Revisiting the concept of childhood preleukemia.

Child Humans Preleukemia / genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics Mutation
childhood leukemia genetic predisposition mouse models preclinical prevention

Journal

Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956

Informations de publication

Date de publication:
11 2022
Historique:
received: 31 05 2022
revised: 28 06 2022
accepted: 30 06 2022
pubmed: 24 7 2022
medline: 22 10 2022
entrez: 23 7 2022
Statut: ppublish

Résumé

Preleukemic has been used to describe children with a propensity to develop B cell acute lymphoblastic leukemia (B-ALL). However, leukemia-predisposing mutations can also be present in differentiated cells unable to transform. We postulate that preleukemia should only be used when such mutations arise in progenitors capable of evolving to B-ALL.

Identifiants

DOI: 10.1016/j.trecan.2022.06.012 PMID: 35871053
pubmed: 35871053
pii: S2405-8033(22)00152-2
doi: 10.1016/j.trecan.2022.06.012
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

887-889

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests No interests are declared.

Auteurs

Cesar Cobaleda (C)

Immune system development and function Unit, Centro de Biología Molecular Severo Ochoa (CSIC -Universidad Autónoma de Madrid), Madrid, Spain. Electronic address: cesar.cobaleda@csic.es.

Carolina Vicente-Dueñas (C)

Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.

Manuel Ramírez-Orellana (M)

Department of Pediatric Hematology and Oncology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Madrid, Spain. Electronic address: manuel.ramirez@salud.madrid.org.

Isidro Sanchez-Garcia (I)

Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca, Salamanca, Spain. Electronic address: isg@usal.es.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Revisiting the concept of childhood preleukemia.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Revisiting the concept of childhood preleukemia.
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Préleucémie › Revisiting the concept of childhood preleukemia.
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Leucémie lymphoïde › Leucémie-lymphome lymphoblastique à précurseurs B et T › Revisiting the concept of childhood preleukemia.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Revisiting the concept of childhood preleukemia.