
10
2022
entrez:
23
7
2022
Statut:
ppublish
Résumé
Saccades during smooth pursuit can help bring the fovea on target, particularly in cases of low pursuit gain. Individuals with macular degeneration often suffer damage to the central retina including the fovea, which impacts oculomotor function such as fixation, saccadic and smooth pursuit eye movements. We hypothesized that these oculomotor changes in macular degeneration (MD) would make saccades less appropriately directed (even if more numerous). To investigate saccades during pursuit in MD, we conducted a quantitative analysis of smooth pursuit eye movement data from a prior study, Vision Research 141 (2017) 181-190. Here we examined saccade frequency, magnitude, and direction across viewing conditions for MD and control participants during pursuit of a target moving in a modified step-ramp paradigm. Individuals with MD had more variability in saccade directions that included directions orthogonal to the target trajectory. PRL eccentricity significantly correlated with increases in saccades in non-target directions during smooth pursuit. These results suggest that a large number of saccades during pursuit in MD participants are unlikely to be catch-up saccades that serve to keep the eye on the target.
Identifiants
pubmed: 35870286
pii: S0042-6989(22)00108-0
doi: 10.1016/j.visres.2022.108102
pmc: PMC9831682
mid: NIHMS1860526
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
108102Subventions
Organisme : NEI NIH HHS
ID : R01 EY027390
Pays : United States
Organisme : NEI NIH HHS
ID : K99 EY026994
Pays : United States
Organisme : NEI NIH HHS
ID : F32 EY025151
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY022394
Pays : United States
Organisme : NEI NIH HHS
ID : R00 EY026994
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
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