Effect of Cytomegalovirus on the Immune System: Implications for Aging and Mental Health.
Aging
Cytomegalovirus
Immunity
Immunosenescence
Inflammation
Psychiatric disorders
Stress
Vaccine
Journal
Current topics in behavioral neurosciences
ISSN: 1866-3370
Titre abrégé: Curr Top Behav Neurosci
Pays: Germany
ID NLM: 101535383
Informations de publication
Date de publication:
2023
2023
Historique:
pubmed:
25
7
2022
medline:
25
2
2023
entrez:
24
7
2022
Statut:
ppublish
Résumé
Human cytomegalovirus (HCMV) is a major modulator of the immune system leading to long-term changes in T-lymphocytes, macrophages, and natural killer (NK) cells among others. Perhaps because of this immunomodulatory capacity, HCMV infection has been linked with a host of deleterious effects including accelerated immune aging (premature mortality, increased expression of immunosenescence-linked markers, telomere shortening, speeding-up of epigenetic "clocks"), decreased vaccine immunogenicity, and greater vulnerability to infectious diseases (e.g., tuberculosis) or infectious disease-associated pathology (e.g., HIV). Perhaps not surprisingly given the long co-evolution between HCMV and humans, the virus has also been associated with beneficial effects, such as increased vaccine responsiveness, heterologous protection against infections, and protection against relapse in the context of leukemia. Here, we provide an overview of this literature. Ultimately, we focus on one other deleterious effect of HCMV, namely the emerging literature suggesting that HCMV plays a pathophysiological role in psychiatric illness, particularly depression and schizophrenia. We discuss this literature through the lens of psychological stress and inflammation, two well-established risk factors for psychiatric illness that are also known to predispose to reactivation of HCMV.
Identifiants
pubmed: 35871707
doi: 10.1007/7854_2022_376
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
181-214Informations de copyright
© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.
Références
Abate DA, Watanabe S, Mocarski ES (2004) Major human cytomegalovirus structural protein pp65 (ppUL83) prevents interferon response factor 3 activation in the interferon response. J Virol 78:10995–11006
pubmed: 15452220
pmcid: 521853
doi: 10.1128/JVI.78.20.10995-11006.2004
Abdoli A, Falahi S, Kenarkoohi A (2021) COVID-19-associated opportunistic infections: a snapshot on the current reports. Clin Exp Med. https://doi.org/10.1007/s10238-021-00751-7
Adler SP (1985) The molecular epidemiology of cytomegalovirus transmission among children attending a day care center. J Infect Dis 152:760–768
pubmed: 2995502
doi: 10.1093/infdis/152.4.760
Ahn K, Angulo A, Ghazal P et al (1996) Human cytomegalovirus inhibits antigen presentation by a sequential multistep process. Proc Natl Acad Sci U S A 93:10990–10995
pubmed: 8855296
pmcid: 38271
doi: 10.1073/pnas.93.20.10990
Ahn K, Gruhler A, Galocha B et al (1997) The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. Immunity 6:613–621
pubmed: 9175839
doi: 10.1016/S1074-7613(00)80349-0
Aiello AE, Jayabalasingham B, Simanek AM et al (2017) The impact of pathogen burden on leukocyte telomere length in the Multi-Ethnic Study of Atherosclerosis. Epidemiol Infect 145:3076–3084
pubmed: 28879822
pmcid: 9152739
doi: 10.1017/S0950268817001881
Alain S, Garnier-Geoffroy F, Labrunie A et al (2020) Cytomegalovirus (CMV) shedding in French day-care centers: a nationwide study of epidemiology, risk factors, centers’ practices, and parents’ awareness of CMV. J Pediatric Infect Dis Soc 9:686–694
pubmed: 32068854
doi: 10.1093/jpids/piz097
Alanio C, Verma A, Mathew D et al (2022) Cytomegalovirus latent infection is associated with an increased risk of COVID-19-related hospitalization. J Infect Dis. https://doi.org/10.1093/infdis/jiac020
Albrecht P, Boone E, Fuller Torrey E et al (1980) Raised cytomegalovirus-antibody level in cerebrospinal fluid of schizophrenic patients. Lancet 316:769–772
doi: 10.1016/S0140-6736(80)90386-4
Alcendor DJ, Charest AM, Zhu WQ et al (2012) Infection and upregulation of proinflammatory cytokines in human brain vascular pericytes by human cytomegalovirus. J Neuroinflammation 9:95
pubmed: 22607552
pmcid: 3413582
doi: 10.1186/1742-2094-9-95
Almanzar G, Schwaiger S, Jenewein B et al (2005) Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons. J Virol 79:3675–3683
pubmed: 15731261
pmcid: 1075718
doi: 10.1128/JVI.79.6.3675-3683.2005
Amiya S, Hirata H, Shiroyama T et al (2021) Fatal cytomegalovirus pneumonia in a critically ill patient with COVID-19. Respirol Case Rep 9:e00801
pubmed: 34136262
pmcid: 8185623
doi: 10.1002/rcr2.801
Amundson L, Boelts B, Kataria V, Spak C (2021) Ganciclovir therapy for CMV viremia in a patient on VV ECMO with COVID-19 after treatment with tocilizumab. Infect Dis Clin Pract (Baltim Md) 29:e191–e192
doi: 10.1097/IPC.0000000000001035
Anders DG, Kerry JA, Pari GS (2011) DNA synthesis and late viral gene expression. In: Arvin A, Campadelli-Fiume G, Mocarski E et al (eds) Human herpesviruses: biology, therapy, and immunoprophylaxis. Cambridge University Press, Cambridge
Andreou D, Jørgensen KN, Nerland S et al (2021) Cytomegalovirus infection associated with smaller dentate gyrus in men with severe mental illness. Brain Behav Immun 96:54–62
pubmed: 34010712
doi: 10.1016/j.bbi.2021.05.009
Appay V, Dunbar PR, Callan M et al (2002) Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med 8:379–385
pubmed: 11927944
doi: 10.1038/nm0402-379
Appels A, Bär FW, Bär J et al (2000) Inflammation, depressive symptomtology, and coronary artery disease. Psychosom Med 62:601–605
pubmed: 11020087
doi: 10.1097/00006842-200009000-00001
Aubert G, Lansdorp PM (2008) Telomeres and aging. Physiol Rev 88:557–579
pubmed: 18391173
doi: 10.1152/physrev.00026.2007
Avramopoulos D, Pearce BD, McGrath J et al (2015) Infection and inflammation in schizophrenia and bipolar disorder: a genome wide study for interactions with genetic variation. PLoS One 10:e0116696
pubmed: 25781172
pmcid: 4363491
doi: 10.1371/journal.pone.0116696
Bacalini MG, Deelen J, Pirazzini C et al (2017) Systemic age-associated DNA hypermethylation of ELOVL2 gene: In vivo and in vitro evidences of a cell replication process. J Gerontol A Biol Sci Med Sci 72:1015–1023
pubmed: 27672102
doi: 10.1093/gerona/glw185
Barbalat R, Lau L, Locksley RM, Barton GM (2009) Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat Immunol 10:1200–1207
pubmed: 19801985
pmcid: 2821672
doi: 10.1038/ni.1792
Bate SL, Dollard SC, Cannon MJ (2010) Cytomegalovirus seroprevalence in the United States: the national health and nutrition examination surveys, 1988-2004. Clin Infect Dis 50:1439–1447
pubmed: 20426575
doi: 10.1086/652438
Beards S, Fisher HL, Gayer-Anderson C et al (2020) Threatening life events and difficulties and psychotic disorder. Schizophr Bull 46:814–822
pubmed: 32047940
pmcid: 7342097
doi: 10.1093/schbul/sbaa005
Behrendt CE, Rosenthal J, Bolotin E et al (2009) Donor and recipient CMV serostatus and outcome of pediatric allogeneic HSCT for acute leukemia in the era of CMV-preemptive therapy. Biol Blood Marrow Transplant 15:54–60
pubmed: 19135943
pmcid: 2803021
doi: 10.1016/j.bbmt.2008.10.023
Bennett JM, Glaser R, Malarkey WB et al (2012) Inflammation and reactivation of latent herpesviruses in older adults. Brain Behav Immun 26:739–746
pubmed: 22155500
doi: 10.1016/j.bbi.2011.11.007
Bentz GL, Jarquin-Pardo M, Chan G et al (2006) Human cytomegalovirus (HCMV) infection of endothelial cells promotes naive monocyte extravasation and transfer of productive virus to enhance hematogenous dissemination of HCMV. J Virol 80:11539–11555
pubmed: 16987970
pmcid: 1642592
doi: 10.1128/JVI.01016-06
Béziat V, Rapaport F, Hu J et al (2021) Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy. Cell 184:3812–3828.e30
pubmed: 34214472
pmcid: 8329841
doi: 10.1016/j.cell.2021.06.004
Biolatti M, Dell’Oste V, De Andrea M, Landolfo S (2018a) The human cytomegalovirus tegument protein pp65 (pUL83): a key player in innate immune evasion. New Microbiol 41:87–94
pubmed: 29384558
Biolatti M, Dell’Oste V, Pautasso S et al (2018b) Human cytomegalovirus tegument protein pp65 (pUL83) Dampens type I interferon production by inactivating the DNA sensor cGAS without affecting STING. J Virol 92. https://doi.org/10.1128/JVI.01774-17
Boehme KW, Singh J, Perry ST, Compton T (2004) Human cytomegalovirus elicits a coordinated cellular antiviral response via envelope glycoprotein B. J Virol 78:1202–1211
pubmed: 14722275
pmcid: 321386
doi: 10.1128/JVI.78.3.1202-1211.2004
