Persistent blood DNA methylation changes one year after SARS-CoV-2 infection.
COVID-19
DNA methylation
PASC
SARS
Journal
Clinical epigenetics
ISSN: 1868-7083
Titre abrégé: Clin Epigenetics
Pays: Germany
ID NLM: 101516977
Informations de publication
Date de publication:
23 07 2022
23 07 2022
Historique:
received:
05
04
2022
accepted:
11
07
2022
entrez:
23
7
2022
pubmed:
24
7
2022
medline:
27
7
2022
Statut:
epublish
Résumé
We recently reported the COVID-19-induced circulating leukocytes DNA methylation profile. Here, we hypothesized that some of these genes would persist differentially methylated after disease resolution. Fifteen participants previously hospitalized for SARS-CoV-2 infection were epityped one year after discharge. Of the 1505 acute illness-induced differentially methylated regions (DMRs) previously identified, we found 71 regions with persisted differentially methylated, with an average of 7 serial CpG positions per DMR. Sixty-four DMRs persisted hypermethylated, and 7 DMR persisted hypomethylated. These data are the first reported evidence that DNA methylation changes in circulating leukocytes endure long after recovery from acute illness.
Identifiants
pubmed: 35871090
doi: 10.1186/s13148-022-01313-8
pii: 10.1186/s13148-022-01313-8
pmc: PMC9308917
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
94Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL160661
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG066179
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL049426
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL130704
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG077633
Pays : United States
Informations de copyright
© 2022. The Author(s).
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