Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: a randomised crossover trial.
Circadian rhythm
Glucose homeostasis
Hepatic fat
Hepatic glycogen
Insulin sensitivity
Intermittent fasting
Lifestyle intervention
Mitochondrial oxidative capacity
TRE
Type 2 diabetes
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
24
02
2022
accepted:
23
05
2022
pubmed:
25
7
2022
medline:
20
9
2022
entrez:
24
7
2022
Statut:
ppublish
Résumé
Time-restricted eating (TRE) is suggested to improve metabolic health by limiting food intake to a defined time window, thereby prolonging the overnight fast. This prolonged fast is expected to lead to a more pronounced depletion of hepatic glycogen stores overnight and might improve insulin sensitivity due to an increased need to replenish nutrient storage. Previous studies showed beneficial metabolic effects of 6-8 h TRE regimens in healthy, overweight adults under controlled conditions. However, the effects of TRE on glucose homeostasis in individuals with type 2 diabetes are unclear. Here, we extensively investigated the effects of TRE on hepatic glycogen levels and insulin sensitivity in individuals with type 2 diabetes. Fourteen adults with type 2 diabetes (BMI 30.5±4.2 kg/m Results are depicted as mean ± SEM. Hepatic glycogen content was similar between TRE and control condition (0.15±0.01 vs 0.15±0.01 AU, p=0.88). M value was not significantly affected by TRE (19.6±1.8 vs 17.7±1.8 μmol kg We show that a 10 h TRE regimen is a feasible, safe and effective means to improve 24 h glucose homeostasis in free-living adults with type 2 diabetes. However, these changes were not accompanied by changes in insulin sensitivity or hepatic glycogen. ClinicalTrials.gov NCT03992248 FUNDING: ZonMW, 459001013.
Identifiants
pubmed: 35871650
doi: 10.1007/s00125-022-05752-z
pii: 10.1007/s00125-022-05752-z
pmc: PMC9477920
doi:
Substances chimiques
Blood Glucose
0
Insulin
0
Lipids
0
Liver Glycogen
0
Glucose
IY9XDZ35W2
Banques de données
ClinicalTrials.gov
['NCT03992248']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1710-1720Informations de copyright
© 2022. The Author(s).
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