Boehme KW, Guerrero M, Compton T (2006) Human cytomegalovirus envelope glycoproteins B and H are necessary for TLR2 activation in permissive cells. J Immunol 177:7094–7102
pubmed: 17082626
doi: 10.4049/jimmunol.177.10.7094
Bosch JA, Fischer JE, Fischer JC (2009) Psychologically adverse work conditions are associated with CD8+ T cell differentiation indicative of immunesenescence. Brain Behav Immun 23:527–534
pubmed: 19217939
doi: 10.1016/j.bbi.2009.02.002
Bowyer G, Sharpe H, Venkatraman N et al (2020) Reduced Ebola vaccine responses in CMV+ young adults is associated with expansion of CD57+KLRG1+ T cells. J Exp Med 217. https://doi.org/10.1084/jem.20200004
Boyle KA, Pietropaolo RL, Compton T (1999) Engagement of the cellular receptor for glycoprotein B of human cytomegalovirus activates the interferon-responsive pathway. Mol Cell Biol 19:3607–3613
pubmed: 10207084
pmcid: 84158
doi: 10.1128/MCB.19.5.3607
Boyle CC, Cole SW, Dutcher JM et al (2019) Changes in eudaimonic well-being and the conserved transcriptional response to adversity in younger breast cancer survivors. Psychoneuroendocrinology 103:173–179
pubmed: 30703712
doi: 10.1016/j.psyneuen.2019.01.024
Brander G, Pérez-Vigil A, Larsson H, Mataix-Cols D (2016) Systematic review of environmental risk factors for obsessive-compulsive disorder: a proposed roadmap from association to causation. Neurosci Biobehav Rev 65:36–62
pubmed: 27013116
doi: 10.1016/j.neubiorev.2016.03.011
Brodin P, Jojic V, Gao T et al (2015) Variation in the human immune system is largely driven by non-heritable influences. Cell 160:37–47
pubmed: 25594173
pmcid: 4302727
doi: 10.1016/j.cell.2014.12.020
Browne EP, Shenk T (2003) Human cytomegalovirus UL83-coded pp65 virion protein inhibits antiviral gene expression in infected cells. Proc Natl Acad Sci U S A 100:11439–11444
pubmed: 12972646
pmcid: 208776
doi: 10.1073/pnas.1534570100
Browne EP, Wing B, Coleman D, Shenk T (2001) Altered cellular mRNA levels in human cytomegalovirus-infected fibroblasts: viral block to the accumulation of antiviral mRNAs. J Virol 75:12319–12330
pubmed: 11711622
pmcid: 116128
doi: 10.1128/JVI.75.24.12319-12330.2001
Cannon MJ, Schmid DS, Hyde TB (2010) Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Rev Med Virol 20:202–213
pubmed: 20564615
doi: 10.1002/rmv.655
Cannon MJ, Hyde TB, Schmid DS (2011) Review of cytomegalovirus shedding in bodily fluids and relevance to congenital cytomegalovirus infection. Rev Med Virol 21:240–255
pubmed: 21674676
pmcid: 4494736
doi: 10.1002/rmv.695
Celada A, McKercher S, Maki RA (1993) Repression of major histocompatibility complex IA expression by glucocorticoids: the glucocorticoid receptor inhibits the DNA binding of the X box DNA binding protein. J Exp Med 177:691–698
pubmed: 8436907
doi: 10.1084/jem.177.3.691
Chan G, Bivins-Smith ER, Smith MS et al (2008) Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophage. J Immunol 181:698–711
pubmed: 18566437
doi: 10.4049/jimmunol.181.1.698
Chang WLW, Barry PA (2010) Attenuation of innate immunity by cytomegalovirus IL-10 establishes a long-term deficit of adaptive antiviral immunity. Proc Natl Acad Sci U S A 107:22647–22652
pubmed: 21149711
pmcid: 3012498
doi: 10.1073/pnas.1013794108
Chang WLW, Barry PA, Szubin R et al (2009) Human cytomegalovirus suppresses type I interferon secretion by plasmacytoid dendritic cells through its interleukin 10 homolog. Virology 390:330–337
pubmed: 19524994
doi: 10.1016/j.virol.2009.05.013
Chen B, Morris SR, Panigrahi S et al (2020) Cytomegalovirus coinfection is associated with increased vascular-homing CD57+ CD4 T cells in HIV infection. J Immunol 204:2722–2733
pubmed: 32229536
doi: 10.4049/jimmunol.1900734
Chen S, Pawelec G, Trompet S et al (2021) Associations of cytomegalovirus infection with all-cause and cardiovascular mortality in multiple observational cohort studies of older adults. J Infect Dis 223:238–246
pubmed: 32909605
doi: 10.1093/infdis/jiaa480
Choi HJ, Park A, Kang S et al (2018) Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses. Nat Commun 9:125
pubmed: 29317664
pmcid: 5760629
doi: 10.1038/s41467-017-02624-8
Cohen S, Williamson GM (1991) Stress and infectious disease in humans. Psychol Bull 109:5–24
pubmed: 2006229
doi: 10.1037/0033-2909.109.1.5
Cohen S, Tyrrell DA, Smith AP (1991) Psychological stress and susceptibility to the common cold. N Engl J Med 325:606–612
pubmed: 1713648
doi: 10.1056/NEJM199108293250903
Cohen S, Janicki-Deverts D, Doyle WJ et al (2012) Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci U S A 109:5995–5999
pubmed: 22474371
pmcid: 3341031
doi: 10.1073/pnas.1118355109
Cole SW (2019) The conserved transcriptional response to adversity. Curr Opin Behav Sci 28:31–37
pubmed: 31592179
pmcid: 6779418
doi: 10.1016/j.cobeha.2019.01.008
Cole SW, Levine ME, Arevalo JMG et al (2015) Loneliness, eudaimonia, and the human conserved transcriptional response to adversity. Psychoneuroendocrinology 62:11–17
pubmed: 26246388
pmcid: 4637182
doi: 10.1016/j.psyneuen.2015.07.001
Collins-McMillen D, Buehler J, Peppenelli M, Goodrum F (2018) Molecular determinants and the regulation of human cytomegalovirus latency and reactivation. Viruses 10. https://doi.org/10.3390/v10080444
Collins-McMillen D, Kamil J, Moorman N, Goodrum F (2020) Control of immediate early gene expression for human cytomegalovirus reactivation. Front Cell Infect Microbiol 10:476
pubmed: 33072616
pmcid: 7533536
doi: 10.3389/fcimb.2020.00476
Compton T, Nowlin DM, Cooper NR (1993) Initiation of human cytomegalovirus infection requires initial interaction with cell surface heparan sulfate. Virology 193:834–841
pubmed: 8384757
doi: 10.1006/viro.1993.1192
Compton T, Kurt-Jones EA, Boehme KW et al (2003) Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J Virol 77:4588–4596
pubmed: 12663765
pmcid: 152130
doi: 10.1128/JVI.77.8.4588-4596.2003
Coryell W, Wilcox H, Evans SJ et al (2020) Latent infection, inflammatory markers and suicide attempt history in depressive disorders. J Affect Disord 270:97–101
pubmed: 32339111
doi: 10.1016/j.jad.2020.03.057
Crough T, Khanna R (2009) Immunobiology of human cytomegalovirus: from bench to bedside. Clin Microbiol Rev 22:76–98. Table of Contents
pubmed: 19136435
pmcid: 2620639
doi: 10.1128/CMR.00034-08
Dalman C, Allebeck P, Gunnell D et al (2008) Infections in the CNS during childhood and the risk of subsequent psychotic illness: a cohort study of more than one million Swedish subjects. Am J Psychiatry 165:59–65
pubmed: 18056223
doi: 10.1176/appi.ajp.2007.07050740
Day R (1981) Life events and schizophrenia: the “triggering” hypothesis. Acta Psychiatr Scand 64:97–122
pubmed: 7032227
doi: 10.1111/j.1600-0447.1981.tb00765.x
de Bourcy CFA, Angel CJL, Vollmers C et al (2017) Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging. Proc Natl Acad Sci U S A 114:1105–1110
pubmed: 28096374
pmcid: 5293037
doi: 10.1073/pnas.1617959114
Deayton JR, Prof Sabin CA, Johnson MA et al (2004) Importance of cytomegalovirus viraemia in risk of disease progression and death in HIV-infected patients receiving highly active antiretroviral therapy. Lancet 363:2116–2121
pubmed: 15220032
doi: 10.1016/S0140-6736(04)16500-8
Dell’Oste V, Biolatti M, Galitska G et al (2020) Tuning the orchestra: HCMV vs. innate immunity. Front Microbiol 11:661
pubmed: 32351486
pmcid: 7174589
doi: 10.3389/fmicb.2020.00661
Detels R, Leach CT, Hennessey K et al (1994) Persistent cytomegalovirus infection of semen increases risk of AIDS. J Infect Dis 169:766–768
pubmed: 8133089
doi: 10.1093/infdis/169.4.766
Dickerson F, Wilcox HC, Adamos M et al (2017) Suicide attempts and markers of immune response in individuals with serious mental illness. J Psychiatr Res 87:37–43
pubmed: 27988332
doi: 10.1016/j.jpsychires.2016.11.011
Dickerson F, Origoni A, Schweinfurth LAB et al (2018) Clinical and serological predictors of suicide in schizophrenia and major mood disorders. J Nerv Ment Dis 206:173–178
pubmed: 29474231
doi: 10.1097/NMD.0000000000000772
Döcke WD, Prösch S, Fietze E et al (1994) Cytomegalovirus reactivation and tumour necrosis factor. Lancet 343:268–269
pubmed: 7905100
doi: 10.1016/S0140-6736(94)91116-9
Dowd JB, Aiello AE, Alley DE (2009) Socioeconomic disparities in the seroprevalence of cytomegalovirus infection in the US population: NHANES III. Epidemiol Infect 137:58–65
pubmed: 18413004
doi: 10.1017/S0950268808000551
Dowd JB, Palermo TM, Aiello AE (2012) Family poverty is associated with cytomegalovirus antibody titers in U.S. children. Health Psychol 31:5–10
pubmed: 21895372
doi: 10.1037/a0025337
Dowd JB, Bosch JA, Steptoe A et al (2017) Persistent herpesvirus infections and telomere attrition over 3 years in the Whitehall II cohort. J Infect Dis 216:565–572
pubmed: 28931225
pmcid: 5853283
doi: 10.1093/infdis/jix255
Effros RB (2004) From Hayflick to Walford: the role of T cell replicative senescence in human aging. Exp Gerontol 39:885–890
pubmed: 15217682
doi: 10.1016/j.exger.2004.03.004
Elmaagacli AH, Steckel NK, Koldehoff M et al (2011) Early human cytomegalovirus replication after transplantation is associated with a decreased relapse risk: evidence for a putative virus-versus-leukemia effect in acute myeloid leukemia patients. Blood 118:1402–1412
pubmed: 21540462
doi: 10.1182/blood-2010-08-304121
Elste J, Kaltenbach D, Patel VR et al (2020) Inhibition of human cytomegalovirus entry into host cells through a pleiotropic small molecule. Int J Mol Sci 21. https://doi.org/10.3390/ijms21051676
Estrada LD, Ağaç D, Farrar JD (2016) Sympathetic neural signaling via the β2-adrenergic receptor suppresses T-cell receptor-mediated human and mouse CD8(+) T-cell effector function. Eur J Immunol 46:1948–1958
pubmed: 27222010
pmcid: 5241047
doi: 10.1002/eji.201646395
Fagundes CP, Glaser R, Malarkey WB, Kiecolt-Glaser JK (2013) Childhood adversity and herpesvirus latency in breast cancer survivors. Health Psychol 32:337–344
pubmed: 22746260
doi: 10.1037/a0028595
Farrell HE, Stevenson PG (2019) Cytomegalovirus host entry and spread. J Gen Virol 100:545–553
pubmed: 30730289
doi: 10.1099/jgv.0.001230
Feng L, Sheng J, Vu G-P et al (2018) Human cytomegalovirus UL23 inhibits transcription of interferon-γ stimulated genes and blocks antiviral interferon-γ responses by interacting with human N-myc interactor protein. PLoS Pathog 14:e1006867
pubmed: 29377960
pmcid: 5805366
doi: 10.1371/journal.ppat.1006867
Ferguson FG, Wikby A, Maxson P et al (1995) Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors. J Gerontol A Biol Sci Med Sci 50:B378–B382
pubmed: 7583794
doi: 10.1093/gerona/50A.6.B378
Ford BN, Yolken RH, Aupperle RL et al (2019) Association of early-life stress with cytomegalovirus infection in adults with major depressive disorder. JAMA Psychiat 76:545–547
doi: 10.1001/jamapsychiatry.2018.4543
Ford BN, Teague TK, Bayouth M et al (2020) Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection. Brain Behav Immun 87:795–803
pubmed: 32209361
pmcid: 7594105
doi: 10.1016/j.bbi.2020.03.013
Fowler KB, Pass RF (2006) Risk factors for congenital cytomegalovirus infection in the offspring of young women: exposure to young children and recent onset of sexual activity. Pediatrics 118:e286–e292
pubmed: 16847076
doi: 10.1542/peds.2005-1142
Foxworth MK 2nd, Wilms IR, Brookman RR et al (2014) Prevalence of CMV infection among sexually active adolescents: a matched case-control study. Adolesc Health Med Ther 5:73–78
pubmed: 24808724
pmcid: 4010613
Frye MA, Coombes BJ, McElroy SL et al (2019) Association of cytomegalovirus and Toxoplasma gondii antibody titers with bipolar disorder. JAMA Psychiat. https://doi.org/10.1001/jamapsychiatry.2019.2499
Fu Y-Z, Su S, Gao Y-Q et al (2017) Human cytomegalovirus tegument protein UL82 inhibits STING-mediated signaling to evade antiviral immunity. Cell Host Microbe 21:231–243
pubmed: 28132838
doi: 10.1016/j.chom.2017.01.001
Fu Y-Z, Su S, Zou H-M et al (2019) Human cytomegalovirus DNA polymerase subunit UL44 antagonizes antiviral immune responses by suppressing IRF3- and NF-κB-mediated transcription. J Virol 93. https://doi.org/10.1128/JVI.00181-19
Furman D, Jojic V, Sharma S et al (2015) Cytomegalovirus infection enhances the immune response to influenza. Sci Transl Med 7:281ra43
pubmed: 25834109
pmcid: 4505610
doi: 10.1126/scitranslmed.aaa2293
Fusar-Poli P, Tantardini M, De Simone S et al (2017) Deconstructing vulnerability for psychosis: meta-analysis of environmental risk factors for psychosis in subjects at ultra high-risk. Eur Psychiatry 40:65–75
pubmed: 27992836
doi: 10.1016/j.eurpsy.2016.09.003
Gale SD, Berrett AN, Erickson LD et al (2018) Association between virus exposure and depression in US adults. Psychiatry Res 261:73–79
pubmed: 29287239
doi: 10.1016/j.psychres.2017.12.037
Gariano GR, Dell’Oste V, Bronzini M et al (2012) The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication. PLoS Pathog 8:e1002498
pubmed: 22291595
pmcid: 3266931
doi: 10.1371/journal.ppat.1002498
Garson D, Dokhélar MC, Wakasugi H et al (1985) HLA class-I and class-II antigen expression by human leukemic K562 cells and by Burkitt-K562 hybrids: modulation by differentiation inducers and interferon. Exp Hematol 13:885–890
pubmed: 3930277
Gerna G, Kabanova A, Lilleri D (2019) Human cytomegalovirus cell tropism and host cell receptors. Vaccines (Basel) 7. https://doi.org/10.3390/vaccines7030070
Gianella S, Letendre S (2016) Cytomegalovirus and HIV: a dangerous Pas de Deux. J Infect Dis 214(Suppl 2):S67–S74
pubmed: 27625433
pmcid: 5021239
doi: 10.1093/infdis/jiw217
Gkrania-Klotsas E, Langenberg C, Sharp SJ et al (2013) Seropositivity and higher immunoglobulin g antibody levels against cytomegalovirus are associated with mortality in the population-based European prospective investigation of cancer-Norfolk cohort. Clin Infect Dis 56:1421–1427
pubmed: 23442763
pmcid: 3634310
doi: 10.1093/cid/cit083
Glaser R, Kiecolt-Glaser JK (1994) Stress-associated immune modulation and its implications for reactivation of latent herpesviruses. Infect Dis Ther Ser 13:245–245
Goodrum F, Caviness K, Zagallo P (2012) Human cytomegalovirus persistence. Cell Microbiol 14:644–655
pubmed: 22329758
pmcid: 3330195
doi: 10.1111/j.1462-5822.2012.01774.x
Goodwin K, Viboud C, Simonsen L (2006) Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine 24:1159–1169
pubmed: 16213065
doi: 10.1016/j.vaccine.2005.08.105
Goudot C, Coillard A, Villani A-C et al (2017) Aryl hydrocarbon receptor controls monocyte differentiation into dendritic cells versus macrophages. Immunity 47:582–596.e6
pubmed: 28930664
doi: 10.1016/j.immuni.2017.08.016
Gozzi-Silva SC, Benard G, Alberca RW et al (2021) SARS-CoV-2 infection and CMV dissemination in transplant recipients as a treatment for Chagas cardiomyopathy: a case report. Trop Med Infect Dis 6:22
pubmed: 33579042
pmcid: 7985779
doi: 10.3390/tropicalmed6010022
Grattan MT (1989) Cytomegalovirus infection is associated with cardiac allograft rejection and atherosclerosis. JAMA 261:3561–3566
pubmed: 2542633
doi: 10.1001/jama.1989.03420240075030
Gredmark S, Britt WB, Xie X et al (2004) Human cytomegalovirus induces inhibition of macrophage differentiation by binding to human aminopeptidase N/CD13. J Immunol 173:4897–4907
pubmed: 15470031
doi: 10.4049/jimmunol.173.8.4897
Grosjean J, Trapes L, Hantz S et al (2014) Human cytomegalovirus quantification in toddlers saliva from day care centers and emergency unit: a feasibility study. J Clin Virol 61:371–377
pubmed: 25183358
doi: 10.1016/j.jcv.2014.07.020
Groves IJ, Jackson SE, Poole EL et al (2021) Bromodomain proteins regulate human cytomegalovirus latency and reactivation allowing epigenetic therapeutic intervention. Proc Natl Acad Sci U S A 118. https://doi.org/10.1073/pnas.2023025118
Gugliesi F, Coscia A, Griffante G et al (2020) Where do we stand after decades of studying human cytomegalovirus? Microorganisms 8:685
pubmed: 32397070
pmcid: 7284540
doi: 10.3390/microorganisms8050685
Guo G, Ye S, Xie S et al (2018) The cytomegalovirus protein US31 induces inflammation through mono-macrophages in systemic lupus erythematosus by promoting NF-κB2 activation. Cell Death Dis 9:104
pubmed: 29367719
pmcid: 5833803
doi: 10.1038/s41419-017-0122-4
Hammen C (2018) Risk factors for depression: an autobiographical review. Annu Rev Clin Psychol 14:1–28
pubmed: 29328780
doi: 10.1146/annurev-clinpsy-050817-084811
Handsfield HH, Chandler SH, Caine VA et al (1985) Cytomegalovirus infection in sex partners: evidence for sexual transmission. J Infect Dis 151:344–348
pubmed: 2981937
doi: 10.1093/infdis/151.2.344
Hargett D, Shenk TE (2010) Experimental human cytomegalovirus latency in CD14+ monocytes. Proc Natl Acad Sci U S A 107:20039–20044
pubmed: 21041645
pmcid: 2993366
doi: 10.1073/pnas.1014509107
Harvala H, Stewart C, Muller K et al (2013) High risk of cytomegalovirus infection following solid organ transplantation despite prophylactic therapy. J Med Virol 85:893–898
pubmed: 23508914
doi: 10.1002/jmv.23539
He C-S, Handzlik M, Muhamad A, Gleeson M (2013) Influence of CMV/EBV serostatus on respiratory infection incidence during 4 months of winter training in a student cohort of endurance athletes. Eur J Appl Physiol 113:2613–2619
pubmed: 23922172
doi: 10.1007/s00421-013-2704-x
Hegde NR, Tomazin RA, Wisner TW et al (2002) Inhibition of HLA-DR assembly, transport, and loading by human cytomegalovirus glycoprotein US3: a novel mechanism for evading major histocompatibility complex class II antigen presentation. J Virol 76:10929–10941
pubmed: 12368336
pmcid: 136637
doi: 10.1128/JVI.76.21.10929-10941.2002
Herndler-Brandstetter D, Landgraf K, Tzankov A et al (2012) The impact of aging on memory T cell phenotype and function in the human bone marrow. J Leukoc Biol 91:197–205
pubmed: 22013229
doi: 10.1189/jlb.0611299
Ho WZ, Harouse JM, Rando RF et al (1990) Reciprocal enhancement of gene expression and viral replication between human cytomegalovirus and human immunodeficiency virus type 1. J Gen Virol 71(Pt 1):97–103
pubmed: 2154540
doi: 10.1099/0022-1317-71-1-97
Hoehl S, Berger A, Ciesek S, Rabenau HF (2020) Thirty years of CMV seroprevalence-a longitudinal analysis in a German university hospital. Eur J Clin Microbiol Infect Dis 39:1095–1102
pubmed: 31989374
pmcid: 7225192
doi: 10.1007/s10096-020-03814-x
Holtzman CW, Trotman HD, Goulding SM et al (2013) Stress and neurodevelopmental processes in the emergence of psychosis. Neuroscience 249:172–191
pubmed: 23298853
doi: 10.1016/j.neuroscience.2012.12.017
Houenou J, d’Albis M-A, Daban C et al (2014) Cytomegalovirus seropositivity and serointensity are associated with hippocampal volume and verbal memory in schizophrenia and bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 48:142–148
pubmed: 24083998
doi: 10.1016/j.pnpbp.2013.09.003
Huang Z-F, Zou H-M, Liao B-W et al (2018) Human cytomegalovirus protein UL31 inhibits DNA sensing of cGAS to mediate immune evasion. Cell Host Microbe 24:69–80.e4
pubmed: 29937271
doi: 10.1016/j.chom.2018.05.007
Hung Y-Y, Kang H-Y, Huang K-W, Huang T-L (2014) Association between toll-like receptors expression and major depressive disorder. Psychiatry Res 220:283–286
pubmed: 25155940
doi: 10.1016/j.psychres.2014.07.074
Hunt PW, Martin JN, Sinclair E et al (2011) Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy. J Infect Dis 203:1474–1483
pubmed: 21502083
pmcid: 3080892
doi: 10.1093/infdis/jir060
Imlay H, Limaye AP (2020) Current understanding of cytomegalovirus reactivation in critical illness. J Infect Dis 221:S94–S102
pubmed: 32134490
pmcid: 7057786
doi: 10.1093/infdis/jiz638
Iñigo-Marco I, Alonso MM (2019) Destress and do not suppress: targeting adrenergic signaling in tumor immunosuppression. J Clin Invest. https://doi.org/10.1172/JCI133115
Irwin MR, Cole SW (2011) Reciprocal regulation of the neural and innate immune systems. Nat Rev Immunol 11:625–632
pubmed: 21818124
pmcid: 3597082
doi: 10.1038/nri3042
Isaacson MK, Juckem LK, Compton T (2008) Virus entry and innate immune activation. Curr Top Microbiol Immunol 325:85–100
pubmed: 18637501
Isnard S, Ramendra R, Lin J et al (2021) Anti-cytomegalovirus immunoglobulin G is linked to CD4 T-cell count decay in human immunodeficiency virus (HIV) elite controllers. Clin Infect Dis 73:144–147
pubmed: 32756974
doi: 10.1093/cid/ciaa1129
Ito S, Pophali P, Co W et al (2013) CMV reactivation is associated with a lower incidence of relapse after allo-SCT for CML. Bone Marrow Transplant 48:1313–1316
pubmed: 23562969
pmcid: 5274543
doi: 10.1038/bmt.2013.49
Iwaszko M, Bogunia-Kubik K (2011) Clinical significance of the HLA-E and CD94/NKG2 interaction. Arch Immunol Ther Exp (Warsz) 59:353–367
pubmed: 21800130
doi: 10.1007/s00005-011-0137-y
Janicki-Deverts D, Cohen S, Doyle WJ et al (2014) Childhood environments and cytomegalovirus serostatus and reactivation in adults. Brain Behav Immun 40:174–181
pubmed: 24675032
pmcid: 4102652
doi: 10.1016/j.bbi.2014.03.010
Jaremka LM, Fagundes CP, Glaser R et al (2013) Loneliness predicts pain, depression, and fatigue: understanding the role of immune dysregulation. Psychoneuroendocrinology 38:1310–1317
pubmed: 23273678
doi: 10.1016/j.psyneuen.2012.11.016
Jones TR, Sun L (1997) Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chains. J Virol 71:2970–2979
pubmed: 9060656
pmcid: 191425
doi: 10.1128/jvi.71.4.2970-2979.1997
Kadambari S, Klenerman P, Pollard AJ (2020) Why the elderly appear to be more severely affected by COVID-19: The potential role of immunosenescence and CMV. Rev Med Virol 30:e2144
pubmed: 32671966
pmcid: 7404358
doi: 10.1002/rmv.2144
Kalejta RF (2008) Functions of human cytomegalovirus tegument proteins prior to immediate early gene expression. Curr Top Microbiol Immunol 325:101–115
pubmed: 18637502
Kalil AC (2008) A silent killer: cytomegalovirus infection in the nonimmunocompromised critically ill patient. Crit Care Med 36:3261–3264
pubmed: 19020435
doi: 10.1097/CCM.0b013e31818f24c3
Kalil AC, Florescu DF (2011) Is cytomegalovirus reactivation increasing the mortality of patients with severe sepsis? Crit Care 15:138
pubmed: 21457496
pmcid: 3219353
doi: 10.1186/cc10093
Kananen L, Nevalainen T, Jylhävä J et al (2015) Cytomegalovirus infection accelerates epigenetic aging. Exp Gerontol 72:227–229
pubmed: 26485162
doi: 10.1016/j.exger.2015.10.008
Kaufmann C, Weinberger D, Yolken R et al (1983) Viruses and schizophrenia. Lancet 322:1136–1137
doi: 10.1016/S0140-6736(83)90645-1
Kendler KS, Karkowski LM, Prescott CA (1999) Causal relationship between stressful life events and the onset of major depression. Am J Psychiatry 156:837–841
pubmed: 10360120
doi: 10.1176/ajp.156.6.837
Kendler KS, Thornton LM, Gardner CO (2000) Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the “kindling” hypothesis. Am J Psychiatry 157:1243–1251
pubmed: 10910786
doi: 10.1176/appi.ajp.157.8.1243
Kenneson A, Cannon MJ (2007) Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol 17:253–276
pubmed: 17579921
doi: 10.1002/rmv.535
Kessler RC (1997) The effects of stressful life events on depression. Annu Rev Psychol 48:191–214
pubmed: 9046559
doi: 10.1146/annurev.psych.48.1.191
Khan N, Hislop A, Gudgeon N et al (2004) Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection. J Immunol 173:7481–7489
pubmed: 15585874
doi: 10.4049/jimmunol.173.12.7481
Klenerman P, Oxenius A (2016) T cell responses to cytomegalovirus. Nat Rev Immunol 16:367–377
pubmed: 27108521
doi: 10.1038/nri.2016.38
Kohrt BA, Worthman CM, Adhikari RP et al (2016) Psychological resilience and the gene regulatory impact of posttraumatic stress in Nepali child soldiers. Proc Natl Acad Sci U S A 113:8156–8161
pubmed: 27402736
pmcid: 4961140
doi: 10.1073/pnas.1601301113
Kolmus K, Tavernier J, Gerlo S (2015) β2-Adrenergic receptors in immunity and inflammation: stressing NF-κB. Brain Behav Immun 45:297–310
pubmed: 25459102
doi: 10.1016/j.bbi.2014.10.007
Kosugi I, Kawasaki H, Arai Y, Tsutsui Y (2002) Innate immune responses to cytomegalovirus infection in the developing mouse brain and their evasion by virus-infected neurons. Am J Pathol 161:919–928
pubmed: 12213720
pmcid: 1867268
doi: 10.1016/S0002-9440(10)64252-6
Kovacs A, Schluchter M, Easley K et al (1999) Cytomegalovirus infection and HIV-1 disease progression in infants born to HIV-1-infected women. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Group. N Engl J Med 341:77–84
pubmed: 10395631
pmcid: 4280563
doi: 10.1056/NEJM199907083410203
Lachmann R, Loenenbach A, Waterboer T et al (2018) Cytomegalovirus (CMV) seroprevalence in the adult population of Germany. PLoS One 13:e0200267
pubmed: 30044826
pmcid: 6059406
doi: 10.1371/journal.pone.0200267
Lambe G, Mansukhani D, Khodaiji S et al (2022) Immune modulation and cytomegalovirus reactivation in sepsis-induced immunosuppression: a pilot study. Indian J Crit Care Med 26:53–61
pubmed: 35110845
pmcid: 8783232
doi: 10.5005/jp-journals-10071-24079
Landais I, Pelton C, Streblow D et al (2015) Human cytomegalovirus miR-UL112-3p targets TLR2 and modulates the TLR2/IRAK1/NFκB signaling pathway. PLoS Pathog 11:e1004881
pubmed: 25955717
pmcid: 4425655
doi: 10.1371/journal.ppat.1004881
Le Balc’h P, Pinceaux K, Pronier C et al (2020) Herpes simplex virus and cytomegalovirus reactivations among severe COVID-19 patients. Crit Care 24:530
pubmed: 32859241
pmcid: 7453668
doi: 10.1186/s13054-020-03252-3
Lee AW, Wang N, Hornell TMC et al (2011) Human cytomegalovirus decreases constitutive transcription of MHC class II genes in mature Langerhans cells by reducing CIITA transcript levels. Mol Immunol 48:1160–1167
pubmed: 21458073
pmcid: 3086682
doi: 10.1016/j.molimm.2011.02.010
Lex C, Bäzner E, Meyer TD (2017) Does stress play a significant role in bipolar disorder? A meta-analysis. J Affect Disord 208:298–308
pubmed: 27794254
doi: 10.1016/j.jad.2016.08.057
Li Z, Tang Y, Tang N et al (2017) High anti-human cytomegalovirus antibody levels are associated with the progression of essential hypertension and target organ damage in Han Chinese population. PLoS One 12:e0181440
pubmed: 28837559
pmcid: 5570371
doi: 10.1371/journal.pone.0181440
Lichtner M, Cicconi P, Vita S et al (2015) Cytomegalovirus coinfection is associated with an increased risk of severe non-AIDS-defining events in a large cohort of HIV-infected patients. J Infect Dis 211:178–186
pubmed: 25081936
doi: 10.1093/infdis/jiu417
Lim EY, Jackson SE, Wills MR (2020) The CD4+ T cell response to human cytomegalovirus in healthy and immunocompromised people. Front Cell Infect Microbiol 10:202
pubmed: 32509591
pmcid: 7248300
doi: 10.3389/fcimb.2020.00202
Limaye AP, Stapleton RD, Peng L et al (2017) Effect of ganciclovir on IL-6 levels among cytomegalovirus-seropositive adults with critical illness: a randomized clinical trial. JAMA 318:731–740
pubmed: 28829877
pmcid: 5817487
doi: 10.1001/jama.2017.10569
Lin Z, Gao H, Wang B, Wang Y (2021) Cytomegalovirus infection and its relationship with leukocyte telomere length: a cross-sectional study. Mediators Inflamm 2021:6675353
pubmed: 33628118
pmcid: 7899777
doi: 10.1155/2021/6675353
Lindau P, Mukherjee R, Gutschow MV et al (2019) Cytomegalovirus exposure in the elderly does not reduce CD8 T cell repertoire diversity. J Immunol 202:476–483
pubmed: 30541882
doi: 10.4049/jimmunol.1800217
Liu F, Zhou ZH (2011) Comparative virion structures of human herpesviruses. In: Arvin A, Campadelli-Fiume G, Mocarski E et al (eds) Human herpesviruses: biology, therapy, and immunoprophylaxis. Cambridge University Press, Cambridge
Liu X-F, Jie C, Zhang Z et al (2016) Transplant-induced reactivation of murine cytomegalovirus immediate early gene expression is associated with recruitment of NF-κB and AP-1 to the major immediate early promoter. J Gen Virol 97:941–954
pubmed: 26795571
pmcid: 4854367
doi: 10.1099/jgv.0.000407
Ljungman P, Boeckh M, Hirsch HH et al (2017) Definitions of cytomegalovirus infection and disease in transplant patients for use in clinical trials. Clin Infect Dis 64:87–91
pubmed: 27682069
doi: 10.1093/cid/ciw668
Lönnqvist B, Ringdèn O, Ljungman P et al (1986) Reduced risk of recurrent leukaemia in bone marrow transplant recipients after cytomegalovirus infection. Br J Haematol 63:671–679
pubmed: 3015193
doi: 10.1111/j.1365-2141.1986.tb07551.x
Luetke-Eversloh M, Hammer Q, Durek P et al (2014) Human cytomegalovirus drives epigenetic imprinting of the IFNG locus in NKG2Chi natural killer cells. PLoS Pathog 10:e1004441
pubmed: 25329659
pmcid: 4199780
doi: 10.1371/journal.ppat.1004441
Maillet F, Pourbaix A, le Pluart D et al (2021) Cytomegalovirus proctitis as a complication of COVID-19 with immunosuppressive treatments. IDCases 24:e01111
pubmed: 33842207
pmcid: 8020601
doi: 10.1016/j.idcr.2021.e01111
Marshall EE, Geballe AP (2009) Multifaceted evasion of the interferon response by cytomegalovirus. J Interferon Cytokine Res 29:609–619
pubmed: 19708810
pmcid: 2743745
doi: 10.1089/jir.2009.0064
Martinez L, Nicol MP, Wedderburn CJ et al (2021) Cytomegalovirus acquisition in infancy and the risk of tuberculosis disease in childhood: a longitudinal birth cohort study in Cape Town, South Africa. Lancet Glob Health 9:e1740–e1749
pubmed: 34798032
pmcid: 8609281
doi: 10.1016/S2214-109X(21)00407-1
Martland N, Martland R, Cullen AE, Bhattacharyya S (2020) Are adult stressful life events associated with psychotic relapse? A systematic review of 23 studies. Psychol Med 50:2302–2316
pubmed: 33054892
doi: 10.1017/S0033291720003554
McDonald K, Rector TS, Braulin EA et al (1989) Association of coronary artery disease in cardiac transplant recipients with cytomegalovirus infection. Am J Cardiol 64:359–362
pubmed: 2547298
doi: 10.1016/0002-9149(89)90535-3
McDonald S, Maguire G, Duarte N et al (2004) C-reactive protein, cardiovascular risk, and renal disease in a remote Australian Aboriginal community. Clin Sci (Lond) 106:121–128
pubmed: 12956621
doi: 10.1042/CS20030186
McNab F, Mayer-Barber K, Sher A et al (2015) Type I interferons in infectious disease. Nat Rev Immunol 15:87–103
pubmed: 25614319
pmcid: 7162685
doi: 10.1038/nri3787
Mechawar N, Savitz J (2016) Neuropathology of mood disorders: do we see the stigmata of inflammation? Transl Psychiatry 6:e946
pubmed: 27824355
pmcid: 5314124
doi: 10.1038/tp.2016.212
Mehta SK, Stowe RP, Feiveson AH et al (2000) Reactivation and shedding of cytomegalovirus in astronauts during spaceflight. J Infect Dis 182:1761–1764
pubmed: 11069250
doi: 10.1086/317624
Meltzer-Brody S, Larsen JT, Petersen L et al (2018) Adverse life events increase risk for postpartum psychiatric episodes: a population-based epidemiologic study. Depress Anxiety 35:160–167
pubmed: 29172228
doi: 10.1002/da.22697
Miller AH, Raison CL (2016) The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat Rev Immunol 16:22–34
pubmed: 26711676
pmcid: 5542678
doi: 10.1038/nri.2015.5
Miller GE, Freedland KE, Duntley S, Carney RM (2005) Relation of depressive symptoms to C-reactive protein and pathogen burden (cytomegalovirus, herpes simplex virus, Epstein-Barr virus) in patients with earlier acute coronary syndromes. Am J Cardiol 95:317–321
pubmed: 15670537
doi: 10.1016/j.amjcard.2004.09.026
Min C-K, Shakya AK, Lee B-J et al (2020) The differentiation of human cytomegalovirus infected-monocytes is required for viral replication. Front Cell Infect Microbiol 10:368
pubmed: 32850474
pmcid: 7411144
doi: 10.3389/fcimb.2020.00368
Mittal SK, Roche PA (2015) Suppression of antigen presentation by IL-10. Curr Opin Immunol 34:22–27
pubmed: 25597442
pmcid: 4444374
doi: 10.1016/j.coi.2014.12.009
Mohammadpour H, O’Neil R, Qiu J et al (2018) Blockade of Host β2-adrenergic receptor enhances graft-versus-tumor effect through modulating APCs. J Immunol 200:2479–2488
pubmed: 29445008
doi: 10.4049/jimmunol.1701752
Molaei H, Khedmat L, Nemati E et al (2021) Iranian kidney transplant recipients with COVID-19 infection: Clinical outcomes and cytomegalovirus coinfection. Transpl Infect Dis 23:e13455
pubmed: 32881220
doi: 10.1111/tid.13455
Moreno-Peral P, Conejo-Cerón S, Motrico E et al (2014) Risk factors for the onset of panic and generalised anxiety disorders in the general adult population: a systematic review of cohort studies. J Affect Disord 168:337–348
pubmed: 25089514
doi: 10.1016/j.jad.2014.06.021
Moss P (2019) “From immunosenescence to immune modulation”: a re-appraisal of the role of cytomegalovirus as major regulator of human immune function. Med Microbiol Immunol 208:271–280
pubmed: 31053999
doi: 10.1007/s00430-019-00612-x
Müller J, Tanner R, Matsumiya M et al (2019) Cytomegalovirus infection is a risk factor for tuberculosis disease in infants. JCI Insight 4. https://doi.org/10.1172/jci.insight.130090
Murph JR, Bale JF Jr, Murray JC et al (1986) Cytomegalovirus transmission in a midwest day care center: possible relationship to child care practices. J Pediatr 109:35–39
pubmed: 3014103
doi: 10.1016/S0022-3476(86)80568-6
Murray MJ, Bonilla-Medrano NI, Lee QL et al (2020) Evasion of a human cytomegalovirus entry inhibitor with potent cysteine reactivity is concomitant with the utilization of a heparan sulfate proteoglycan-independent route of entry. J Virol 94. https://doi.org/10.1128/JVI.02012-19
Myerson D, Hackman RC, Nelson JA et al (1984) Widespread presence of histologically occult cytomegalovirus. Hum Pathol 15:430–439
pubmed: 6327494
doi: 10.1016/S0046-8177(84)80076-3
Nachtwey J, Spencer JV (2008) HCMV IL-10 suppresses cytokine expression in monocytes through inhibition of nuclear factor-kappaB. Viral Immunol 21:477–482
pubmed: 19115937
pmcid: 2831744
doi: 10.1089/vim.2008.0048
Nardiello S, Digilio L, Pizzella T, Galanti B (1994) Cytomegalovirus as a co-factor of disease progression in human immunodeficiency virus type 1 infection. Int J Clin Lab Res 24:86–89
pubmed: 7919433
doi: 10.1007/BF02593905
Netterwald JR, Jones TR, Britt WJ et al (2004) Postattachment events associated with viral entry are necessary for induction of interferon-stimulated genes by human cytomegalovirus. J Virol 78:6688–6691
pubmed: 15163760
pmcid: 416537
doi: 10.1128/JVI.78.12.6688-6691.2004
Nikitina E, Larionova I, Choinzonov E, Kzhyshkowska J (2018) Monocytes and macrophages as viral targets and reservoirs. Int J Mol Sci 19. https://doi.org/10.3390/ijms19092821
Noppert GA, Feinstein L, Dowd JB et al (2020) Pathogen burden and leukocyte telomere length in the United States. Immun Ageing 17:36
pubmed: 33292353
pmcid: 7677839
doi: 10.1186/s12979-020-00206-9
Norman RM, Malla AK (1993) Stressful life events and schizophrenia. I: a review of the research. Br J Psychiatry 162:161–166
pubmed: 8435685
doi: 10.1192/bjp.162.2.161
Noyola DE, Valdez-López BH, Hernández-Salinas AE et al (2005) Cytomegalovirus excretion in children attending day-care centers. Arch Med Res 36:590–593
pubmed: 16099343
doi: 10.1016/j.arcmed.2005.03.045
Olbrich L, Stockdale L, Basu Roy R et al (2021) Understanding the interaction between cytomegalovirus and tuberculosis in children: the way forward. PLoS Pathog 17:e1010061
pubmed: 34882748
pmcid: 8659711
doi: 10.1371/journal.ppat.1010061
Oliveira-Nascimento L, Massari P, Wetzler LM (2012) The role of TLR2 in infection and immunity. Front Immunol 3:79
pubmed: 22566960
pmcid: 3342043
doi: 10.3389/fimmu.2012.00079
Olsson J, Wikby A, Johansson B et al (2000) Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev 121:187–201
pubmed: 11164473
doi: 10.1016/S0047-6374(00)00210-4
Oualim S, Elouarradi A, Hafid S et al (2020) A misleading CMV myocarditis during the COVID-19 pandemic: case report. Pan Afr Med J 36. https://doi.org/10.11604/pamj.2020.36.167.23922
Paijo J, Döring M, Spanier J et al (2016) cGAS senses human cytomegalovirus and induces type I interferon responses in human monocyte-derived cells. PLoS Pathog 12:e1005546
pubmed: 27058035
pmcid: 4825940
doi: 10.1371/journal.ppat.1005546
Palmer DB (2013) The effect of age on thymic function. Front Immunol 4:316
pubmed: 24109481
pmcid: 3791471
doi: 10.3389/fimmu.2013.00316
Pangrazzi L, Weinberger B (2020) T cells, aging and senescence. Exp Gerontol 134:110887
pubmed: 32092501
doi: 10.1016/j.exger.2020.110887
Pape K, Tamouza R, Leboyer M, Zipp F (2019) Immunoneuropsychiatry – novel perspectives on brain disorders. Nat Rev Neurol. https://doi.org/10.1038/s41582-019-0174-4
Pariante CM, Carpiniello B, Orrù MG et al (1997) Chronic caregiving stress alters peripheral blood immune parameters: the role of age and severity of stress. Psychother Psychosom 66:199–207
pubmed: 9259043
doi: 10.1159/000289135
Park A, Ra EA, Lee TA et al (2019) HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways. Nat Commun 10:4670
pubmed: 31604943
pmcid: 6789044
doi: 10.1038/s41467-019-12641-4
Parry HM, Dowell AC, Zuo J et al (2021) PD-1 is imprinted on cytomegalovirus-specific CD4+ T cells and attenuates Th1 cytokine production whilst maintaining cytotoxicity. PLoS Pathog 17:e1009349
pubmed: 33662046
pmcid: 7963093
doi: 10.1371/journal.ppat.1009349
Pass RF, Hutto C, Lyon MD, Cloud G (1990) Increased rate of cytomegalovirus infection among day care center workers. Pediatr Infect Dis J 9:465–470
pubmed: 1973533
doi: 10.1097/00006454-199007000-00003
Patel AA, Zhang Y, Fullerton JN et al (2017a) The fate and lifespan of human monocyte subsets in steady state and systemic inflammation. J Exp Med 214:1913–1923
pubmed: 28606987
pmcid: 5502436
doi: 10.1084/jem.20170355
Patel EU, Gianella S, Newell K et al (2017b) Elevated cytomegalovirus IgG antibody levels are associated with HIV-1 disease progression and immune activation. AIDS 31:807–813
pubmed: 28121712
doi: 10.1097/QAD.0000000000001412
Pathirana J, Kwatra G, Maposa I et al (2021) Effect of cytomegalovirus infection on humoral immune responses to select vaccines administered during infancy. Vaccine 39:4793–4799
pubmed: 34275675
doi: 10.1016/j.vaccine.2021.05.066
Patrick EJ, Higgins CD, Crawford DH, McAulay KA (2014) A cohort study in university students: investigation of risk factors for cytomegalovirus infection. Epidemiol Infect 142:1990–1995
pubmed: 24160893
doi: 10.1017/S0950268813002720
Pawelec G, Ferguson FG, Wikby A (2001) The SENIEUR protocol after 16 years. Mech Ageing Dev 122:132–134
pubmed: 11166351
doi: 10.1016/S0047-6374(00)00240-2
Pawelec G, Akbar A, Caruso C et al (2005) Human immunosenescence: is it infectious? Immunol Rev 205:257–268
pubmed: 15882359
doi: 10.1111/j.0105-2896.2005.00271.x
Pawelec G, Derhovanessian E, Larbi A et al (2009) Cytomegalovirus and human immunosenescence. Rev Med Virol 19:47–56
pubmed: 19035529
doi: 10.1002/rmv.598
Phillips AC, Carroll D, Khan N, Moss P (2008) Cytomegalovirus is associated with depression and anxiety in older adults. Brain Behav Immun 22:52–55
pubmed: 17703915
doi: 10.1016/j.bbi.2007.06.012
Pillinger T, Osimo EF, Brugger S et al (2019) A meta-analysis of immune parameters, variability, and assessment of modal distribution in psychosis and test of the immune subgroup hypothesis. Schizophr Bull 45:1120–1133
pubmed: 30407606
doi: 10.1093/schbul/sby160
Poloni C, Szyf M, Cheishvili D, Tsoukas CM (2021) Are the healthy vulnerable? Cytomegalovirus seropositivity in healthy adults is associated with accelerated epigenetic age and immune-dysregulation. J Infect Dis. https://doi.org/10.1093/infdis/jiab365
Poole E, Lau JCH, Sinclair J (2015) Latent infection of myeloid progenitors by human cytomegalovirus protects cells from FAS-mediated apoptosis through the cellular IL-10/PEA-15 pathway. J Gen Virol 96:2355–2359
pubmed: 25957098
pmcid: 4681070
doi: 10.1099/vir.0.000180
Poole E, Neves TC, Oliveira MT et al (2020) Human cytomegalovirus interleukin 10 homologs: facing the immune system. Front Cell Infect Microbiol 10:245
pubmed: 32582563
pmcid: 7296156
doi: 10.3389/fcimb.2020.00245
Prod’homme V, Tomasec P, Cunningham C et al (2012) Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18. J Immunol 188:2794–2804
pubmed: 22345649
doi: 10.4049/jimmunol.1102068
Prösch S, Wendt CE, Reinke P et al (2000) A novel link between stress and human cytomegalovirus (HCMV) infection: sympathetic hyperactivity stimulates HCMV activation. Virology 272:357–365
pubmed: 10873779
doi: 10.1006/viro.2000.0367
Prossin AR, Yolken RH, Kamali M et al (2015) Cytomegalovirus antibody elevation in bipolar disorder: relation to elevated mood states. Neural Plast 2015:939780
pubmed: 26075105
pmcid: 4444593
doi: 10.1155/2015/939780
Rector JL, Dowd JB, Loerbroks A et al (2014) Consistent associations between measures of psychological stress and CMV antibody levels in a large occupational sample. Brain Behav Immun 38:133–141
pubmed: 24472683
doi: 10.1016/j.bbi.2014.01.012
Reed RG, Greenberg RN, Segerstrom SC (2017) Cytomegalovirus serostatus, inflammation, and antibody response to influenza vaccination in older adults: the moderating effect of beta blockade. Brain Behav Immun 61:14–20
pubmed: 27720816
doi: 10.1016/j.bbi.2016.09.025
Reed RG, Presnell SR, Al-Attar A et al (2019) Perceived stress, cytomegalovirus titers, and late-differentiated T and NK cells: Between-, within-person associations in a longitudinal study of older adults. Brain Behav Immun. https://doi.org/10.1016/j.bbi.2019.03.018
Reeves MB, Compton T (2011) Inhibition of inflammatory interleukin-6 activity via extracellular signal-regulated kinase-mitogen-activated protein kinase signaling antagonizes human cytomegalovirus reactivation from dendritic cells. J Virol 85:12750–12758
pubmed: 21937636
pmcid: 3209367
doi: 10.1128/JVI.05878-11
Reeves MB, Sinclair JH (2010) Analysis of latent viral gene expression in natural and experimental latency models of human cytomegalovirus and its correlation with histone modifications at a latent promoter. J Gen Virol 91:599–604
pubmed: 19906945
doi: 10.1099/vir.0.015602-0
Reeves MB, Sinclair JH (2013) Circulating dendritic cells isolated from healthy seropositive donors are sites of human cytomegalovirus reactivation in vivo. J Virol 87:10660–10667
pubmed: 23885077
pmcid: 3807413
doi: 10.1128/JVI.01539-13
Rizzo LB, Do Prado CH, Grassi-Oliveira R et al (2013) Immunosenescence is associated with human cytomegalovirus and shortened telomeres in type I bipolar disorder. Bipolar Disord 15:832–838
pubmed: 24021055
doi: 10.1111/bdi.12121
Robain M, Boufassa F, Hubert JB et al (2001) Cytomegalovirus seroconversion as a cofactor for progression to AIDS. AIDS 15:251–256
pubmed: 11216935
doi: 10.1097/00002030-200101260-00016
Roberts ET, Haan MN, Dowd JB, Aiello AE (2010) Cytomegalovirus antibody levels, inflammation, and mortality among elderly Latinos over 9 years of follow-up. Am J Epidemiol 172:363–371
pubmed: 20660122
pmcid: 2950794
doi: 10.1093/aje/kwq177
Rölle A, Brodin P (2016) Immune adaptation to environmental influence: the case of NK cells and HCMV. Trends Immunol 37:233–243
pubmed: 26869205
doi: 10.1016/j.it.2016.01.005
Rölle A, Pollmann J, Ewen E-M et al (2014) IL-12-producing monocytes and HLA-E control HCMV-driven NKG2C+ NK cell expansion. J Clin Invest 124:5305–5316
pubmed: 25384219
pmcid: 4348979
doi: 10.1172/JCI77440
Rush AJ (2003) Toward an understanding of bipolar disorder and its origin. J Clin Psychiatry 64(Suppl 6):4–8. discussion 28
pubmed: 12720474
Sandhu PK, Buchkovich NJ (2020) Human cytomegalovirus decreases major histocompatibility complex class II by regulating class II transactivator transcript levels in a myeloid cell line. J Virol 94. https://doi.org/10.1128/JVI.01901-19
Sasaki S, Sullivan M, Narvaez CF et al (2011) Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies. J Clin Invest 121:3109–3119
pubmed: 21785218
pmcid: 3148747
doi: 10.1172/JCI57834
Savitz J (2019) The kynurenine pathway: a finger in every pie. Mol Psychiatry. https://doi.org/10.1038/s41380-019-0414-4
Savitz J, Harrison NA (2018) Interoception and inflammation in psychiatric disorders. Biol Psychiatry Cogn Neurosci Neuroimaging 3:514–524
pubmed: 29884282
pmcid: 5995132
Savva GM, Pachnio A, Kaul B et al (2013) Cytomegalovirus infection is associated with increased mortality in the older population. Aging Cell 12:381–387
pubmed: 23442093
doi: 10.1111/acel.12059
Schmaltz HN, Fried LP, Xue Q-L et al (2005) Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women. J Am Geriatr Soc 53:747–754
pubmed: 15877548
doi: 10.1111/j.1532-5415.2005.53250.x
Schmidt D, Peterlik D, Reber SO et al (2016) Induction of suppressor cells and increased tumor growth following chronic psychosocial stress in male mice. PLoS One 11:e0159059
pubmed: 27391954
pmcid: 4938385
doi: 10.1371/journal.pone.0159059
Schnittman SR, Hunt PW (2021) Clinical consequences of asymptomatic cytomegalovirus in treated human immunodeficency virus infection. Curr Opin HIV AIDS 16:168–176
pubmed: 33833209
pmcid: 8238090
doi: 10.1097/COH.0000000000000678
Selvey LA, Lim WH, Boan P et al (2017) Cytomegalovirus viraemia and mortality in renal transplant recipients in the era of antiviral prophylaxis. Lessons from the western Australian experience. BMC Infect Dis 17:501
pubmed: 28716027
pmcid: 5514475
doi: 10.1186/s12879-017-2599-y
Semmes EC, Hurst JH, Walsh KM, Permar SR (2020) Cytomegalovirus as an immunomodulator across the lifespan. Curr Opin Virol 44:112–120
pubmed: 32818717
pmcid: 7755826
doi: 10.1016/j.coviro.2020.07.013
Shaikh AS, Shaim H, Caravedo MA et al (2021) A new viral coinfection: SARS-CoV-2 pneumonia and cytomegalovirus pneumonitis in a renal transplant recipient. COVID 1:115–119
doi: 10.3390/covid1010010
Sharpe HR, Provine NM, Bowyer GS et al (2022) CMV-associated T cell and NK cell terminal differentiation does not affect immunogenicity of ChAdOx1 vaccination. JCI Insight 7. https://doi.org/10.1172/jci.insight.154187
Shimba A, Ikuta K (2020) Control of immunity by glucocorticoids in health and disease. Semin Immunopathol. https://doi.org/10.1007/s00281-020-00827-8
Shrock E, Fujimura E, Kula T et al (2020) Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity. Science 370. https://doi.org/10.1126/science.abd4250
Simanek AM, Dowd JB, Pawelec G et al (2011) Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States. PLoS One 6:e16103
pubmed: 21379581
pmcid: 3040745
doi: 10.1371/journal.pone.0016103
Simanek AM, Cheng C, Yolken R et al (2014) Herpesviruses, inflammatory markers and incident depression in a longitudinal study of Detroit residents. Psychoneuroendocrinology 50:139–148
pubmed: 25218654
pmcid: 4306348
doi: 10.1016/j.psyneuen.2014.08.002
Simanek AM, Zheng C, Yolken R et al (2018) A longitudinal study of the association between persistent pathogens and incident depression among older US Latinos. J Gerontol A Biol Sci Med Sci. https://doi.org/10.1093/gerona/gly172
Simmen KA, Singh J, Luukkonen BG et al (2001) Global modulation of cellular transcription by human cytomegalovirus is initiated by viral glycoprotein B. Proc Natl Acad Sci U S A 98:7140–7145
pubmed: 11390970
pmcid: 34636
doi: 10.1073/pnas.121177598
Simonnet A, Engelmann I, Moreau A-S et al (2021) High incidence of Epstein-Barr virus, cytomegalovirus, and human-herpes virus-6 reactivations in critically ill patients with COVID-19. Infect Dis Now 51:296–299
pubmed: 33495765
pmcid: 7816954
doi: 10.1016/j.idnow.2021.01.005
Sinicco A, Raiteri R, Sciandra M et al (1997) The influence of cytomegalovirus on the natural history of HIV infection: evidence of rapid course of HIV infection in HIV-positive patients infected with cytomegalovirus. Scand J Infect Dis 29:543–549
pubmed: 9571731
doi: 10.3109/00365549709035891
Sinzger C, Digel M, Jahn G (2008) Cytomegalovirus cell tropism. In: Shenk TE, Stinski MF (eds) Human cytomegalovirus. Springer, Berlin, pp 63–83
doi: 10.1007/978-3-540-77349-8_4
Smith EM, Cadet P, Stefano GB et al (1999) IL-10 as a mediator in the HPA axis and brain. J Neuroimmunol 100:140–148
pubmed: 10695724
doi: 10.1016/S0165-5728(99)00206-4
Smith NA, Chan GC, O’Connor CM (2021) Modulation of host cell signaling during cytomegalovirus latency and reactivation. Virol J 18:207
pubmed: 34663377
pmcid: 8524946
doi: 10.1186/s12985-021-01674-1
Söderberg-Nauclér C, Fish KN, Nelson JA (1997a) Reactivation of latent human cytomegalovirus by allogeneic stimulation of blood cells from healthy donors. Cell 91:119–126
pubmed: 9335340
doi: 10.1016/S0092-8674(01)80014-3
Söderberg-Nauclér C, Fish KN, Nelson JA (1997b) Interferon-gamma and tumor necrosis factor-alpha specifically induce formation of cytomegalovirus-permissive monocyte-derived macrophages that are refractory to the antiviral activity of these cytokines. J Clin Invest 100:3154–3163
pubmed: 9399963
pmcid: 508529
doi: 10.1172/JCI119871
Söderberg-Nauclér C, Streblow DN, Fish KN et al (2001) Reactivation of latent human cytomegalovirus in CD14(+) monocytes is differentiation dependent. J Virol 75:7543–7554
pubmed: 11462026
pmcid: 114989
doi: 10.1128/JVI.75.16.7543-7554.2001
Sølvsten Burgdorf K, Trabjerg B, Giørtz Pedersen M et al (2019) Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders. Brain Behav Immun. https://doi.org/10.1016/j.bbi.2019.01.026
Song BH, Lee GC, Moon MS et al (2001) Human cytomegalovirus binding to heparan sulfate proteoglycans on the cell surface and/or entry stimulates the expression of human leukocyte antigen class I. J Gen Virol 82:2405–2413
pubmed: 11562534
doi: 10.1099/0022-1317-82-10-2405
Spencer RL, Deak T (2017) A users guide to HPA axis research. Physiol Behav 178:43–65
pubmed: 27871862
doi: 10.1016/j.physbeh.2016.11.014
Spencer JV, Lockridge KM, Barry PA et al (2002) Potent immunosuppressive activities of cytomegalovirus-encoded interleukin-10. J Virol 76:1285–1292
pubmed: 11773404
pmcid: 135865
doi: 10.1128/JVI.76.3.1285-1292.2002
Spyridopoulos I, Hoffmann J, Aicher A et al (2009) Accelerated telomere shortening in leukocyte subpopulations of patients with coronary heart disease: role of cytomegalovirus seropositivity. Circulation 120:1364–1372
pubmed: 19770396
doi: 10.1161/CIRCULATIONAHA.109.854299
Staras SAS, Dollard SC, Radford KW et al (2006) Seroprevalence of cytomegalovirus infection in the United States, 1988-1994. Clin Infect Dis 43:1143–1151
pubmed: 17029132
doi: 10.1086/508173
Staras SAS, Flanders WD, Dollard SC et al (2008) Influence of sexual activity on cytomegalovirus seroprevalence in the United States, 1988-1994. Sex Transm Dis 35:472–479
pubmed: 18354346
doi: 10.1097/OLQ.0b013e3181644b70
Stein J, Volk HD, Liebenthal C et al (1993) Tumour necrosis factor alpha stimulates the activity of the human cytomegalovirus major immediate early enhancer/promoter in immature monocytic cells. J Gen Virol 74(Pt 11):2333–2338
pubmed: 8245850
doi: 10.1099/0022-1317-74-11-2333
Stein KR, Gardner TJ, Hernandez RE et al (2019) CD46 facilitates entry and dissemination of human cytomegalovirus. Nat Commun 10:2699
pubmed: 31221976
pmcid: 6586906
doi: 10.1038/s41467-019-10587-1
Stevenson EV, Collins-McMillen D, Kim JH et al (2014) HCMV reprogramming of infected monocyte survival and differentiation: a Goldilocks phenomenon. Viruses 6:782–807
pubmed: 24531335
pmcid: 3939482
doi: 10.3390/v6020782
Stinski MF, Meier JL (2011) Immediate–early viral gene regulation and function. In: Arvin A, Campadelli-Fiume G, Mocarski E et al (eds) Human herpesviruses: biology, therapy, and immunoprophylaxis. Cambridge University Press, Cambridge
Stockdale L, Nash S, Farmer R et al (2020) Cytomegalovirus antibody responses associated with increased risk of tuberculosis disease in Ugandan adults. J Infect Dis 221:1127–1134
pubmed: 31689350
Stowell JD, Forlin-Passoni D, Din E et al (2012) Cytomegalovirus survival on common environmental surfaces: opportunities for viral transmission. J Infect Dis 205:211–214
pubmed: 22116837
doi: 10.1093/infdis/jir722
Stowell JD, Forlin-Passoni D, Radford K et al (2014) Cytomegalovirus survival and transferability and the effectiveness of common hand-washing agents against cytomegalovirus on live human hands. Appl Environ Microbiol 80:455–461
pubmed: 24185855
pmcid: 3911075
doi: 10.1128/AEM.03262-13
Strandberg TE, Pitkala KH, Tilvis RS (2009) Cytomegalovirus antibody level and mortality among community-dwelling older adults with stable cardiovascular disease. JAMA 301:380–382
pubmed: 19176439
doi: 10.1001/jama.2009.4
Streblow DN, Nelson JA (2003) Models of HCMV latency and reactivation. Trends Microbiol 11:293–295
pubmed: 12875809
doi: 10.1016/S0966-842X(03)00149-5
Sylwester AW, Mitchell BL, Edgar JB et al (2005) Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med 202:673–685
pubmed: 16147978
pmcid: 2212883
doi: 10.1084/jem.20050882
Tanaka T, Matsuda T, Hayes LN et al (2017) Infection and inflammation in schizophrenia and bipolar disorder. Neurosci Res 115:59–63
pubmed: 27856235
doi: 10.1016/j.neures.2016.11.002
Taylor-Wiedeman J, Sissons P, Sinclair J (1994) Induction of endogenous human cytomegalovirus gene expression after differentiation of monocytes from healthy carriers. J Virol 68:1597–1604
pubmed: 8107221
pmcid: 236617
doi: 10.1128/jvi.68.3.1597-1604.1994
Tedla Y, Shibre T, Ali O et al (2011) Serum antibodies to Toxoplasma gondii and Herpesvidae family viruses in individuals with schizophrenia and bipolar disorder: a case-control study. Ethiop Med J 49:211–220
pubmed: 21991754
Tomazin R, Boname J, Hegde NR et al (1999) Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells. Nat Med 5:1039–1043
pubmed: 10470081
doi: 10.1038/12478
Torrey EF, Yolken RH, Winfrey CJ (1982) Cytomegalovirus antibody in cerebrospinal fluid of schizophrenic patients detected by enzyme immunoassay. Science 216:892–894
pubmed: 6281883
doi: 10.1126/science.6281883
Trzonkowski P, Myśliwska J, Szmit E et al (2003) Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination – an impact of immunosenescence. Vaccine 21:3826–3836
Trzonkowski P, Myśliwska J, Godlewska B et al (2004) Immune consequences of the spontaneous pro-inflammatory status in depressed elderly patients. Brain Behav Immun 18:135–148
pubmed: 14759591
doi: 10.1016/S0889-1591(03)00111-9
Turki AT, Tsachakis-Mück N, Leserer S et al (2022) Impact of CMV reactivation on relapse of acute myeloid leukemia after HCT is dependent on disease stage and ATG. Blood Adv 6:28–36
pubmed: 34619756
doi: 10.1182/bloodadvances.2021005509
Valantine HA, Gao SZ, Menon SG et al (1999) Impact of prophylactic immediate posttransplant ganciclovir on development of transplant atherosclerosis: a post hoc analysis of a randomized, placebo-controlled study. Circulation 100:61–66
pubmed: 10393682
doi: 10.1161/01.CIR.100.1.61
Valenzuela HF, Effros RB (2002) Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus. Clin Immunol 105:117–125
pubmed: 12482386
doi: 10.1006/clim.2002.5271
Van Damme E, Van Loock M (2014) Functional annotation of human cytomegalovirus gene products: an update. Front Microbiol 5:218
pubmed: 24904534
pmcid: 4032930
van de Berg PJEJ, Griffiths SJ, Yong S-L et al (2010) Cytomegalovirus infection reduces telomere length of the circulating T cell pool. J Immunol 184:3417–3423
pubmed: 20176738
doi: 10.4049/jimmunol.0903442
van den Berg SPH, Pardieck IN, Lanfermeijer J et al (2019a) The hallmarks of CMV-specific CD8 T-cell differentiation. Med Microbiol Immunol 208:365–373
pubmed: 30989333
pmcid: 6647465
doi: 10.1007/s00430-019-00608-7
van den Berg SPH, Warmink K, Borghans JAM et al (2019b) Effect of latent cytomegalovirus infection on the antibody response to influenza vaccination: a systematic review and meta-analysis. Med Microbiol Immunol 208:305–321
pubmed: 30949763
pmcid: 6647367
doi: 10.1007/s00430-019-00602-z
Vanarsdall AL, Johnson DC (2012) Human cytomegalovirus entry into cells. Curr Opin Virol 2:37–42
pubmed: 22440964
doi: 10.1016/j.coviro.2012.01.001
Wada H, Matsumoto N, Maenaka K et al (2004) The inhibitory NK cell receptor CD94/NKG2A and the activating receptor CD94/NKG2C bind the top of HLA-E through mostly shared but partly distinct sets of HLA-E residues. Eur J Immunol 34:81–90
pubmed: 14971033
doi: 10.1002/eji.200324432
Wall N, Godlee A, Geh D et al (2021) Latent cytomegalovirus infection and previous capsular polysaccharide vaccination predict poor vaccine responses in older adults, independent of chronic kidney disease. Clin Infect Dis. https://doi.org/10.1093/cid/ciab078
Walter EA, Greenberg PD, Gilbert MJ et al (1995) Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med 333:1038–1044
pubmed: 7675046
doi: 10.1056/NEJM199510193331603
Wang GC, Kao WHL, Murakami P et al (2010) Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort study. Am J Epidemiol 171:1144–1152
pubmed: 20400465
pmcid: 2877470
doi: 10.1093/aje/kwq062
Wang H, Peng G, Bai J et al (2017) Cytomegalovirus infection and relative risk of cardiovascular disease (ischemic heart disease, stroke, and cardiovascular death): a meta-analysis of prospective studies up to 2016. J Am Heart Assoc 6. https://doi.org/10.1161/JAHA.116.005025
Wang L, Verschuuren EAM, Paap D et al (2021) Ageing of immune system and response to a live-attenuated herpes zoster vaccine in lung transplant candidates. Vaccines (Basel) 9. https://doi.org/10.3390/vaccines9030202
Watanabe M, Torigoe S, Ito M et al (2019) Salivary cytomegalovirus excretion in children in daycare centers and home care facilities in Japan. J Med Virol 91:2182–2187
pubmed: 31378947
doi: 10.1002/jmv.25562
Webster A, Lee CA, Cook DG et al (1989) Cytomegalovirus infection and progression towards AIDS in haemophiliacs with human immunodeficiency virus infection. Lancet 2:63–66
pubmed: 2567870
doi: 10.1016/S0140-6736(89)90312-7
White EA, Spector DH (2011) Early viral gene expression and function. In: Arvin A, Campadelli-Fiume G, Mocarski E et al (eds) Human herpesviruses: biology, therapy, and immunoprophylaxis. Cambridge University Press, Cambridge
Wieduwild E, Girard-Madoux MJ, Quatrini L et al (2020) Β2-adrenergic signals downregulate the innate immune response and reduce host resistance to viral infection. J Exp Med 217. https://doi.org/10.1084/jem.20190554
Wiertz EJ, Jones TR, Sun L et al (1996) The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell 84:769–779
pubmed: 8625414
doi: 10.1016/S0092-8674(00)81054-5
Wikby A, Johansson B, Olsson J et al (2002) Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol 37:445–453
pubmed: 11772532
doi: 10.1016/S0531-5565(01)00212-1
Wikby A, Ferguson F, Forsey R et al (2005) An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans. J Gerontol A Biol Sci Med Sci 60:556–565
pubmed: 15972602
doi: 10.1093/gerona/60.5.556
Wills MR, Poole E, Lau B et al (2015) The immunology of human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies? Cell Mol Immunol 12:128–138
pubmed: 25132454
doi: 10.1038/cmi.2014.75
Woods E, Zaiatz-Bittencourt V, Bannan C et al (2021) Specific human cytomegalovirus signature detected in NK cell metabolic changes post vaccination. NPJ Vaccines 6:117
pubmed: 34584101
pmcid: 8478984
doi: 10.1038/s41541-021-00381-w
Yang YS, Ho HN, Chen HF et al (1995) Cytomegalovirus infection and viral shedding in the genital tract of infertile couples. J Med Virol 45:179–182
pubmed: 7775936
doi: 10.1002/jmv.1890450212
Ye L, Qian Y, Yu W et al (2020) Functional profile of human cytomegalovirus genes and their associated diseases: a review. Front Microbiol 11:2104
pubmed: 33013768
pmcid: 7498621
doi: 10.3389/fmicb.2020.02104
Yurochko AD, Huong SM, Huang ES (1999) Identification of human cytomegalovirus target sequences in the human immunodeficiency virus long terminal repeat. Potential role of IE2-86 binding to sequences between -120 and -20 in promoter transactivation. J Hum Virol 2:81–90
pubmed: 10225210
Zheng H, Ford BN, Bergamino M et al (2020) A hidden menace? Cytomegalovirus infection is associated with reduced cortical gray matter volume in major depressive disorder. Mol Psychiatry:1–11
Zheng H, Bergamino M, Ford BN et al (2021a) Replicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder. Neuropsychopharmacology. https://doi.org/10.1038/s41386-021-00971-1
Zheng H, Ford BN, Kuplicki R et al (2021b) Association between cytomegalovirus infection, reduced gray matter volume, and resting-state functional hypoconnectivity in major depressive disorder: a replication and extension. Transl Psychiatry 11:464
pubmed: 34493708
pmcid: 8423754
doi: 10.1038/s41398-021-01558-6
Zhu H, Cong JP, Mamtora G et al (1998) Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays. Proc Natl Acad Sci U S A 95:14470–14475
pubmed: 9826724
pmcid: 24397
doi: 10.1073/pnas.95.24.14470
Zhu D, Pan C, Sheng J et al (2018) Human cytomegalovirus reprogrammes haematopoietic progenitor cells into immunosuppressive monocytes to achieve latency. Nat Microbiol 3:503–513
pubmed: 29588542
pmcid: 6537872
doi: 10.1038/s41564-018-0131-9
Zhuravskaya T, Maciejewski JP, Netski DM et al (1997) Spread of human cytomegalovirus (HCMV) after infection of human hematopoietic progenitor cells: model of HCMV latency. Blood 90:2482–2491
pubmed: 9310501
doi: 10.1182/blood.V90.6.2482
Zuhair M, Smit GSA, Wallis G et al (2019) Estimation of the worldwide seroprevalence of cytomegalovirus: A systematic review and meta-analysis. Rev Med Virol:e2034